Hemorrhagic shock and reperfusion injury: The critical interplay of fibrin fragments, leukocytes, and vascular endothelial-cadherin

Critical Care Medicine

Volumn 37, Issue 2, 2009, Pages 771-772

  Beishuizen, Albertus ^a   Girbes, Armand R J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

15 42; B ; Fibrin related peptide; FX06; Hemorrhagic shock; Ischemia; Organ failure; Reperfusion

Indexed keywords

CALCIUM; FIBRIN DEGRADATION PRODUCT; FX 06; NITRIC OXIDE; OXYGEN RADICAL; POLYPEPTIDE; SUPEROXIDE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ABSENCE OF SIDE EFFECTS; BLOOD CLOTTING DISORDER; CELL DEATH; CELL INFILTRATION; COMPLEMENT ACTIVATION; EDITORIAL; ERYTHROCYTE TRANSFUSION; HEART INFARCTION; HEMORRHAGIC SHOCK; HUMAN; INTENSIVE CARE UNIT; ISCHEMIA; LENGTH OF STAY; LEUKOCYTE; LEUKOCYTE MIGRATION; MEMBRANE DAMAGE; MICROVASCULATURE; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; RESUSCITATION; TISSUE INJURY; VASODILATATION;

CADHERINS; CELL MOVEMENT; CLINICAL TRIALS AS TOPIC; ENDOTHELIUM, VASCULAR; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; LEUKOCYTES; MYOCARDIAL REPERFUSION; PEPTIDE FRAGMENTS; REPERFUSION INJURY; SHOCK, HEMORRHAGIC;

EID: 67650346164     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318194bd9e     Document Type: Editorial

References (17)

1. Liem DA, Honda HM, Zhang J, et al: Past and present course of cardioprotection against ischemia-reperfusion injury. J Appl Physiol 2007; 103:2129-2136
2. Carden DL, Granger DN: Pathophysiology of ischaemia-reperfusion injury. J Pathol 2000; 190:255-266
3. Grisham MB, Granger DN, Lefer DJ: Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: Relevance to ischemic heart disease. Free Radic Biol Med 1998; 25:404-433
4. Granger DN: Ischemia-reperfusion: Mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 1999; 6:167-178
5. Kurose I, Anderson DC, Miyasaka M, et al: Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage. Circ Res 1994; 74:336-343
6. Petzelbauer P, Zacharowski PA, Miyazaki Y, et al: The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med 2005; 11: 298-304
7. Roesner JP, Petzelbauer P, Koch A, et al: The fibrin-derived peptide Bbeta15-42 is cardio-protective in a pig model of myocardial isch-emia-reperfusion injury. Crit Care Med 2007; 35:1730-1735
8. Zacharowski K, Zacharowski P, Reingruber S, et al: Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocar-dial infarction. J Mol Med 2006; 84:469-477
9. Zacharowski K, Zacharowski PA, Friedl P, et al: The effects of the fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of myocardial ischemia-reperfusion. Shock 2007; 27:631-637
10. Atar D, Huber K, Rupprecht HJ, et al: Rationale and design of the 'F.I.R.E.' study. A multi-center, double-blind, randomized, placebo-controlled study to measure the effect of FX06 (a fibrin-derived peptide Bbeta(15-42)) on ischemia-reperfusion injury in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Cardiology 2007; 108:117-123
11. 15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reper-fusion. Crit Care Med 2009; 37:598-605
12. Kauvar DS, Lefering R, Wade CE: Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma 2006; 60:S3-S11
13. Malone DL, Dunne J, Tracy JK, et al: Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003; 54:898-905
14. Buerke U, Pruefer D, Carter JM, et al: Sodium/hydrogen exchange inhibition with cari-poride reduces leukocyte adhesion via P-selectin suppression during inflammation. Br J Pharmacol 2008; 153:1678-1685
15. Mathes AM, Kubulus D, Pradarutti S, et al: Melatonin pretreatment improves liver function and hepatic perfusion after hemorrhagic shock. Shock 2008; 29:112-118
16. Honma K, Koles NL, Alam HB, et al: Administration of recombinant interleukin-11 improves the hemodynamic functions and decreases third space fluid loss in a porcine model of hemorrhagic shock and resuscitation. Shock 2005; 23:539-542
17. Calvey CR, Toledo-Pereyra LH: Selectin inhibitors and their proposed role in ischemia and reperfusion. J Invest Surg 2007; 20: 71-85