The SUMO arena goes mitochondrial with MAPL

EMBO Reports

Volumn 10, Issue 7, 2009, Pages 694-696

  Scorrano, Luca ^a,b   Liu, Dan ^a,c  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DYNAMIN; DYNAMIN RELATED PROTEIN 1; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; MITOFUSIN 2; PROTEIN MAPL; SUMO PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CELL METABOLISM; CELL MIGRATION; CELL ULTRASTRUCTURE; INTRACELLULAR TRANSPORT; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SUMOYLATION; UBIQUITINATION;

ANIMALS; DYNAMINS; MITOCHONDRIA; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TRANSCRIPTION FACTORS; UBIQUITINATION;

EID: 67650087884     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.141     Document Type: Article

References (20)

1. Affaitati A, Cardone L, de Cristofaro T, Carlucci A, Ginsberg MD, Varrone S, Gottesman ME, Avvedimento EV, Feliciello A (2003) Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria. J Biol Chem 278: 4286-4294
2. Braschi E, Zunino R, McBride HM (2009) MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission. EMBO Rep 10: 748-754
3. Cereghetti GM, Stangherlin A, de Brito OM, Chang CR, Blackstone C, Bernardi P, Scorrano L (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci USA 105: 15803-15808
4. de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456: 605-610
5. Dimmer KS, Scorrano L (2006) (De)constructing mitochondria: What for? Physiology 21: 233-241
6. Frey TG, Mannella CA (2000) The internal structure of mitochondria. Trends Biochem Sci 25: 319-324
7. Harder Z, Zunino R, McBride H (2004) Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission. Curr Biol 14: 340-345
8. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67: 425-479
9. Jahani-Asl A, Slack RS (2007) The phosphorylation state of Drp1 determines cell fate. EMBO Rep 8: 912-913
10. Karbowski M, Neutzner A, Youle RJ (2007) The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol 178: 71-84
11. Magnani M, Serafini G, Antonelli A, Malatesta M, Gazzanelli G (1991) Evidence for a particulate location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain. J Biol Chem 266 21018-21024
12. Nakamura N, Kimura Y, Tokuda M, Honda S, Hirose S (2006) MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep 7: 1019-1022
13. Neuspiel M, Schauss AC, Braschi E, Zunino R, Rippstein P, Rachubinski RA, Andrade-Navarro MA, McBride HM (2008) Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr Biol 18: 102-108
14. Neutzner A, Benard G, Youle RJ, Karbowski M (2008) Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Ann NY Acad Sci 1147: 242-253
15. Schwartz AL, Trausch JS, Ciechanover A, Slot JW, Geuze H (1992) Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells. Proc Natl Acad Sci USA 89: 5542-5546
16. van der Bliek AM (2000) A mitochondrial division apparatus takes shape. J Cell Biol 151: F1-F4
17. Verger A, Perdomo J, Crossley M (2003) Modification with SUMO. A role in transcriptional regulation. EMBO Rep 4: 137-142
18. Werner ED, Brodsky JL, McCracken AA (1996) Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate. Proc Natl Acad Sci USA 93: 13797-13801
19. Yonashiro R et al (2006) A novel mitochondrial ubiquitin ligase, plays a critical role in mitochondrial dynamics. EMBO J 25: 361-3626
20. Zunino R, Schauss A, Rippstein P, Andrade-Navarro M, McBride HM (2007) The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J Cell Sci 120: 1178-1188