Acute massive gastrointestinal bleeding in the elderly

Japanese Journal of Geriatrics

Volumn 46, Issue 3, 2009, Pages 250-258

  Kimura, Akihiro ^a   Iwamoto, Toshihiko ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Acute hemorrhagic gastroduodenal ulcer; Anti dementia drugs; Anti thrombotic agents; Endoscopic findings; Nsaids

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT;

ACUTE DISEASE; AGED; ARTICLE; CHEMICALLY INDUCED DISORDER; DEMENTIA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; MALE; POLYPHARMACY;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DEMENTIA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; POLYPHARMACY;

EID: 67650345357     PISSN: 03009173     EISSN: None     Source Type: Journal    
DOI: 10.3143/geriatrics.46.250     Document Type: Article

References (32)

1. Antithrombotic Trialist' Collaboration: Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324:71-86.
2. Rogers SL. Farlow MR, Doody RS, Mohs R, Friedhoff LT: A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease: donepezil study group. Neurology 1999; 50:136-145.
3. Triot PN, Cummings JL, Katz IR, Mintzer J, Perdomo CA, Schwam EM, et al.: Randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting. J Am Geriatr Soc 2001; 49: 1590 - 1599.
4. Gabriel SE, Jaakkimainen L, Bombardier C: Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann Inter Med 1991; 115:787-796.
5. Rodriguez LAG, Jick H: Risk of upper gastrointestinal bleeding and perforation associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994; 343:769- 772.
6. Yeomans ND, Lanas Al, Talley NJ. Thomson ABR, Daneshjoo R, Eriksson B, et al.: Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther 2005; 22:795-801.
7. Derry S, Loke YK: Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000; 321:1183-1187.
8. Japanese source
9. Japanese source
10. Wolfe MM, Lichtenstein DR, Singh G: Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. N Engl J Med 1999; 340:1888-1899.
11. Serrano P, Lanas A, Arroyo MT, Ferreira IJ: Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases. Aliment Pharmacol Ther 2002; 16:1945-1953.
12. Scheinman JM: Unmet needs in non-steroidal antiinflammatory drug-induced upper gastrointestinal diseases. Drugs 2006; 66, suppl. 1:15-21, discussion 29-33.
13. Pilotto A, Franceschi M, Leandro G, Di Mario F: Geriatric Gastroenterology Study Group (Societe Italiana Gerontologie Geriatria): NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies. Drugs Aging 2003; 20:701-710.
14. Ootani H, Iwakiri R, Shimoda R, Nakahara S, Amemori S, Fujise T, et al.: Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use in bleeding peptic ulcers in Japan. J Gastroenterol 2006; 41:41-46.
15. De Abajo FJ, Rodriguez LAG, Montero D: Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case- control study. BMJ 1999; 319:1106-1109.
16. Shorr RI, Ray WA, Daugherty JR, Griffin MR: Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993; 153:1665-1670.
17. Piper JM, Ray WA, Daugherty JR, Griffin MR: Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991; 114: 735-740.
18. Graham DY, Malaty HM: Alendronate and naproxen are synergistic for development of gastric ulcers. Arch Intern Med 2001; 161: 107-110.
19. Hallas J, Dall M, Andries A, Andersen BS, Aalykke C, Hansen JM, et al.: Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study. BMJ 2006; 333:726-728.
20. Van Soest EM: Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and hemorrhage. Aliment Pharmacol Ther 2007; 26:265-275.
21. Kelly JP, Kaufman DW, Jurgelon JM, Sheehan J, Koff RS, Shapiro S: Risk of aspirin-associated major upper gastrointestinal bleeding with enteric-coated or buffered product. Lancet 1996; 348:1413-1416.
22. Guslandi M, Pellegrini A, Sorghi M: Gastric mucosal defences in the elderly. Gerontology 1999; 45:206-208.
23. Griffin MR; Epidemiology of nonsteroidal antiinflammatory drug-associated gastrointestinal injury. Am J Med 1998; 104 (3A): 23S-29S; discussion 41S-42S.
24. Pilotto A, Franceschi M, Leandro G, Paris F, Niro V, Longo MG, et al.: The risk of upper gastrointestinal bleeding in elderly users of aspirin and other nonsteroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging Clin Exp Res 2003; 15:494-499.
25. Mamdani M, Rochon PA, Juurlink DN, Kopp A, Anderson GM, Naglie G, et al.: Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs. BMJ 2002; 325:624.
26. Lai KC, Lam SK, Chu KM, Wong BCY, Hui WM, Hu WHC, et al.: Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 2002; 346:2033-2038.
27. Japanese source
28. Hart RG, Sherman DG, Easton JD, Cairns JA: Prevention of stroke in patients with nonvalvular atrial fibrillation. Neurology 1998; 51:674-681.
29. Taggart H, Bologness MA, Lindsay R, Ettinger MP, Hulder H, Jose RG, et al.: Upper gastrointestinal tract safety of risedronate: a pooled analysis of 9 clinical trials. Mayo Clin Proc 2002; 77:262-270.
30. Messer J, Reitman D, Sacko HS, Smith H, Chalmers TC: Association of adrenocorticosteroid therapy and peptic ulcer disease. N Engl J Med 1983; 309:21-24.
31. Cholongitas E, Pipili C, Dasenaki M: Recurrence of upper gastrointestinal bleeding after donepezil administration. Alzheimer Disease & Associated Disorders 2006; 20:326.
32. Vernava AM 3rd, Moore BA, Longo WE, Johnson FE: Lower gastrointestinal bleeding. Dis Colon Rectum 1997; 40:846-858.