In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 677, Issue 1-2, 2009, Pages 1-7

  Hashizume, Tsuneo ^a   Yoshitomi, Sumie ^a   Asahi, Satoru ^a   Matsumura, Shigeo ^a   Chatani, Fumio ^a   Oda, Hiroaki ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

HepG2 transformants; Human cytochrome P450; In vitro micronucleus test

Indexed keywords

BENZO[A]PYRENE; CYCLOPHOSPHAMIDE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; FURAFYLLINE; OKADAIC ACID; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLIC ACTIVATION; MICRONUCLEUS; MICRONUCLEUS TEST; MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BIOTRANSFORMATION; CELL LINE, TRANSFORMED; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICRONUCLEUS TESTS; MUTAGENS; OKADAIC ACID; PROTEIN ISOFORMS; RNA, SMALL INTERFERING;

RATTUS;

EID: 67650079033     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.03.009     Document Type: Article

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