A simple method for assessing analgesic requirements and efficacy in rodents

Lab Animal

Volumn 38, Issue 7, 2009, Pages 246-247

  Wheat, Nathan J ^a   Cooper, Dale M ^b  

^a Department of Genetic and Molecular Toxicology   (United States)

^b Harlan   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT;

ANALGESIA; ANIMAL; ANIMAL DISEASE; ARTICLE; BODY WEIGHT; DRINKING; DRUG EFFECT; EATING; LABORATORY; METHODOLOGY; MOUSE; PAIN; PAIN ASSESSMENT; RAT; VETERINARY MEDICINE;

ANALGESIA; ANALGESICS; ANIMALS; BODY WEIGHT; DRINKING; EATING; LABORATORY ANIMAL SCIENCE; MICE; PAIN; PAIN MEASUREMENT; RATS; SURGERY, VETERINARY;

RODENTIA;

EID: 67650129842     PISSN: 00937355     EISSN: 15484475     Source Type: Journal    
DOI: 10.1038/laban0709-246     Document Type: Article

References (18)

1. Liles, J.H. & Flecknell, P.A. The effects of surgical stimulus on the rat and the influence of analgesic treatment. Br. Vet. J. 149, 515-525 (1993).
2. Liles, J.H. & Flecknell, P.A. The influence of buprenorphine or bupivicaine on the post-operative effects of laparotomy and bile-duct ligation in rats. Lab. Anim. 27, 374-380 (1993).
3. Flecknell, P.A., Orr, H.E., Roughan, J.V. & Stewart, R. Comparison of the effects of oral or subcutaneous carprofen or ketoprofen in rats undergoing laparotomy. Vet. Rec. 144, 65-67 (1999).
4. Jablonski, P., Howden, B.O. & Baxter, K. Influence of buprenorphine analgesia on post-operative recovery in two strains of rats. Lab. Anim. 35, 213-222 (2000).
5. Lawson, D.M., Duke, J.L., Zammit, T.G., Collins, H.L. & Dicarlo, S.E. Recovery from carotid artery catheterization performed under various anesthetics in male, Sprague-Dawley rats. Contemp. Top. Lab. Anim. Sci. 40, 18-22 (2001).
6. Roughan, J.V. & Flecknell, P.A. Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals. Lab. Anim. 36, 322-343 (2002).
7. Sharp, J., Zammit, T., Azar, T. & Lawson, D. Recovery of male rats from major abdominal surgery after treatment with various analgesics. Contemp. Top. Lab. Anim. Sci. 42, 22-27 (2003).
8. Cooper, D.M., Hoffman, W., Wheat, N. & Lee, H. Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic. Comp. Med. 55, 344-353 (2005).
9. Cooper, D.M., Hoffman, W., Wheat, N. & Lee, H. Duration of clinical effects and absence of referred hyperalgesia after femoral vein cannulation in rats. Comp. Med. 55, 440-444 (2005).
10. Cooper, D.M., Hoffman, W., Tomlinson, K. & Lee, H. Refinement of the dosage and dosing schedule of ketoprofen for postoperative analgesia in Sprague-Dawley rats. Lab Anim. (NY) 37, 271-275 (2008).
11. Brennan, M.P., Sinusas, A.J., Horvath, T.L., Collins, J.G. & Harding, M.J. Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine. Lab Anim. (NY) 38, 87-93 (2009).
12. National Research Council, Institute for Laboratory Animal Research. Recognition and Alleviation of Pain and Distress in Laboratory Animals 32-52 (National Academies Press, Washington, DC, 1992).
13. Brennan, T.J. Postoperative models of nociception. ILAR J. 40, 129-136 (1999).
14. Ness, T.J. Models of visceral nociception. ILAR J. 40, 119-128 (1999).
15. Ren, K. & Dubner, R. Inflammatory models of pain and hyperalgesia. ILAR J. 40, 111-118 (1999).
16. Hayes, K.E., Raucci, J.A., Gades, N.M. & Toth, L.A. An evaluation of analgesic regimens for abdominal surgery in mice. Contemp. Top. Lab. Anim. Sci. 39, 18-23 (2000).
17. Roughan, J.V. & Flecknell, P.A. Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats. Behav. Pharmacol. 15, 461-472 (2004).
18. Flecknell, P.A. The relief of pain in laboratory animals. Lab. Anim. 18, 147-160 (1984).