Small molecule selectin inhibitor in global cerebral ischemia and controlled hemorrhagic shock

Journal of Trauma - Injury, Infection and Critical Care

Volumn 65, Issue 3, 2008, Pages 678-684

  Anaya Prado, Roberto ^a   Pérez Gomez, Nahum ^a   Toledo Pereyra, Luis H ^a,b,c   Walsh, John ^a   Jordan, Jackie ^d   Ward, Peter A ^d  

^a Borgess Research Institute   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cerebral Ischemia; Leukocytes; TBC 1269

Indexed keywords

BIMOSIAMOSE; BIPHENYL DERIVATIVE; CELL ADHESION MOLECULE; DRUG THERAPY; MANNOSIDE; MYELOPEROXIDASE; PEROXIDASE; SELECTIN; SODIUM CHLORIDE;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN TISSUE; CAROTID ARTERY OBSTRUCTION; CELL COUNT; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG THERAPY; ENZYMOLOGY; HEMORRHAGIC SHOCK; MALE; MEAN ARTERIAL PRESSURE; METABOLISM; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTECTION; RAT; RESUSCITATION; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; SURVIVAL; SURVIVAL RATE;

ANIMALS; ANTAGONISTS AND INHIBITORS; BIPHENYL COMPOUNDS; BRAIN ISCHEMIA; CELL ADHESION MOLECULES; DISEASE MODELS, ANIMAL; DRUG THERAPY; ENZYMOLOGY; MALE; MANNOSIDES; METABOLISM; NEUTROPHIL INFILTRATION; PATHOLOGY; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; THERAPEUTIC USE;

IM; MLCS; MLOWN; NLM;

EID: 67650301834     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181843f3a     Document Type: Article

References (67)

1. Wang JY, Zhou DH, Li J. Association of soluble intercellular adhesion molecule 1 with neurological deterioration of ischemic stroke: The Chongqing Stroke Study. Cerebrovasc Dis. 2006;21:67-73.
2. Nadar SK, Lip GY, Blann AD. Platelet morphology, soluble P selectin and platelet P-selectin in acute ischaemic stroke. The West Birmingham Stroke Project. Thromb Haemost. 2004;92:1342-1348.
3. Nadar SK, Lip GY, Lee KW, Blann AD. Circulating endothelial cells in acute ischaemic stroke. Thromb Haemost. 2005;94:707-712.
4. Cha JK, Jeong MH, Kim JW. Statin reduces the platelet P-selectin expression in atherosclerotic ischemic stroke. J Thromb Thrombolysis. 2004;18:39-42.
5. Yip HK, Chen SS, Liu JS, Chang HW, et al. Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation. Stroke. 2004;35:1683-1687.
6. Zeller JA, Lenz A, Eschenfelder CC, Zunker P, Deuschl G. Platelet-leukocyte interaction and platelet activation in acute stroke with and without preceding infection. Arterioscler Thromb Vasc Biol. 2005; 25:1519-1523.
7. Bronner LL, Kanter DS, Manson JE. Primary prevention of stroke. N Engl J Med. 1995;333:1392-1400.
8. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study. JAMA. 1995;274:1017-1025.
9. Fassbender K, Mössner R, Motsch L, Kischka U, Grau A, Hennerici M. Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke. Stroke. 1995;26:1361-1364.
10. Ishikawa M, Vowinkel T, Stokes KY, et al. CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/ reperfusion. Circulation. 2005;111:1690-1696.
11. Ishikawa M, Cooper D, Russell J, et al. Molecular determinants of the prothrombogenic and inflammatory phenotype assumed by the postischemic cerebral microcirculation. Stroke. 2003;34:1777-1782.
12. Ulh E, Beck J, Stummer W, Lehmberg J, Baethmann A. Leukocyte-endothelium interactions in pial venules during the early and late reperfusion period after global cerebral ischemia in gerbils. J Cereb Blood Flow Metab. 2000;20:979-987.
13. Ritter LS, Orozco JA, Coull BM, McDonagh PF, Rosenblum WI. Leukocyte accumulation and hemodynamic changes in the cerebral microcirculation during early reperfusion after stroke. Stroke. 2000; 31:1153-1161.
14. Ishikawa M, Stokes KW, Zhang JH, Nanda A, Granger DN. Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin. Circ Res. 2004;94:239-244.
15. Cassie S, Masterson MF, Polukoshko A, Viskovic MM, Tibbles LA. Ischemia/reperfusion induces the recruitment of leukocytes from whole blood under flow conditions. Free Radic Biol Med. 2004; 36:1102-1111.
16. Ishikawa M, Cooper D, Arumugam TV, Zhang JH, Nanda A, Granger DN. Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion. J Cereb Blood Flow Metab. 2004;24:907-915.
17. Xu XM, Zhang Y, Zeng FD. Effects of sodium beta-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats. Acta Pharmacol Sin. 2004; 25:869-875.
18. Samson Y, Lapergue B, Hosseini H. Inflammation and ischaemic stroke: current status and future perspectives. Rev Neurol (Paris). 2005;161(12 Pt 1):1177-1182.
19. Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev. 2002;39:55-73.
20. Lehmberg J, Beck J, Baethmann A, Uhl E. Effect of P-selectin inhibition on leukocyte-endothelium interaction and survival after global cerebral ischemia. J Neurol. 2006;253:357-363.
21. Ruehl ML, Orozco JA, Stoker MB, McDonagh PF, Coull BM, Ritter LS. Protective effects of inhibiting both blood and vascular selectins after stroke and reperfusion. Neurol Res. 2002;24:226-232.
22. Carden DL, Granger DN. Pathophysiology of ischemia-reperfusion injury. J Pathol. 2000;190:255-266.
23. Harlan JM, Winn RK. Leukocyte-endothelial interactions: clinical trials of anti-adhesive therapy. Crit Care Med. 2002;30:S214-S219.
24. Frijns CJ, Kappelle LJ. Inflammatory cell adhesion molecules in ischemic cerebrovascular disease. Stroke. 2002;33:2115-2122.
25. del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke. 1991;22:1276-1283.
26. Jean WC, Spellman SR, Nussbaum ES, Low WC. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery. 1998;43:1382-1396.
27. Matsuo Y, Onodera H, Shiga Y, Nakamura M, Ninomiya M, Kihara T. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Stroke. 1994;25:1469-1475.
28. Kochanek PM, Hallenbeck JM. Polymorphonuclear leuokocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke. 1992;23:1367-1379.
29. Mori E, del Zoppo GJ, Chambers JD, Copeland BR, Arfors KE. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke. 1992; 23:712-718.
30. Dutka AJ, Kochaneck PM, Hallenbeck JM. Influence of granulocytepenia on canine cerebral ischemia induced by air embolism. Stroke. 1989;20:390-395.
31. Hallenbeck JM, Dutka AJ, Tanishima T, et al. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke. 1986;17:246-253.
32. Prentice RL, Szatrowski TP, Kato H, Mason MW. Leukocyte counts and cerebrovascular disease. J Chron Dis. 1982;35:703-714.
33. Bednar MM, Gross CE, Balazy M, Falck JR. Antineutrophil strategies. Neurology. 1997;49:S20-S22.
34. Pozzilli C, Lenzi GL, Argentino C, Carolei A, Rasura M, Signore A. Imaging of leukocytic infiltration in human cerebral infarcts. Stroke. 1985;16:251-255.
35. Emerich DF, Dean RL III, Bartus RT. The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct? Exp Neurol. 2002;173:168-181.
36. Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab. 1999;19:819-834.
37. Clark WM, Lutsep HL. Potential of anticytokine therapies in central nervous system ischaemia. Expert Opin Biol Ther. 2001;1:227-237.
38. Kuroda S, Siesjo BK. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci. 1997; 4:199-212.
39. Zhang RL, Chopp M, Chen H, Garcia JH. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci. 1994;125:3-10.
40. van Lookeren Campagne M, Thomas GR, Thibodeaux H, Palmer JT, Williams SP, Lowe DG. Secondary reduction in the apparent diffusion coefficient of water, increase in cerebral blood volume, and delayed neuronal death after middle cerebral artery occlusion and early reperfusion in the rat. J Cereb Blood Flow Metab. 1999; 19:1354-1364.
41. Zhang RL, Zhang ZG, Chopp M, Zivin JA. Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke. 1999;30:624-629.
42. Zhang RL, Zhang ZG, Chopp M. Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat. Neurology. 1999;52:273-279.
43. Rothlein R. Overview of leukocyte adhesion. Neurology. 1997;49:S3-S4.
44. Joyle C, Milinkevitch S, Favreau F, et al. Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury. Kidney Int. 2006;69:1749-1755.
45. Michail S, Mezoff E, Abernathy F. The role of selectins in the intestinal epithelial migration of eosinophils. Pediatr Res. 2005;58:644 - 647.
46. Davenpeck KL, Barens KL, Dixon RA, Dupre B, Bochner BS. Inhibition of adhesion of human neutrophils and eosinophils to P-selectin by the sialyl Lewis antagonist TBC-1269: preferential activity against neutrophil adhesion in vitro. J Allergy Clin Immunol. 2000; 105:769-775.
47. Ramos-Kelly JR, Toledo-Pereyra LH, Jordan J, et al. Multiple selectin blockade with a small molecule inhibitor downregulates liver chemokine expression and neutrophil infiltration after hemorrhagic shock. J Trauma. 2000;49:92-100.
48. Beauharnois ME, Lindquist KC, Marathe D, et al. Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L- and P-selectin. Biochemistry. 2005;44:9507-9519.
49. Toledo-Pereyra LH, Lopez-Neblina F, Reuben JS, Toledo AH, Ward PA. Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion. J Invest Surg. 2004;17:303-313.
50. Onai Y, Suzuki J, Nishiwaki Y, et al. Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury. Eur J Pharmacol. 2003;481:217-225.
51. Härtl R, Schürer L, Schmid-Schönebin GW, del Zoppo GJ. Experimental antiluekocytes interventions in cerebral ischemia. J Cereb Blood Flow Metab. 1996;16:1108-1119.
52. Zhang RL, Chopp M, Li Y, Zaloga C, Jiang N, Jones ML Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat. Neurology. 1994;44:1747-1751.
53. Goussev AV, Zhang Z, Anderson DC, Chopp M. P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat. J Neurol Sci. 1998;161:16 -22.
54. Beray-Berthat V, Croci N, Plotkine M, Margaill I. Polymorphonuclear neutrophils contribute to infarction and oxidative stress in the cortex but not in the striatum after ischemia-reperfusion in rats. Brain Res. 2003; 987:32-38.
55. Santizo RA, Anderson S, Shuhua Y, Koenig HM, Pelligrino DA. Effects of estrogen on leukocyte adhesion after transient forebrain ischemia. Stroke. 2000;31:2231-2235.
56. Clark WM, Lauten JD, Lessov N, Woodward W, Coull BM. Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol Chem Neuropath. 1995;26:213-230.
57. Chen H, Chopp M, Zhang RL, Bodzing G, Chen Q, Rusche JR. Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat. Ann Neurol. 1994; 35:458-463.
58. Chopp M, Zhang RL, Jiang N. The role of adhesion molecules in reducing cerebral ischemic. Adv Neurol. 1996;71:315-326.
59. Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke. 1995;26:1438-1442.
60. Aspey BS, Jessimer C, Pereira S, Harrison MJG. Do leukocytes have a role in the cerebral no-reflow phenomenon? J Neurol Neurosug Psychiatry. 1989;52:526-528.
61. Yong Y, Xie HJ, Zhang YF, et al. 17beta-estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats. Brain Res. 2005;1054:192-199.
62. Clark WM, Zivin JA. Antileukocyte adhesion therapy: preclinical trails and combination therapy. Neurology. 1997;49:S32-S38.
63. Strachan RD, Kane PJ, Cook S, Chambers IR, Clayton CB, Mendelow AD. Immunosupression by whole-body irradiation and its effect on oedema in nexperimental cerebral ischaemia. Acta Neurol Scand. 1992;86:256-259.
64. Takeshima R, Kirsch JR, Koehler RC, Gomoll AW, Traystam RJ. Monoclonal leukocyte antibody does not decrease the injury of transient focal cerebral ischemia in cats. Stroke. 1992;23:247-252.
65. Antonawich FJ, Fiore SM, Welicky LM. Regulation of ischemic cell death by lipoic acid-palladium complex, poly MVA, in gerbils. Exp Neurol. 2004;189:10-15.
66. Back T, Schuler OG. The natural course of lesion development in brain ischemia. Acta Neurochir. 2004;89:S55-S61.
67. Turley KR, Toledo-Pereyra LH, Kothari RU. Molecular mechanisms in the pathogenesis and treatment of acute ischemic stroke. J Invest Surg. 2005;18:207-218.