Fecal calprotectin complements routine laboratory investigations in diagnosing childhood inflammatory bowel disease

Inflammatory Bowel Diseases

Volumn 15, Issue 5, 2009, Pages 756-759

  Quail, Michael A ^a   Russell, Richard K ^b   Van Limbergen, Johan E ^c   Rogers, Pam ^a   Drummond, Hazel E ^c   Wilson, David C ^d   Gillett, Peter M ^a  

^a ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^b ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Child; Crohn's disease; Fecal calprotectin; Inflammatory bowel disease diagnosis; Ulcerative colitis

Indexed keywords

C REACTIVE PROTEIN; CALGRANULIN; HEMOGLOBIN;

ARTICLE; BLOOD ANALYSIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ERYTHROCYTE DISORDER; ERYTHROCYTE SEDIMENTATION RATE; FECES ANALYSIS; FECES LEVEL; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBINOPATHY; HUMAN; HYPOALBUMINEMIA; MALE; PRIORITY JOURNAL; PROTEIN DEFECT; THROMBOCYTOPENIA; ULCERATIVE COLITIS;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; FECES; FEMALE; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; PROGNOSIS;

EID: 67650289790     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20820     Document Type: Article

References (20)

1. Gaya DR, Russell RK, Nimmo ER, et al. New genes in inflammatory bowel disease: lessons for complex diseases? Lancet. 2006;367:1271-1284.
2. Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(suppl A):5-6.
3. Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749-753.
4. Russell RK, Read JR, Rogers P, et al. Factors affecting the time to IBD diagnosis in children: Implications for practice. Gut. 2005; 54:359.
5. Beattie RM, Walker-Smith JA, Murch SH. Indications for investigation of chronic gastrointestinal symptoms. Arch Dis Child. 1995; 73:354-355.
6. Cabrera-Abreu JC, Davies P, Matek Z, et al. Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic. Arch Dis Child. 2005;89:69-71.
7. Mack DR, Langton C, Markowtiz J, et al. Laboratory values for children with newly diagnosed inflammatory bowel disease. Pediatrics. 2007; 119:1113-1119.
8. Bunn SK, Bisset WM, Main MJC, et al. Fecal calprotectin: Validation as a noninvasive measure of bowel inflammation in childhood inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2001;33:14-22.
9. Fagerberg UL, Lööf L, Merzoug RD, et al. Fecal calprotectin levels in healthy children studied with an improved assay. J Pediatr Gastroenterol Nutr. 2003;37:468-472.
10. Konikoff MR, Denson LA. Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease. Inflamm Bowel Dis. 2006;12:524-534.
11. Campeotto F, Butel MJ, Kalach N, et al. High fecal calprotectin concentrations in newborn infants. Arch Dis Child Fetal Neonatal Ed. 2004;89:F353-F355.
12. Bremner A, Roked S, Robinson R, et al. Faecal calprotectin in children with chronic gastrointestinal symptoms. Acta Paediatr. 2005;1855-1859.
13. Canani RB, Tanturri de Horatio L, Terrin G, et al. Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2006;42:9-15.
14. Carroccio A, Iacono G, Cottone M, et al. Diagnostic accuracy of fecal calprotectin assay in distinguishing organic causes of chronic diarrhea from irrtable bowel syndrome: a prospective study in adults and children. Clin Chem. 2003;49:861-867.
15. Fagerberg UL, Lööf L, Myrdal U, et al. Colorectal inflammation is well predicted by fecal calprotecin in children with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 2005;40:450-455.
16. Nissen AC, van Gils CE, Menheere PP, et al. Fecal calprotectin in healthy term and preterm infants. J Pediatr Gastroenterol Nutr. 2004; 38:107-108.
17. Olafsdottir E, Aksnes L, Fluge G, et al. Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and health children. Acta Paediatr. 2002;91:45-50.
18. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol. 1989;24(suppl 170):2-6.
19. Roseth AG, Schmidt PN, Fagerhol MK. Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease. Scand J Gastroenterol. 1999;34:50-54.
20. Van Limbergen J, Russell RK, Drummond HE, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology. 2008;135:1114-1122