Hypothalamic paraventricular nucleus mediates sodium-induced changes in cardiovascular and renal function in conscious sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 1, 2009, Pages

  Frithiof, Robert ^a,b   Ramchandra, Rohit ^b   Hood, Sally ^b   May, Clive ^b   Rundgren, Mats ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Angiotensin II; Hypertension; Hypertonic NACL; Hypothalamus; Intracerebroventricular; RSNA; Sympathetic nerve activity

Indexed keywords

ANGIOTENSIN II; CREATININE; GLYCINE; LIDOCAINE; SODIUM; SODIUM CHLORIDE;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTERIAL PRESSURE; ARTICLE; CARDIOVASCULAR FUNCTION; CENTRAL VENOUS PRESSURE; CEREBROSPINAL FLUID LEVEL; CONSCIOUSNESS; CONTROLLED STUDY; CREATININE CLEARANCE; FEMALE; FREE WATER CLEARANCE; GLOMERULUS FILTRATION RATE; HEART OUTPUT; HEART RATE; KIDNEY FUNCTION; KIDNEY NERVE; MICTURITION; NONHUMAN; PRIORITY JOURNAL; SHEEP; SODIUM URINE LEVEL; SYMPATHETIC TONE;

ANESTHETICS, LOCAL; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; CENTRAL VENOUS PRESSURE; CONSCIOUSNESS; CREATININE; FEMALE; GLOMERULAR FILTRATION RATE; GLYCINE; HEART RATE; HEMODYNAMICS; HOMEOSTASIS; INFUSIONS, PARENTERAL; INJECTIONS; KIDNEY; LIDOCAINE; NATRIURESIS; OSMOLAR CONCENTRATION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; SALINE SOLUTION, HYPERTONIC; SHEEP; SODIUM; SYMPATHETIC NERVOUS SYSTEM; URODYNAMICS;

EID: 67650081007     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00058.2008     Document Type: Article

References (47)

1. Anderson JW, Smith PM, Ferguson AV. Subfornical organ neurons projecting to paraventricular nucleus: whole-cell properties. Brain Res 921: 78-85, 2001. (Pubitemid 33096286)
2. Andersson B, Dallman MF, Olsson K. Observations on central control of drinking and of the release of antidiuretic hormone (ADH). Life Sci 8: 425-432, 1969.
3. Andersson B, Eriksson L, Fernandez O, Kolmodin CG, Oltner R. Centrally mediated effects of sodium and angiotensin II on arterial blood pressure and fluid balance. Acta Physiol Scand 85: 398-407, 1972.
4. Andersson B, Jobin M, Olsson K. Stimulation of urinary salt excretion following injections of hypertonic NaCl-solution into the 3rd brain ventricle. Acta Physiol Scand 67: 127-128, 1966.
5. Antunes VR, Yao ST, Pickering AE, Murphy D, Paton JF. A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympathoexcitation. J Physiol 576: 569-583, 2006. (Pubitemid 44490146)
6. Badoer E, Ng CW, De Matteo R. Glutamatergic input in the PVN is important in renal nerve response to elevations in osmolality. Am J Physiol Renal Physiol 285: F640-F650, 2003. (Pubitemid 37140248)
7. Badoer E, Ng CW, De Matteo R. Tonic sympathoinhibition arising from the hypothalamic PVN in the conscious rabbit. Brain Res 947: 17-24, 2002. (Pubitemid 34876511)
8. Brooks VL, Haywood JR, Johnson AK. Translation of salt retention to central activation of the sympathetic nervous system in hypertension. Clin Exp Pharmacol Physiol 32: 426-432, 2005. (Pubitemid 40780270)
9. Buggy J, Hoffman WE, Phillips MI, Fisher AE, Johnson AK. Osmosensitivity of rat third ventricle and interactions with angiotensin. Am J Physiol Regul Integr Comp Physiol 236: R75-R82, 1979. (Pubitemid 9098031)
10. 1-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitation. Am J Physiol Regul Integr Comp Physiol 281: R1844-R1853, 2001.
11. Denton D, Weisinger R, Mundy NI, Wickings EJ, Dixson A, Moisson P, Pingard AM, Shade R, Carey D, Ardaillou R. The effect of increased salt intake on blood pressure of chimpanzees. Nat Med 1: 1009-1016, 1995.
12. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev 77: 75-197, 1997.
13. Dickinson HO, Mason JM, Nicolson DJ, Campbell F, Beyer FR, Cook JV, Williams B, Ford GA. Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials. J Hypertens 24: 215-233, 2006. (Pubitemid 43348227)
14. Eriksson L, Fyhrquist F. Plasma renin activity following central infusion of angiotensin II and altered CSF sodium concentration in the conscious goat. Acta Physiol Scand 98: 209-216, 1976.
15. 1 and glutamatergic receptors in paraventricular nucleus support blood pressure during water deprivation. Am J Physiol Regul Integr Comp Physiol 292: R1675-R1682, 2007.
16. Frithiof R, Eriksson S, Bayard F, Svensson T, Rundgren M. Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep. J Physiol 583: 1129-1143, 2007. (Pubitemid 47423722)
17. Frithiof R, Mats R, Johan U, Stefan E, Hans H. Comparison between the effects on hemodynamic responses of central and peripheral infusions of hypertonic NaCl during hemorrhage in conscious and isofluraneanesthetized sheep. Shock 26: 77-86, 2006. (Pubitemid 44297010)
18. Guadagnini D, Gontijo JA. Altered renal sodium handling in spontaneously hypertensive rats (SHR) after hypertonic saline intracerebroventricular injection: role of renal nerves. Life Sci 79: 1666-1673, 2006. (Pubitemid 44363089)
19. Intersalt Cooperative Research Group. An international study of electrolyte excretion, and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 297: 319-328, 1988.
20. Katahira K, Mikami H, Ogihara T, Kohara K, Otsuka A, Kumahara Y, Khosla MC. Synergism of intraventricular NaCl infusion and subpressor angiotensins in rats. Am J Physiol Heart Circ Physiol 256: H1-H8, 1989. (Pubitemid 19049879)
21. Kawano Y, Ferrario CM. Neurohormonal characteristics of cardiovascular response due to intraventricular hypertonic NaCl. Am J Physiol Heart Circ Physiol 247: H422-H428, 1984. (Pubitemid 14047355)
22. Kawano Y, Sudo RT, Ferrario CM. Effects of chronic intraventricular sodium on blood pressure and fluid balance. Hypertension 17: 28-35, 1991.
23. Kenney MJ, Weiss ML, Patel KP, Wang Y, Fels RJ. Paraventricular nucleus bicuculline alters frequency components of sympathetic nerve discharge bursts. Am J Physiol Heart Circ Physiol 281: H1233-H1241, 2001. (Pubitemid 32879261)
24. Larsen PJ, Mikkelsen JD. Functional identification of central afferent projections conveying information of acute "stress" to the hypothalamic paraventricular nucleus. J Neurosci 15: 2609-2627, 1995.
25. Luiten PG, ter Horst GJ, Karst H, Steffens AB. The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res 329: 374-378, 1985.
26. Martin DS, Egland MC, Barnes LU, Vogel EM. Adrenergic nerves mediate the venoconstrictor response to PVN stimulation. Brain Res 1076: 93-100, 2006. (Pubitemid 43376027)
27. Martin DS, Rodrigo MC, Appelt CW. Venous tone in the developmental stages of spontaneous hypertension. Hypertension 31: 139-144, 1998. (Pubitemid 28124706)
28. May CN, McAllen RM. Baroreceptor-independent renal nerve inhibition by intracerebroventricular angiotensin II in conscious sheep. Am J Physiol Regul Integr Comp Physiol 273: R560-R567, 1997. (Pubitemid 27428067)
29. May CN, McAllen RM. Brain angiotensinergic pathways mediate renal nerve inhibition by central hypertonic NaCl in conscious sheep. Am J Physiol Regul Integr Comp Physiol 272: R593-R600, 1997. (Pubitemid 27142682)
30. May CN, McAllen RM, McKinley MJ. Renal nerve inhibition by central NaCl and ANG II is abolished by lesions of the lamina terminalis. Am J Physiol Regul Integr Comp Physiol 279: R1827-R1833, 2000.
31. McKinley MJ, Denton DA, Coghlan JP, Harvey RB, McDougall JG, Rundgren M, Scoggins BA, Weisinger RS. Cerebral osmoregulation of renal sodium excretion-a response analogous to thirst and vasopressin release. Can J Physiol Pharmacol 65: 1724-1729, 1987.
32. McKinley MJ, Gerstberger R, Mathai ML, Oldfield BJ, Schmid H. The lamina terminalis and its role in fluid and electrolyte homeostasis. J Clin Neurosci 6: 289-301, 1999.
33. McKinley MJ, Mathai ML. Centrally administered losartan inhibits the reduction in plasma renin concentration caused by intracerebroventricular hypertonic saline in Na-depleted sheep. Regul Pept 66: 37-40, 1996. (Pubitemid 26348986)
34. McKinley MJ, McAllen RM, Davern P, Giles ME, Penschow J, Sunn N, Uschakov A, Oldfield BJ. The sensory circumventricular organs of the mammalian brain. In: Adv Anat Embryol Cell Biol 172: III-XII, 1-122, back cover, 2003.
35. McKinley MJ, McBurnie MI, Mathai ML. Neural mechanisms subserving central angiotensinergic influences on plasma renin in sheep. Hypertension 37: 1375-1381, 2001. (Pubitemid 34225377)
36. Miyajima E, Bunag RD. Enhanced sympathetic pressor responses to intracerebrovascularly infused saline in awake salt-loaded rats. Am J Hypertens 3: 117-122, 1990. (Pubitemid 20131943)
37. Morris M, Campbell WB, Pettinger WA. Renin and hemodynamic changes via central adrenergic, cholinergic, and sodium receptor mechanisms in conscious rats. Proc Soc Exp Biol Med 151: 101-104, 1976.
38. Pyner S, Deering J, Coote JH. Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats. Exp Physiol 87: 25-32, 2002. (Pubitemid 34083244)
39. Shi P, Martinez MA, Calderon AS, Chen Q, Cunningham JT, Toney GM. Intra-carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus. J Physiol 586: 5231-5245, 2008.
40. Shi P, Stocker SD, Toney GM. Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol Regul Integr Comp Physiol 293: R2279-R2289, 2007. (Pubitemid 350224021)
41. Stocker SD, Hunwick KJ, Toney GM. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats. J Physiol 563: 249-263, 2005. (Pubitemid 40340380)
42. Stocker SD, Toney GM. Median preoptic neurones projecting to the hypothalamic paraventricular nucleus respond to osmotic, circulating ANG II and baroreceptor input in the rat. J Physiol 568: 599-615, 2005. (Pubitemid 41555460)
43. Swanson LW, Sawchenko PE. Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology 31: 410-417, 1980. (Pubitemid 11250989)
44. Wang H, Leenen FH. Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure. J Hypertens 21: 1519-1524, 2003. (Pubitemid 36994131)
45. Watson AM, Mogulkoc R, McAllen RM, May CN. Stimulation of cardiac sympathetic nerve activity by central angiotensinergic mechanisms in conscious sheep. Am J Physiol Regul Integr Comp Physiol 286: R1051-R1056, 2004. (Pubitemid 38661392)
46. Weiss ML, Claassen DE, Hirai T, Kenney MJ. Nonuniform sympathetic nerve responses to intravenous hypertonic saline infusion. J Auton Nerv Syst 57: 109-115, 1996. (Pubitemid 26057936)
47. Zucker IH, Levine N, Kaley G. Third ventricular injection of hypertonic NaCl: effect of renal denervation on natriuresis. Am J Physiol 227: 35-41, 1974.