Active middle-aged men have lower fasting inflammatory markers but the postprandial inflammatory response is minimal and unaffected by physical activity status

Journal of Applied Physiology

Volumn 107, Issue 1, 2009, Pages 63-68

  Dixon, Natalie C ^a   Hurst, Tina L ^b   Talbot, Duncan C S ^b   Tyrrell, Rex M ^c   Thompson, Dylan ^a  

^a University of Bath   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c UNIVERSITY OF BATH   (United Kingdom)

Author keywords

Cannula; Exercise; Interleukin 6

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; INSULIN; INTERLEUKIN 6; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE MARKER; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; METABOLIC PARAMETERS; MIDDLE AGED; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

BIOLOGICAL MARKERS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; EXERCISE; FOOD DEPRIVATION; HUMANS; INSULIN; INTERLEUKIN-6; MALE; MIDDLE AGED; MOTOR ACTIVITY; POSTPRANDIAL PERIOD; TRIGLYCERIDES;

EID: 67650084402     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91532.2008     Document Type: Article

References (34)

1. Bae JH, Bassenge E, Kim KB, Kim YN, Kim KS, Lee HJ, Moon KC, Lee MS, Park KY, Schwemmer M. Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress. Atherosclerosis 155: 517-523, 2001.
2. Ceriello A, Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Esposito K, Giugliano D. Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes 53: 701-710, 2004.
3. Corpeleijn E, Saris WH, Jansen EH, Roekaerts PM, Feskens EJ, Blaak EE. Postprandial interleukin-6 release from skeletal muscle in men with impaired glucose tolerance can be reduced by weight loss. J Clin Endocrinol Metab 90: 5819-5824, 2005.
4. Department of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: National Center for Chronic Disease Prevention and Health, 1996.
5. Durnin JVGA, Womersle. J. Body fat assessed from total body density and its estimation from skinfold thickness - measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77-97, 1974.
6. Erridge C, Attina T, Spickett CM, Webb DJ. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 86: 1286-1292, 2007.
7. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome - The Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-47, 2000.
8. Gill JM, Caslake MJ, McAllister C, Tsofliou F, Ferrell WR, Packard CJ, Malkova D. Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. J Clin Endocrinol Metab 88: 4328-35, 2003.
9. Gill JMR, Al-Mamari A, Ferrell WR, Cleland SJ, Packard CJ, Sattar N, Petrie JR, Caslake MJ. Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. J Am Coll Cardiol 44: 2375-2382, 2004.
10. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 100: 93-99, 2005.
11. Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmacher T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Psychoneuroendocrinology 27: 921-931, 2002.
12. Hardman AE, Lawrence JEM, Herd SL. Postprandial lipemia in endurance-trained people during a short interruption to training. J Appl Physiol 84: 1895-1901, 1998.
13. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 265: 621-626, 1990.
14. Jellema A, Plat J, Mensink RP. Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. Eur J Clin Invest 34: 766-773, 2004.
15. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 83: 456S-460S, 2006.
16. Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 45: 1563-1569, 2005.
17. Merrill JR, Holly RG, Anderson RL, Rifai N, King ME, Demeersman R. Hyperlipemic response of young trained and untrained men after a high-fat meal. Arteriosclerosis 9: 217-223, 1989.
18. Miyashita M, Burns SF, Stensel DJ. Accumulating short bouts of brisk walking reduces postprandial plasma triacylgerol concentrations and resting blood pressure in healthy young men. Am J Clin Nutr 88: 1225-1231, 2008.
19. Nappo F, Esposito K, Cioffi M, Giugliano G, Molinari AM, Paolisso G, Marfella R, Giugliano D. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol 39: 1145-1150, 2002.
20. Panagiotakos DB, Pitsavos C, Chrysohoou C, Kavouras S, Stefanadis C. The associations between leisure-time physical activity and inflammatory and coagulation markers related to cardiovascular disease: the ATTICA Study. Prev Med 40: 432-437, 2005.
21. Pitsavos C, Chrysohoou C, Panagiotakos DB, Skoumas J, Zeimbekis A, Kokkinos P, Stefanadis C, Toutouzas PK. Association of leisure-time physical activity on inflammation markers (C-reactive protein, white cell blood count, serum amyloid A, and fibrinogen,) in healthy subjects (from the ATTICA study). Am J Cardiol 91: 368-370, 2003.
22. Pocock SJ, Ashby D, Shaper AG, Walker M, Broughton PM. Diurnal variations in serum biochemical and haematological measurements. J Clin Pathol 42: 172-179, 1989.
23. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342: 836-843, 2000.
24. Ridker PM, Wilson PWF, Grundy SM. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation 109: 2818-2825, 2004.
25. Rothenbacher D, Hoffmeister A, Brenner H, Koenig W. Physical activity, coronary heart disease, and inflammatory response. Arch Intern Med 163: 1200-1205, 2003.
26. Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, Holloszy JO. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol 56: 1521-1525, 1984.
27. Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 281: 1722-1727, 1999.
28. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK. T-Lymphocytes from human atherosclerotic plaques recognize oxidized low-density-lipoprotein. Proc Natl Acad Sci USA 92: 3893-3897, 1995.
29. Thompson D, Batterham AM, Bock S, Robson C, Stokes K. Assessment of low-to-moderate intensity physical activity thermogenesis in young adults using synchronized heart rate and accelerometry with branched-equation modeling. J Nutr 136: 1037-1042, 2006.
30. van Oostrom AJ, Sijmonsma TP, Verseyden C, Jansen EH, de Koning EJ, Rabelink TJ, Castro Cabezas M. Postprandial recruitment of neutrophils may contribute to endothelial dysfunction. J Lipid Res 44: 576-583, 2003.
31. van Oostrom AJ, Rabelink TJ, Verseyden C, Sijmonsma TP, Plokker HW, De Jaegere PP, Cabezas MC. Activation of leukocytes by postprandial lipemia in healthy volunteers. Atherosclerosis 177: 175-182, 2004.
32. Vasankari TJ, Kujala UM, Vasankari TM, Ahotupa M. Reduced oxidized LDL levels after a 10-month exercise program. Med Sci Sports Exerc 30: 1496-1501, 1998.
33. Wright E Jr, Scism-Bacon JL, Glass LC. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract 60: 308-314, 2006.
34. You T, Berman DM, Ryan AS, Nicklas BJ. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J Clin Endocrinol Metab 89: 1739-1746, 2004.