Short report: High prevalence and fixation of Plasmodium vivax dhfr/dhps mutations related to sulfadoxine/pyrimethamine resistance in French Guiana

American Journal of Tropical Medicine and Hygiene

Volumn 81, Issue 1, 2009, Pages 19-22

  Barnadas, Céline ^a   Musset, Lise ^b   Legrand, Eric ^b   Tichit, Magali ^c   Briolant, Sébastien ^d   Fusai, Thierry ^d   Rogier, Christophe ^d   Bouchier, Christiane ^c   Picot, Stéphane ^a   Ménard, Didier ^e  

^a UNIVERSITÉ LYON 1   (France)

^b INSTITUT PASTEUR DE LA GUYANE   (French Guiana)

^c INSTITUT PASTEUR   (France)

^d SERVICE DE SANTÉ DES ARMÉES   (France)

^e INSTITUT PASTEUR DE MADAGASCAR   (Madagascar)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR; ANTIMALARIAL AGENT; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; GENE FREQUENCY; GENE LOCUS; GENOTYPE; HAPLOTYPE; HUMAN; MALARIA; MUTANT; NONHUMAN; PLASMODIUM VIVAX; POINT MUTATION; ANIMAL; DRUG COMBINATION; DRUG EFFECT; DRUG RESISTANCE; GENETICS; MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM;

PLASMODIUM VIVAX;

ANIMALS; ANTIMALARIALS; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG RESISTANCE; MUTATION; PLASMODIUM VIVAX; POLYMORPHISM, SINGLE NUCLEOTIDE; PYRIMETHAMINE; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 67650337835     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2009.81.19     Document Type: Article

References (25)

1. Mendis K, Sina BJ, Marchesini P, Carter R, 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64: 97-106.
2. Hay SI, Guerra CA, Tatem AJ, Noor AM, Snow RW, 2004. The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis 4: 327-336.
3. Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM, 2007. Vivax malaria: neglected and not benign. Am J Trop Med Hyg 77: 79-87.
4. Duarte EC, Gyorkos TW, Pang L, Abrahamowicz M, 2004. Epidemiology of malaria in a hypoendemic Brazilian Amazon migrant population: a cohort study. Am J Trop Med Hyg 70: 229-237.
5. Legrand E, Volney B, Meynard JB, Mercereau-Puijalon O, Esterre P, 2008. In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005. Antimicrob Agents Chemother 52: 288-298.
6. Carme B, 2005. Substantial increase of malaria in inland areas of eastern French Guiana. Trop Med Int Health 10: 154-159.
7. Picot S, 2006. Is Plasmodium vivax still a paradigm for uncomplicated malaria? Med Mal Infect 36: 406-413.
8. D'Ortenzio E, Durand R, Pradines B, Parzy D, Lebras J, 2005. Dernières recommandations sur la prévention et le traitement du paludisme. Available at: http://www.phans.asso.fr/Documents%20partages/ Journees%20medicales/PALUDISMEpc.pdf. Accessed January 13, 2009.
9. Cortese JF, Caraballo A, Contreras CE, Plowe CV, 2002. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. J Infect Dis 186: 999-1006.
10. Alecrim WD, Dourado H, Alecrim MG, Passos LF, Wanssa E, Albuquerque B, 1982. In vivo resistance of Plasmodium falciparum to the combination of sulfadoxine and pyrimethamine, at RIII level, in Amazonas, Brazil. Rev Inst Med Trop Sao Paulo 24: 52-53.
11. Espinal CA, Cortes GT, Guerra P, Arias AE, 1985. Sensitivity of Plasmodium falciparum to antimalarial drugs in Colombia. Am J Trop Med Hyg 34: 675-680.
12. Roper MH, Torres RS, Goicochea CG, Andersen EM, Guarda JS, Calampa C, Hightower AW, Magill AJ, 2000. The epidemiology of malaria in an epidemic area of the Peruvian Amazon. Am J Trop Med Hyg 62: 247-256.
13. Prajapati SK, Joshi H, Valecha N, Reetha AM, Eapen A, Kumar A, Das MK, Yadav RS, Rizvi MA, Dash AP, 2007. Allelic polymorphism in the Plasmodium vivax dihydrofolate reductase gene among Indian field isolates. Clin Microbiol Infect 13: 331-334.
14. Alam MT, Bora H, Bharti PK, Saifi MA, Das MK, Dev V, Kumar A, Singh N, Dash AP, Das B, Wajihullah, Sharma YD, 2007. Similar trends of pyrimethamine resistance-associated mutations in Plasmodium vivax and P. falciparum. Antimicrob Agents Chemother 51: 857-863.
15. Hawkins VN, Joshi H, Rungsihirunrat K, Na-Bangchang K, Sibley CH, 2007. Antifolates can have a role in the treatment of Plasmodium vivax. Trends Parasitol 23: 213-222.
16. Legrand E, Volney B, Lavergne A, Tournegros C, Florent L, Accrombessi D, Guillotte M, Mercereau-Puijalon O, Esterre P, 2005. Molecular analysis of two local falciparum malaria outbreaks on the French Guiana coast confirms the msp1 B-K1/varD genotype association with severe malaria. Malar J 4: 26.
17. Snounou G, 1996. Detection and identification of the four malaria parasite species infecting humans by PCR amplification. Methods Mol Biol 50: 263-291.
18. Imwong M, Pukrittayakamee S, Renia L, Letourneur F, Charlieu JP, Leartsakulpanich U, Looareesuwan S, White NJ, Snounou G, 2003. Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob Agents Chemother 47: 1514-1521.
19. Korsinczky M, Fischer K, Chen N, Baker J, Rieckmann K, Cheng Q, 2004. Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site. Antimicrob Agents Chemother 48: 2214-2222.
20. Hall TA, 1999. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 41: 95-98.
21. Targett GAT, 1992. Malaria - drug-use and the immune-response. Parasitology 105: S61-S70.
22. Tjitra E, Baker J, Suprianto S, Cheng Q, Anstey NM, 2002. Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine- pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations. Antimicrob Agents Chemother 46: 3947-5393.
23. Hawkins VN, Auliff A, Prajapati SK, Rungsihirunrat K, Hapuarachchi HC, Maestre A, O'Neil MT, Cheng Q, Joshi H, Na-Bangchang K, Sibley CH, 2008. Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase. Malar J 7: 72.
24. McCollum AM, Mueller K, Villegas L, Udhayakumar V, Escalante AA, 2007. Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America. Antimicrob Agents Chemother 51: 2085-2091.
25. Khalil I, Ronn AM, Alifrangis M, Gabar HA, Satti GM, Bygbjerg IC, 2003. Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole. Am J Trop Med Hyg 68: 586-589.