Phosphodiesterase 4D gene and risk of noncardiogenic ischemic stroke in a korean population

Journal of Korean Medical Science

Volumn 24, Issue 2, 2009, Pages 307-310

  Kim, Myeong Kyu ^a   Kim, Jun Tae ^a   Choi, Sung Min ^a   Lee, Seung Han ^a   Park, Man Seok ^a   Cho, Ki Hyun ^a  

^a Chonnam National University   (South Korea)

Author keywords

Case control study; Genetics; Phosphodiesterases 4D; Stroke

Indexed keywords

PDE4D PROTEIN, HUMAN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV;

AGED; ARTICLE; ASIAN; BRAIN ISCHEMIA; CASE CONTROL STUDY; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; KOREA; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; REGRESSION ANALYSIS; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; KOREA; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; RISK; STROKE;

EID: 67650391458     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2009.24.2.307     Document Type: Article

References (19)

1. Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA 2006; 296: 2939-46.
2. Whisnant JP. Modeling of risk factors for ischemic stroke. The Willis Lecture. Stroke 1997; 28: 1840-4.
3. Alberts MJ. Genetics of cerebrovascular disease. Stroke 2004; 35: 342-4.
4. Dominiczak AF, McBride MW. Genetics of common polygenic stroke. Nat Genet 2003; 35: 116-7.
5. Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjornsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003; 35: 131-8.
6. Bevan S, Porteous L, Sitzer M, Markus HS. Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. Stroke 2005; 36: 949-53.
7. Lohmussaar E, Gschwendtner A, Mueller JC, Org T, Wichmann E, Hamann G, Meitinger T, Dichgans M. ALOX5AP gene and the PD-E4D gene in a central European population of stroke patients. Stroke 2005; 36: 731-6.
8. Meschia JF, Brott TG, Brown RD Jr, Crook R, Worrall BB, Kissela B, Brown WM, Rich SS, Case LD, Evans EW, Hague S, Singleton A, Hardy J. Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Ann Neurol 2005; 58: 351-61.
9. Nakayama T, Asai S, Sato N, Soma M. Genotype and haplotype association study of the STRK1 region on 5q12 among Japanese: a case-control study. Stroke 2006; 37: 69-76.
10. Nilsson-Ardnor S, Wiklund PG, Lindgren P, Nilsson AK, Janunger T, Escher SA, Hallbeck B, Stegmayr B, Asplund K, Holmberg D. Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population. Stroke 2005; 36: 1666-71.
11. Saleheen D, Bukhari S, Haider SR, Nazir A, Khanum S, Shafqat S, Anis MK, Frossard P. Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population. Stroke 2005; 36: 2275-7.
12. van Rijn MJ, Slooter AJ, Schut AF, Isaacs A, Aulchenko YS, Snijders PJ, Kappelle LJ, van Swieten JC, Oostra BA, van Duijn CM. Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population. Neurology 2005; 65: 1203-9.
13. Woo D, Kaushal R, Kissela B, Sekar P, Wolujewicz M, Pal P, Alwell K, Haverbusch M, Ewing I, Miller R, Kleindorfer D, Flaherty M, Chakraborty R, Deka R, Broderick J. Association of phosphodiesterase 4D with ischemic stroke: a population-based case-control study. Stroke 2006; 37: 371-6.
14. Goessens BM, Visseren FL, Kappelle LJ, Algra A, van der Graaf Y. Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease: the SMART study. Stroke 2007; 38: 1470-5.
15. Minn YK, Cho SJ, Lee JH, Kim SY, Kim CH, Kwon KH, Lee BC. Significance of silent infarcts in acute ischemic stroke patients aged 80 years and older. Cerebrovasc Dis 2005; 20: 92-5.
16. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.
17. Staton JM, Sayer MS, Hankey GJ, Attia J, Thakkinstian A, Yi Q, Cole VJ, Baker R, Eikelboom JW. Association between phosphodiesterase 4D gene and ischaemic stroke. J Neurol Neurosurg Psychiatry 2006; 77: 1067-9.
18. Cardiogenic brain embolism. The second report of the cerebral embolism task force. Arch Neurol 1989; 46: 727-43.
19. Gretarsdottir S, Sveinbjornsdottir S, Jonsson HH, Jakobsson F, Einarsdottir E, Agnarsson U, Shkolny D, Einarsson G, Gudjonsdottir HM, Valdimarsson EM, Einarsson OB, Thorgeirsson G, Hadzic R, Jonsdottir S, Reynisdottir ST, Bjarnadottir SM, Gudmundsdottir T, Gudlaugsdottir GJ, Gill R, Lindpaintner K, Sainz J, Hannesson HH, Sigurdsson GT, Frigge ML, Kong A, Gudnason V, Stefansson K, Gulcher JR. Localization of a susceptibility gene for common forms of stroke to 5q12. Am J Hum Genet 2002; 70: 593-603.