Effect of P-selectin inhibition on leukocyte-endothelium interaction and survival after global cerebral ischemia

Journal of Neurology

Volumn 253, Issue 3, 2006, Pages 357-363

  Lehmberg, Jens ^a,c   Beck, Jürgen ^b,c   Baethmann, Alexander ^c   Uhl, Eberhard ^c,d  

^a Department of Neurosurgery ^*  (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Global ischemia; Leukocyte; Microcirculation; P selectin

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; P SELECTIN ANTIBODY; PADGEM PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM; EPIFLUORESCENCE MICROSCOPY; GERBIL; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; LEUKOCYTE ADHERENCE; MALE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; SURVIVAL;

ANIMALS; ANTIBODIES; BLOOD PRESSURE; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ENDOTHELIUM; GERBILLINAE; LEUKOCYTES; MALE; P-SELECTIN; TIME FACTORS;

EID: 33644945725     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-005-0996-4     Document Type: Article

References (38)

1. Longstreth-WT J, Diehr P, Inui TS (1983) Prediction of awakening after out-of-hospital cardiac arrest. N Engl J Med 308:1378-1382
2. Ito U, Spatz M, Walker-JTJ, Klatzo I (1975) Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations. Acta Neuropathol (Berl) 32:209-223
3. Kowada M, Ames A, Majno G, Wright RL (1968) Cerebral ischemia. I. An improved experimental method for study; cardiovascular effects and demonstration of an early vascular lesion in the rabbit. J Neurosurg 28:150-157
4. Hossmann KA, Lechtape-Gruter H, Hossmann V (1973) The role of cerebral blood flow for the recovery of the brain after prolonged ischemia. Z Neurol 204:281-299
5. Hossmann KA (1993) Ischemia-mediated neuronal injury. Resuscitation 26:225-235
6. Uhl E, Beck J, Stummer W, Lehmberg J, Baethmann A (2000) Leukocyte-endothelium interactions in pial venules during the early and late reperfusion period after global cerebral ischemia in gerbils. J Cereb Blood Flow Metab 20:979-987
7. Vestweber D, Blanks JE (1999) Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 79:181-213
8. Welbourn CR, Goldman G, Paterson IS, Valeri CR, Shepro D, Hechtman HB (1991) Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil. Br J Surg 78:651-655
9. Walder CE, Green SP, Darbonne WC, Mathias J, Rae J, Dinauer MC, Curnutte JT, Thomas GR (1997) Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke 28:2252-2258
10. Matsuo Y, Onodera H, Shiga Y, Shozuhara H, Ninomiya M, Kihara T, Tamatani T, Miyasaka M, Kogure K (1994) Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat. Brain Res 656:344-352
11. Chen H, Chopp M, Zhang RL, Bodzin G, Chen Q, Rusche JR, Todd RF (1994) Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat. Ann Neurol 35:458-463
12. Emerich DF, Dean RL III, Bartus RT (2002) The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct? Exp Neurol 173:168-181
13. Schürer L, Grögaard B, Gerdin B, Kempski O, Arfors K-E (1991) Leucocyte depletion does not affect post-ischemic nerve cell damage in the rat. Acta Neurochir (Wien) 111:54-60
14. Heinel LA, Rubin S, Rosenwasser RH, Vasthare US, Tuma RF (1994) Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion. Brain Res Bull 34:137-141
15. Hartl R, Schurer L, Schmid SG, del Zoppo GJ (1996) Experimental antileukocyte interventions in cerebral ischemia. J Cereb Blood Flow Metab 16:1108-1119
16. Nolte D, Schmid P, Jager U, Botzlar A, Roesken F, Hecht R, Uhl E, Messmer K, Vestweber D (1994) Leukocyte rolling in venules of striated muscle and skin is mediated by P-selectin, not by L-selectin. Am J Physiol 267:H1637-H1642
17. Kunkel EJ, Jung U, Ley K (1997) TNF-alpha induces selectin-mediated leukocyte rolling in mouse cremaster muscle arterioles. Am J Physiol 272:H1391-H1400
18. Jones SP, Girod WG, Granger DN, Palazzo AJ, Lefer DJ (1999) Reperfusion injury is not affected by blockade of P-selectin in the diabetic mouse heart. Am J Physiol 277:H763-H769
19. Ohnishi M, Imanishi N (2000) Role of P-selectin in the migration of neutrophils to chemoattractant-induced cutaneous inflammation in mice. Inflammation 24:583-593
20. Rovainen CM, Woolsey TA, Blocher NC, Wang DB, Robinson OF (1993) Blood flow in single surface arterioles and venules on the mouse somatosensory cortex measured with videomicroscopy, fluorescent dextrans, non-occluding fluorescent beads, and computerassisted image analysis. J Cereb Blood Flow Metab 13:359-371
21. Stummer W, Weber K, Tranmer B, Baethmann A, Kempski O (1994) Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke 25:1862-1869
22. Suzuki H, Abe K, Tojo S, Morooka S, Kimura K, Mizugaki M, Itoyama Y (1997) Expressions of P-selectin- and HSP72-like immunoreactivities in rat brain after transient middle cerebral artery occlusion. Brain Res 759:321-329
23. Suzuki H, Abe K, Tojo S, Morooka S, Kimura K, Mizugaki M, Itoyama Y (1997) Postischemic expression of P-selectin immunoreactivity in rat brain. Neurosci Lett 228:151-154
24. Zhang R, Chopp M, Zhang Z, Jiang N, Powers C (1998) The expression of P- and E-selectins in three models of middle cerebral artery occlusion. Brain Res 785:207-214
25. Okada Y, Copeland BR, Mori E, Tung MM, Thomas WS, del Zoppo GJ (1994) P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 25:202-211
26. Geng JG, Bevilacqua MP, Moore KL, McIntyre TM, Prescott SM, Kim JM, Bliss GA, Zimmerman GA, McEver RP (1990) Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature 343:757-760
27. Goussev AV, Zhang Z, Anderson DC, Chopp M (1998) P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat. J Neurol Sci 161:16-22
28. Suzuki H, Hayashi T, Tojo SJ, Kitagawa H, Kimura K, Mizugaki M, Itoyama Y, Abe K (1999) Anti-P-selectin antibody attenuates rat brain ischemic injury. Neurosci Lett 265:163-166
29. Connolly-ES J, Winfree CJ, Prestigiacomo CJ, Kim SC, Choudhri TF, Hoh BL, Naka Y, Solomon RA, Pinsky DJ (1997) Exacerbation of cerebral injury in mice that express the P-selectin gene: identification of P-selectin blockade as a new target for the treatment of stroke. Circ Res 81:304-310
30. Haring HP, Berg EL, Tsurushita N, Tagaya M, del Zoppo GJ (1996) E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia. Stroke 27:1386-1391
31. Wang X, Yue TL, Barone FC, Feuerstein GZ (1995) Demonstration of increased endothelial leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex. Stroke 26:1665-1668
32. Kubes P, Jutila M, Payne D (1995) Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 95:2510-2519
33. Theilen H, Schrock H, Kuschinsky W (1993) Capillary perfusion during incomplete forebrain ischemia and reperfusion in rat brain. Am J Physiol 265:H642-H648
34. Grogaard B, Schurer L, Gerdin B, Arfors KE (1989) Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes. J Cereb Blood Flow Metab 9:500-505
35. Vasthare US, Heinel LA, Rosenwasser RH, Tuma RF (1990) Leukocyte involvement in cerebral ischemia and reperfusion injury. Surg Neurol 33:261-265
36. Schott RJ, Natale JE, Ressler SW, Burney RE, D'Alecy LG (1989) Neutrophil depletion fails to improve neurologic outcome after cardiac arrest in dogs. Ann Emerg Med 18:517-522
37. Furuya K, Takeda H, Azhar S, McCarron RM, Chen Y, Ruetzler CA, Wolcott KM, DeGraba TJ, Rothlein R, Hugli TE, del Zoppo GJ, Hallenbeck JM (2001) Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study. Stroke 32:2665-2674
38. Weber K, Baethmann A, Kempski O (1988) Determinants of survival after forebrain ischemia in Mongolian gerbils. Metab Brain Dis 3:247-255