15-deoxy-Δ-Prostaglandin J 2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H 292)

International Archives of Allergy and Immunology

Volumn 149, Issue SUPPL. 1, 2009, Pages 77-82

  Chiba, Takahito ^a   Ueki, Shigeharu ^b   Ito, Wataru ^b   Kato, Hikari ^b   Takeda, Masahide ^b   Kayaba, Hiroyuki ^b   Furue, Masutaka ^a   Chihara, Junichi ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b AKITA UNIVERSITY   (Japan)

Author keywords

15d PGJ 2; Airway epithelial cells; CRTH2; Cytokine; PGD 2

Indexed keywords

13,14 DIHYDRO 15 OXOPROSTAGLANDIN D2; 15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; CELL SURFACE RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN; PROSTAGLANDIN D2; RAMATROBAN; TROGLITAZONE; UNCLASSIFIED DRUG;

CELL CULTURE; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME KINETICS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-8; PROSTAGLANDIN D2; RESPIRATORY MUCOSA;

EID: 67650264649     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000211377     Document Type: Conference Paper

References (24)

1. 2 in normal and asthmatic men. N Engl J Med 1984;311:209-213.
2. 2 receptor CRTH2 with circulating T-helper-2 cells in patients with atopic dermatitis. J Invest Dermatol 2002;119:609-616.
3. 2 metabolite generated during inflammatory processes. J Biol Chem 2002;277:10459-10466.
4. 2 receptor, CRTH2. Br J Pharmacol 2002;137:1163-1172.
5. 2 receptors CRTH2 and DP. J Allergy Clin Immunol 2001;108:982-988.
6. 2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. J Biol Chem 2004;279:7663-7670.
7. 2 receptor DP2/CRTH2 increases allergic inflammation in mouse. J Immunol 2005;174:3703-3708.
8. Ueki S, Adachi T, Bourdeaux J, Oyamada H, Yamada Y, Chihara J, et al: Expression of PPARγ in eosinophils and its functional role in survival and chemotaxis. Immunol Lett 2003;86:183-189.
9. Matsuwaki Y, Ueki S, Adachi T, Oyamada H, Kamada Y, Chihara J, et al: The synthetic PPARγagonist troglitazone inhibits IL-5-induced CD69 upregulation and eosinophilderived neurotoxin release from eosinophils. Pharmacology 2005;74:169-173.
10. Ueki S, Matsuwaki Y, Kayaba H, Oyamada H, Kanda A, Chihara J, et al: Peroxisome proliferator-activated receptor γ regulates eosinophil functions: a new therapeutic target for allergic airway inflammation. Int Arch Allergy Immunol 2004;134(suppl 1): 30-36.
11. Honda K, Arima M, Cheng G, Taki S, Hirata H, Fukuda T, et al: Prostaglandin D 2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. J Exp Med 2003;198:533-543.
12. 2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTH2-independent pathway. Int Arch Allergy Immunol 2006;141:300-307.
13. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Vidal H, et al: Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptorαin humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997;46:1319-1327.
14. Khair OA, Devalia JL, Abdelaziz MM, Saps-ford RJ, Tarraf H, Davies RJ: Effect of Haemophilus influenzae endotoxin on the synthesis of IL-6, IL-8, TNFαand expression of ICAM-1 in cultured human bronchial epithelial cells. Eur Respir J 1994;7:2109-2116.
15. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J Biol Chem 1995;270:12953-12956.
16. Murray JJ, Tonnel AB, Brash AR, Roberts LJ 2nd, Gosset P, Oates JA, et al: Release of prostaglandin D 2 into human airways during acute antigen challenge. N Engl J Med 1986;315:800-804.
17. 2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. J Immunol 2002;168:1372-1379.
18. 2 induces synthesis of interleukin-8 by endothelial cells in a PPARγ-independent manner. Prostaglandins Other Lipid Mediat 2001;66:165-177.
19. Collins PD, Weg VB, Faccioli LH, Watson ML, Moqbel R, Williams TJ: Eosinophil accumulation induced by human interleukin-8 in the guinea-pig in vivo. Immunology 1993;79:312-318.
20. Gleich GJ, Adolphson CR, Kita H: The eosinophil and asthma;in Busse WW, Holgate ST (eds): Asthma and Rhinitis, ed 2. Oxford, Blackwell Science, 2000, pp 429-479.
21. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH: Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993;147:1557-1561.
22. Kikuchi I, Kikuchi S, Kobayashi T, Hagiwara K, Sakamoto Y, Nagata M, et al: Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils. Am J Respir Cell Mol Biol 2006;34:760-765.
23. 2 ) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Pflügers Arch 2006;453:177-187.
24. 2 binds to and activates H-Ras. Proc Natl Acad Sci USA 2003;100:4772-4777.