Inhibitor of cysteine peptidase does not influence the development of Leishmania mexicana in Lutzomyia longipalpis

Journal of Medical Entomology

Volumn 46, Issue 3, 2009, Pages 605-609

  Jecna, Lucie ^a   Svarovska, Anna ^a   Besteiro, Sebastien ^b   Mottram, Jeremy C ^b   Coombs, Graham H ^c   Volf, Petr ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; INSECT PROTEIN; PROTOZOAL PROTEIN;

ANIMAL; ARTICLE; ENZYMOLOGY; FEMALE; GENETICS; HOST PARASITE INTERACTION; LEISHMANIA MEXICANA; PARASITOLOGY; PATHOGENICITY; PHYSIOLOGY; PSYCHODIDAE;

ANIMALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; FEMALE; HOST-PARASITE INTERACTIONS; INSECT PROTEINS; LEISHMANIA MEXICANA; PROTOZOAN PROTEINS; PSYCHODIDAE;

HEXAPODA; LEISHMANIA MEXICANA; LUTZOMYIA LONGIPALPIS; PHLEBOTOMINAE; PROTOZOA; PSYCHODIDAE;

EID: 67650119689     PISSN: 00222585     EISSN: None     Source Type: Journal    
DOI: 10.1603/033.046.0327     Document Type: Article

References (26)

1. Benkova, I., and P. Volf. 2007. Effect of temperature on metabolism of Phlebotomus papatasi (Diptera: Psychod- idae). J. Med. Entomol. 44: 150-154.
2. Besteiro, S., G. H. Coombs, and J. C. Mottram. 2004. A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite. Mol. Microbiol. 54: 1224-1236.
3. Borovski, D., and Y. Schlein. 1987. Trypsin and chemotryp- sin enzymes of the sandfly Phlebotomus papatasi infected with Leishmania and their possible role in vector competence. Med. Vet. Entomol. 1: 235-242.
4. Dillon, R. J., and R. P. Lane. 1993a. Bloodmeal digestion in the midgut of Phlebotomus papatasi and Phlebotomus langeroni. Med. Vet. Entomol. 7: 225-232.
5. Dillon, R. J., and R. P. Lane. 1993b. Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni. Parasitol. Res. 79: 492- 496.
6. Dos Santos Monteiro, A. C, O. B. de Oliveira Neto, R. P. Del Sarto, M. T. de Magalhaes, J. N. Lima, A. F. Lacerda, R. S. Oliveira, J. Scharfstein, M. C. da Silva, J. W. Valencia, A. V. Jimenez, and M. F. Grossi-de-Sa. 2008. A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases. Pest. Manag. Sci. 64: 755-760.
7. Jochim, R. C, C. R Teixeira, A. Laughinghouse, J. Mu, F. Oliveira, R. B. Gomes, D. E. Elnaiem, and J. G. Valen- zuela. 2008. The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies. BMC Genomics 14: 9-15.
8. Kamhawi, S. 2006. Phlebotomine sand flies and Leishmania parasites: friends or foes? Trends. Parasitol. 22: 439 - 445.
9. Monteiro, A. C, M. Abrahamson, A. P. Lima, M. A. Vannier- Santos, and J. Scharfstein. 2001. Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi. J. Cell Sci. 114: 3933-3942.
10. Myskova, J., J. Votypka, and P. Volf. 2008. Leishmania in sand flies: comparison of quantitative polymerase chain reaction with other techniques to determine the intensity of infection. J. Med. Entomol. 45: 133-138.
11. Pimenta, P.F.P., G. B. Modi, S. T. Pereira, M. Shahabuddin, and D. L. Sacks. 1997. A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut. Parasitology 115: 359-369.
12. Ramalho-Ortigao, J. M., S. Kamhawi, E. D. Rowton, J. M. Ribeiro, and J. G. Valenzuela. 2003. Cloning and characterization of trypsin- and chymotrypsin-like proteases from the midgut of the sand fly vector Phlebotomus papatasi. Insect. Biochem. Mol. Biol. 33: 163-71.
13. Ramalho-Ortigao, M., R. C. Jochim, J. M Anderson, P. G Lawyer, V. M. Pham, S. Kamhawi, and J. G Valenzuela. 2007. Exploring the midgut transcriptome of Phlebotomus papatasi: comparative analysis of expression profiles of sugar-fed, blood-fed and Leishmania-major-infected sandflies. BMC Genomics 8: 300.
14. Rogers, M. E., T. Ilg, A. V. Nikolaev, M.A.J. Ferguson, and P. A. Bates. 2004. Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature (Lond.) 430: 463-467.
15. Sacks, D. L., G. Modi, E. Rowton, G. Spath, L. Epstein, S. J. Turco, and S. M. Beverley. 2000. The role of phospho- glycans in Leishmania-sand fly interactions. Proc. Natl. Acad. Sci. U.S.A. 97: 406-411.
16. Sanderson, S. J., G. D. Westrop, J. Scharfstein, J. C. Mottram, and G. H. Coombs. 2003. Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens. FEBS Lett. 542: 12-16.
17. Santos, C. C, C. Sant'Anna, A. Terres, N. Cunha-e-Silva, J. Scharfstein, and A.P.C.D. Lima. 2005. Chagasin, the en-dogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells. J. Cell. Sci. 118: 901-915.
18. Santos, C. C, G. H. Coombs, A.P.C.A. Lima, and J. C. Mot- tram. 2007. Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence. Mol. Microbiol. 66: 991-1002.
19. Schlein, Y. and H. Romano. 1986. Leishmania major and L. donovani: effects of proteolytic enzymes of Phlebotomus papatasi (Diptera: Psychodidae). Exp. Parasitol. 66: 376- 380.
20. Schlein, Y., and R. L. Jacobson. 1998. Resistance of Phlebotomus papatasi to infection with Leishmania donovani is modulated by components of the infective bloodmeal. Parasitology 117: 467-473.
21. Tchoupe, J. R., T. Moreau, F. Gauthier, and J. G. Bieth. 1991. Photometric or fluorometric assay of cathepsin-B, ca- thepsin-L and cathepsin-H and papain using substrates with an aminotrifluoromethylcoumarin leaving group. Biochim. Biophys. Acta 1076: 149-151.
22. Telleria, E. L., A. N. Pitaluga, J. R. Ortigao-Farias, A. P. de Araujo, J. M. Ramalho-Ortigao, and Y. M. Traub-Cseko. 2007. Constitutive and blood meal-induced trypsin genes in Lutzomyia longipalpis. Arch. Insect. Biochem. Physiol. 66: 53-63.
23. Volf, P., and J. Myskova. 2007. Sand flies and Leishmania: specific versus permissive vectors. Trends. Parasitol. 23: 91-2.
24. Volf, P., M. Svobodova, and E. Dvorakova. 2001. Bloodmeal digestion and Leishmania major infections in Phlebotomus duboscqi: effect of carbohydrates inhibiting midgut lectin activity. Med. Vet. Entomol. 15: 281-286.
25. Volf, P., J. Hostomska, and I. Rohousova. 2008. Molecular crosstalks in Leisftmamo-sandfly-host relationships. Parasite 15: 237-243.
26. Wolfson, J. L., and L. L. Murdock. 1990. Diversity in digestive proteinase activity among insects. J. Chem. Ecol. 16: 1089-1102.