Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients

Nephron - Clinical Practice

Volumn 113, Issue 2, 2009, Pages

  Zheng, Zhen Lon ^a   Hwang, Young Hwan ^b   Kim, Seong Kyun ^c   Kim, Sejoong ^a   Son, Min Jung ^d   Ro, Han ^d   Sung, Su Ah ^b   Lee, Hyun Hee ^a   Chung, Woo Kyung ^a   Joo, Kwon Wook ^d   Yang, Jaeseok ^a  

^a Gachon University   (South Korea)

^b Eulji University   (South Korea)

^c Hallym University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Hemodialysis; Hypoxia inducible factor 1; Single nucleotide polymorphism

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN;

ACUTE HEART INFARCTION; ADULT; AGED; ANEMIA; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; HYPOTENSION; ISCHEMIA; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH KOREA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; COMORBIDITY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INCIDENCE; KIDNEY FAILURE, CHRONIC; KOREA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL DIALYSIS; RISK ASSESSMENT; RISK FACTORS; YOUNG ADULT;

EID: 67650119408     PISSN: 16602110     EISSN: None     Source Type: Journal    
DOI: 10.1159/000228542     Document Type: Article

References (19)

1. Romaldini H, Rodriguez-Roisin R, Lopez FA, Ziegler TW, Bencowitz HZ, Wagner PD: The mechanisms of arterial hypoxemia during hemodialysis. Am Rev Respir Dis 1984; 129: 780-784.
2. Herrero JA, Alvarez-Sala JL, Coronel F, Moratilla C, Gamez C, Sanchez-Alarcos JM, Barrientos A: Pulmonary diffusing capacity in chronic dialysis patients. Respir Med 2002; 96: 487-492.
3. Ke Q, Costa M: Hypoxia-inducible factor- 1 (HIF-1). Mol Pharmacol 2006; 70: 1469-1480.
4. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M: NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF- 1alpha. Nature 2008; 453: 807-811.
5. Nangaku M, Eckardt KU: Hypoxia and the HIF system in kidney disease. J Mol Med 2007; 85: 1325-1330.
6. Hlatky MA, Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, Myers RM, Fortmann SP, Iribarren C, Tabor HK, Assimes TL, Tibshirani RJ, Go AS: Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Am Heart J 2007; 154: 1035-1042.
7. Yamada N, Horikawa Y, Oda N, Iizuka K, Shihara N, Kishi S, Takeda J: Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese. J Clin Endocrinol Metab 2005; 90: 5841-5847. (Pubitemid 41415501)
8. Hong JM, Kim TH, Chae SC, Koo KH, Lee YJ, Park EK, Choi JY, Ryoo HM, Kim SY: Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population. Osteoarthritis Cartilage 2007; 15: 688-694.
9. Ollerenshaw M, Page T, Hammonds J, Demaine A: Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1a) are associated with the renal cell carcinoma phenotype. Cancer Genet Cytogenet 2004; 153: 122-126.
10. Kim JH, Jung CW, Cho YH, Lee J, Lee SH, Kim HY, Park J, Park JO, Kim K, Kim WS, Park YS, Im YH, Kang WK, Park K: Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma. Oncol Rep 2005; 13: 859-864.
11. Imai E, Fujii M, Kohno Y, Kageyama H, Nakahara K, Hori M, Tsubakihara Y: Adenosine a1 receptor antagonist improves intradialytic hypotension. Kidney Int 2006; 69: 877-883.
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
13. Vincent KA, Shyu KG, Luo Y, Magner M, Tio RA, Jiang C, Goldberg MA, Akita GY, Gregory RJ, Isner JM: Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000; 102: 2255-2261.
14. Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM: Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor- 1alpha. Genes Dev 2001; 15: 2520-2532.
15. Kido M, Du L, Sullivan CC, Li X, Deutsch R, Jamieson SW, Thistlethwaite PA: Hypoxiainducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol 2005; 46: 2116-2124.
16. Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR: Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 2006; 577: 705-716.
17. Sun MK, Reis DJ: Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats. Am J Physiol 1994; 266: R245-R256.
18. Belaiba RS, Bonello S, Zahringer C, Schmidt S, Hess J, Kietzmann T, Gorlach A: Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells. Mol Biol Cell 2007; 18: 4691-4697.
19. Percy MJ, Furlow PW, Lucas GS, Li X, Lappin TR, McMullin MF, Lee FS: A gain-of-function mutation in the HIF2a gene in familial erythrocytosis. New Engl J Med 2008; 358: 162-168.