Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy

Journal of Controlled Release

Volumn 138, Issue 1, 2009, Pages 32-39

  Mélot, Mickaël ^a   Pudney, Paul D A ^a   Williamson, Ann Marie ^a   Caspers, Peter J ^b   Van Der Pol, Andre ^b   Puppels, Gerwin J ^b  

^a UNILEVER RESEARCH   (United Kingdom)

^b River Diagnostics BV   (Netherlands)

Author keywords

Bioavailability; In vivo confocal Raman; Skin; Transdermal delivery; Vibrational spectroscopy

Indexed keywords

AFTER-TREATMENT; BARRIER PROPERTIES; BIOAVAILABILITY; BIOLOGICAL PROCESS; CHEMICAL PENETRATION ENHANCER; CONFOCAL RAMAN SPECTROSCOPY; DELIVERY SYSTEMS; DRUG SOLUBILITY; EFFECT OF CHEMICALS; EX-VIVO; HUMAN SKIN; IN VIVO CONFOCAL RAMAN; IN-VITRO; IN-VIVO; MEMBRANE STRUCTURES; PENETRATION ENHANCERS; PROPYLENE GLYCOLS; SKIN CREAMS; TRANSDERMAL DELIVERY; TRITON X-100;

ACIDS; BIOCHEMISTRY; ETHANOL; ETHYLENE GLYCOL; FLEXIBLE STRUCTURES; OLEIC ACID; PROPYLENE; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SKIN; VIBRATIONAL SPECTROSCOPY;

NEEDLES;

ALCOHOL; DECANOIC ACID; MYRITOL 318; OCTANOIC ACID; OLEIC ACID; PENETRATION ENHANCING AGENT; PROPYLENE GLYCOL; RETINOL; TRITON X 100; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CREAM; DRUG FORMULATION; DRUG SOLUBILITY; FOREARM; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MEMBRANE STRUCTURE; NON INVASIVE MEASUREMENT; NORMAL HUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SKIN PENETRATION; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ADULT; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HUMANS; MALE; MIDDLE AGED; OCTOXYNOL; OLEIC ACID; PROPYLENE GLYCOL; SKIN; SKIN ABSORPTION; SPECTRUM ANALYSIS, RAMAN; VITAMIN A; VITAMINS;

EID: 67650119490     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.04.023     Document Type: Article

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