Pathophysiology of trigeminal autonomic cephalalgias

The Lancet Neurology

Volumn 8, Issue 8, 2009, Pages 755-764

  Leone, Massimo ^a   Bussone, Gennaro ^a  

^a Headache Centre   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

OREXIN 2 RECEPTOR;

CACNA1A GENE; CLINICAL FEATURE; CLUSTER HEADACHE; GENE; GENETIC ASSOCIATION; HUMAN; NEUROIMAGING; POSTERIOR HYPOTHALAMUS; PREVALENCE; PRIORITY JOURNAL; REVIEW; TRIGEMINAL AUTONOMIC CEPHALALGIA;

DIAGNOSTIC IMAGING; HUMANS; HYPOTHALAMUS, POSTERIOR; MODELS, BIOLOGICAL; NEURAL PATHWAYS; TRIGEMINAL AUTONOMIC CEPHALALGIAS;

EID: 67650073226     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70133-4     Document Type: Review

References (115)

1. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edn. Cephalalgia 24 suppl 1 (2004) 1-160
2. Kudrow L. Cluster headache, mechanism and management. 1st edn. (1980), Oxford University Press, New York, NY, USA
3. Sjaastad O. Cluster headache syndrome. In: Sjaastad O. (Ed). Major Problems in Neurology volume 23 (1992), WB Saunders Company Ltd, London, UK
4. Goadsby P.J., and Lipton R.B. A review of paroxysmal hemicranias, SUNCT syndrome and other shortlasting headaches with autonomic feature, including new cases. Brain 120 (1997) 193-209
5. Goadsby P.J. Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurol 1 (2002) 251-257
6. May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet 366 (2005) 843-855
7. Torelli P., Cologno D., Cademartiri C., and Manzoni G.C. Application of the International Headache Society classification criteria in 652 cluster headache patients. Cephalalgia 21 (2001) 145-150
8. Tonon C., Guttmann S., Volpini M., Naccarato S., Cortelli P., and D'Alessandro R. Prevalence and incidence of cluster headache in the Republic of San Marino. Neurology 58 (2002) 1407-1409
9. Sjaastad O., and Bakketeig L.S. Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia 23 (2003) 528-533
10. Fischera M., Marziniak M., Gralow I., and Evers S. The incidence and prevalence of cluster headache: a meta-analysis of population-based studies. Cephalalgia 28 (2008) 614-618
11. Cittadini E., Matharu M.S., and Goadsby P.J. Paroxysmal hemicrania: a prospective clinical study of 31 cases. Brain 131 (2008) 1142-1155
12. Cohen A.S., Matharu M.S., and Goadsby P.J. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)-a prospective clinical study of SUNCT and SUNA. Brain 129 (2006) 2746-2760
13. May A., Bahra A., Buchel C., Frackowiak R.S., and Goadsby P.J. Hypothalamic activation in cluster headache attacks. Lancet 352 (1998) 275-278
14. May A., Ashburner J., Buchel C., et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 5 (1999) 836-838
15. May A., Bahra A., Buchel C., Turner R., and Goadsby P.J. Functional MRI in spontaneous attacks of SUNCT: short-lasting neuralgiform headache with conjunctival injection and tearing. Ann Neurol 46 (1999) 791-793
16. May A., Bahra A., Buchel C., et al. PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 55 (2000) 1328-1335
17. Sprenger T., Boecker H., Toelle T.R., Bussone G., May A., and Leone M. Specific hypothalamic activation during a spontaneous cluster headache attack. Neurology 3 (2004) 516-517
18. Sprenger T., Valet M., Hammes M., et al. Hypothalamic activation in trigeminal autonomic cephalgia: functional imaging of an atypical case. Cephalalgia 24 (2004) 753-757
19. Sprenger T., Valet M., Platzer S., Pfaffenrath V., Steude U., and Tolle T.R. SUNCT: bilateral hypothalamic activation during headache attacks and resolving of symptoms after trigeminal decompression. Pain 113 (2005) 422-426
20. May A., Leone M., Boecker H., et al. Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci 26 (2006) 3589-3593
21. Matharu M.S., Cohen A.S., Frackowiak R.S.J., and Goadsby P.J. Posterior hypothalamic activation in paroxysmal hemicrania. Ann Neurol 59 (2006) 535-545
22. Sprenger T., Willoch F., Miederer M., et al. Opioidergic changes in the pineal gland and hypothalamus in cluster headache: a ligand PET study. Neurology 66 (2006) 1108-1110
23. Cohen A.S. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. Cephalalgia 27 (2007) 824-832
24. Sprenger T., Ruether K.V., Boecker H., et al. Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia 27 (2007) 1033-1042
25. Leone M., Franzini A., and Bussone G. Stereotactic stimulation of posterior hypothalamic gray matter for intractable cluster headache. N Engl J Med 345 (2001) 1428-1429
26. Leone M., Franzini A., Broggi G., May A., and Bussone G. Long-term follow up of bilateral hypothalamic stimulation for intractable cluster headache. Brain 127 (2004) 2259-2264
27. Schoenen J., Di Clemente L., Vandenheede M., et al. Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 128 (2005) 940-947
28. Leone M., Franzini A., Broggi G., and Bussone G. Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology 67 (2006) 150-152
29. Owen S.L.F., Green A.L., Davies P., et al. Connectivity of an effective hypothalamic surgical target for cluster headache. J Clin Neurosci 14 (2007) 955-960
30. Starr P.A., Barbaro N.M., Raskin N.H., and Ostrem J.L. Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg 106 (2007) 999-1005
31. Bartsch T., Pinsker M.O., Rasche D., et al. Hypothalamic deep brain stimulation for cluster headache-experience from a new multicase series. Cephalalgia 28 (2008) 285-295
32. Magis D., Allena M., Bolla M., De Pasqua V., Remacle J.M., and Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol 6 (2007) 314-321
33. Burns B., Watkins L., and Goadsby P.J. Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients. Lancet 369 (2007) 1099-1106
34. Waldenlind E., Gustafsson S.A., Ekbom K., and Wetterberg L. Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission. J Neurol Neurosurg Psychiatry 50 (1987) 207-213
35. Leone M., and Bussone G. A review of hormonal findings in cluster headache. Evidence for hypothalamic involvement. Cephalalgia 13 (1993) 309-317
36. Couturier E.G., Hering R., and Steiner T.J. The first report of cluster headache in identical twins. Neurology 41 (1991) 761
37. Sjaastad O., Shen J.M., Stovner L.J., and Elsas T. Cluster headache in identical twins. Headache 33 (1993) 214-217
38. Kudrow L., and Kudrow D.B. Inheritance of cluster headache and its possible link to migraine. Headache 34 (1994) 400-407
39. Russell M.B., Andersson P.G., and Thomsen L.L. Familial occurrence of cluster headache. J Neurol Neurosurg Psychiatry 58 (1995) 341-343
40. Leone M., Russell M.B., Rigamonti A., et al. Increased familial risk of cluster headache. Neurology 56 (2001) 1233-1236
41. Russell M.B., Andersson P.G., Thomsen L.L., and Iselius L. Cluster headache is an autosomal dominantly inherited disorder in some families: a complex segregation analysis. J Med Genet 32 (1995) 954-956
42. Cortelli P., Zacchini A., Barboni P., Malpassi P., Carelli V., and Montagna P. Lack of association between mitochondrial tRNA(Leu(UUR)) point mutation and cluster headache. Lancet 345 (1995) 1120-1121
43. Sjöstrand C., Modin H., Masterman T., Ekbom K., Waldenlind E., and Hillert J. Analysis of nitric oxide synthase genes in cluster headache. Cephalalgia 22 (2002) 758-764
44. Sjöstrand C., Giedratis V., Ekbom K., Waldenlind E., and Hillert J. CACNA1A gene polymorphisms in cluster headache. Cephalalgia 21 (2001) 953-958
45. Rainero I., Rivoiro C., Gallone S., et al. Lack of association between the 3092 T→C clock gene polymorphism and cluster headache. Cephalalgia 25 (2005) 1078-1081
46. Cevoli S., Mochi M., Pierangeli G., et al. Investigation of the T3111C CLOCK gene polymorphism in cluster headache. J Neurol 255 (2008) 299-300
47. Bartsch T., Levy M.J., Knight Y.E., and Goadsby P.J. Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area. Pain 109 (2004) 367-378
48. Rainero I., Gallone S., Valfre W., et al. A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. Neurology 63 (2004) 1286-1288
49. Schürks M., Kurth T., Geissler I., Tessmann G., Diener H.C., and Rosskopf D. Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene. Neurology 66 (2006) 1917-1919
50. Baumber L., Sjöstrand C., Leone M., et al. A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. Neurology 66 (2006) 1888-1893
51. Leone M., Mea E., Genco S., and Bussone G. Coexistence of TACs and trigeminal neuralgia: pathophysiological conjectures. Headache 46 (2006) 1565-1570
52. Goadsby P.J., and Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 117 (1994) 427-434
53. Goadsby P.J., and Edvinsson L. Neuropeptide changes in a case of chronic paroxysmal hemicrania-evidence for trigemino-parasympathetic activation. Cephalalgia 16 (1996) 448-450
54. Goadsby P.J., Edvinsson L., and Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28 (1990) 183-187
55. Goadsby P.J., Edvinsson L., and Ekman R. Release of vasoactive peptides in the extracerebral circulation of man and the cat during activation of the trigeminovascular system. Ann Neurol 23 (1988) 193-196
56. Matharu M.S., Cohen A.S., Boes C.J., and Goadsby P.J. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing syndrome: a review. Curr Pain Headache Rep 7 (2003) 308-318
57. Matharu M.S., Boes C.J., and Goadsby P.J. Management of trigeminal autonomic cephalgias and hemicrania continua. Drugs 63 (2003) 1637-1677
58. Prakash S., Dholakia S.Y., and Shah K.A. A patient with chronic cluster headache responsive to high-dose indomethacin: is there an overlap with chronic paroxysmal hemicrania?. Cephalalgia 28 (2008) 778-781
59. Leone M., D'Amico D., Frediani F., Moschiano F., Grazzi L., Attanasio A., and Bussone G. Verapamil in the prophylaxis of episodic cluster headache: a double-blind study vs. placebo. Neurology 54 (2000) 1382-1385
60. Narbone M.C., Gangemi S., and Abbate M. A case of SUNCT syndrome responsive to verapamil. Cephalalgia 25 (2005) 476-478
61. Shabbir N., and McAbee G. Adolescent chronic paroxysmal hemicrania responsive to verapamil monotherapy. Headache 34 (1994) 209-210
62. Leone M., Dodick D., Rigamonti A., et al. Topiramate in cluster headache prophylaxis: an open trial. Cephalalgia 23 (2003) 1001-1002
63. Pascual J., Láinez M.J., Dodick D., and Hering-Hanit R. Antiepileptic drugs for the treatment of chronic and episodic cluster headache: a review. Headache 47 (2007) 81-89
64. Matharu M.S., Boes C.J., and Goadsby P.J. SUNCT syndrome: prolonged attacks, refractoriness and response to topiramate. Neurology 58 (2002) 1307
65. Rossi P., Cesarino F., Faroni J., et al. SUNCT syndrome successfully treated with topiramate: case reports. Cephalalgia 23 (2003) 998-1000
66. Evers S., and Husstedt I.W. Alternatives in drug treatment of chronic paroxysmal hemicrania. Headache 36 (1996) 429-432
67. Cohen A.S., and Goadsby P.J. Paroxysmal hemicrania responding to topiramate. J Neurol Neurosurg Psychiatry 78 (2007) 96-97
68. Camarda C., Camarda R., and Monastero R. Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: two case reports. Clin Neurol Neurosurg 110 (2008) 88-91
69. Pascual J., and Quijano J. A case of chronic paroxysmal hemicrania responding to subcutaneous sumatriptan. J Neurol Neurosurg Psychiatry 65 (1998) 407
70. Leone M., Franzini A., D'Andrea G., Broggi G., Casucci G., and Bussone G. Deep brain stimulation to relieve severe drug-resistant SUNCT. Ann Neurol 57 (2005) 924-927
71. Lyons M.K., Dodick D.W., and Evidente V.G. Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg 26 (2008) 1-3
72. Hardebo J.E. How cluster headache is explained as an intracavernous inflammatory process lesioning sympathetic fibers. Headache 34 (1994) 125-131
73. Bovim G., Jenssen G., and Ericson K. Orbital phlebography: a comparison between cluster headache and other headaches. Headache 32 (1992) 408-412
74. Remahl I.N., Waldenlind E., Bratt J., and Ekbom K. Cluster headache is not associated with signs of a systemic inflammation. Headache 40 (2000) 276-281
75. May A., Buchel C., Turner R., and Goadsby P.J. Magnetic resonance angiography in facial and other pain: neurovascular mechanisms of trigeminal sensation. J Cereb Blood Flow Metab 21 (2001) 1171-1176
76. Matharu M.S., and Goadsby P.J. Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 125 (2002) 976-984
77. Jarrar R.G., Black D.F., Dodick D.W., and Davis D.H. Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 60 (2003) 1360-1362
78. The Sumatriptan Cluster Headache Study Group. Treatment of acute cluster headache with sumatriptan. N Engl J Med 325 (1991) 322-326
79. Moskowitz M.A. Basic mechanisms in vascular headache. Neurol Clin 8 (1990) 801-815
80. Favier I., van Vliet J.A., Roon K.I., et al. Trigeminal autonomic cephalgias due to structural lesions: a review of 31 cases. Arch Neurol 64 (2007) 25-31
81. Leone M., Curone M., Mea E., and Bussone G. Cluster-tic syndrome resolved by removal of pituitary adenoma: the first case. Cephalalgia 24 (2004) 1088-1089
82. Levy M., Matharu M.S., Meeran K., et al. The clinical characteristics of headache in patients with pituitary tumours. Brain 128 (2005) 1921-1930
83. Leone M., Attanasio A., Croci D., et al. The m-chlorophenylpiperazine test in cluster headache: a study on central serotoninergic activity. Cephalalgia 17 (1997) 666-672
84. Riederer F., Selekler H.M., Sándor P.S., and Wöber C. Cutaneous allodynia during cluster headache attacks. Cephalalgia 29 (2009) 796-798
85. Rozen T.D., Haynes G.V., Saper J.R., and Sheftell F.D. Abrupt onset and termination of cutaneous allodynia (central sensitization) during attacks of SUNCT. Headache 45 (2005) 153-155
86. Lin H., and Dodick D.W. Tearing without pain after trigeminal root section for cluster headache. Neurology 65 (2005) 1650-1651
87. Black D.F., and Dodick D.W. Two cases of medically and surgically intractable SUNCT: a reason for caution and an argument for a central mechanism. Cephalalgia 22 (2002) 201-204
88. Bartsch T., Knight Y.E., and Goadsby P.J. Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception. Ann Neurol 56 (2004) 371-381
89. 1D agonist sumatriptan. Eur Neuropsychopharmacol 8 (1998) 325-328
90. Veloso F., Kumar K., and Toth C. Headache secondary to deep brain implantation. Headache 38 (1998) 507-605
91. Leone M. Deep brain stimulation in headache. Lancet Neurol 5 (2006) 873-877
92. Leone M., Franzini A., Broggi G., May A., and Bussone G. Therapeutic stimulation of the hypothalamus: pathophysiological insights and prerequisites for management. Brain 128 (2005) E35
93. Frese A., Evers S., and May A. Autonomic activation in experimental trigeminal pain. Cephalalgia 23 (2003) 67-68
94. Drummond P.D. Autonomic disturbances in cluster headache. Brain 111 (1988) 1199-1209
95. Russell M.B., and Andersson P.G. Clinical intra- and interfamilial variability of cluster headache. Eur J Neurol 1 (1995) 253-257
96. Leone M., Rigamonti A., and Bussone G. Cluster headache sine headache: two new cases in one family. Cephalalgia 22 (2002) 12-14
97. Pareja J.A. Chronic paroxysmal hemicrania: dissociation of the pain and autonomic features. Headache 35 (1995) 111-113
98. Lodi R., Pierangeli G., Tonon C., et al. Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy. Neurology 66 (2006) 1264-1266
99. Wang S.J., Lirng J.F., Fuh J.L., and Chen J.J. Reduction in hypothalamic 1H-MRS metabolite ratios in patients with cluster headache. J Neurol Neurosurg Psychiatry 77 (2006) 622-625
100. Matharu M., and May A. Functional and structural neuroimaging in trigeminal autonomic cephalalgias. Curr Pain Headache Rep 12 (2008) 132-137
101. Matharu M.S., Cohen A.S., McGonigle D.J., et al. Posterior hypothalamic and brainstem activation in hemicrania continua. Headache 44 (2004) 747-761
102. Sánchez del Río M., Hernández J.A., Caminero A.B., Pareja J.A., and Linera J.A. Activacion subcortical en SUNCT y V-1 con resonancia funcional. Neurologia 18 (2003) 517 (in Spanish).
103. Denuelle M., Fabre N., Payoux P., Chollet F., and Geraud G. Hypothalamic activation in spontaneous migraine attacks. Headache 47 (2007) 1418-1426
104. Dubé A.A., Duquette M., Roy M., Lepore F., Duncan G., and Rainville P. Brain activity associated with the electrodermal reactivity to acute heat pain. NeuroImage 45 (2009) 169-180 1
105. Petrovic P., Petersson K.M., Hansson P., and Ingvara M. Brainstem involvement in the initial response to pain. NeuroImage 22 (2004) 995-1005
106. Malick A., Strassman A.M., and Burstein R. Trigeminohypothalamic and reticulohypothalamic tract neurons in the upper cervical spinal cord and caudal medulla of the rat. J Neurophysiol 84 (2000) 2078-2112
107. de Lecea L., Kilduff T.S., Peyron C., et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95 (1998) 322-327
108. Holland P., and Goadsby P.J. The hypothalamic orexinergic system: pain and primary headaches. Headache 47 (2007) 951-962
109. Das P., Bell-Horner C.L., Huang R.Q., et al. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience 124 (2004) 195-206
110. Sano K., Sekino H., Hashimoto I., Amano K., and Sugiyama H. Posteromedial hypothalamotomy in the treatment of intractable pain. Confin Neurol 37 (1975) 285-290
111. Leone M., Franzini A., Broggi G., Mea E., Cecchini A.P., and Bussone G. Acute hypothalamic stimulation and ongoing cluster headache attacks. Neurology 67 (2006) 1844-1845
112. Jürgens T., Busch V., Leone M., et al. Modulation des nociceptiven Systems durch Tiefenhirnstimulation des posterioren Hypothalamus bei Clusterkopfschmerz. Schmerz 1 (2007) 104-105 (in German).
113. Holle D., Obermann M., and Katsarava Z. The electrophysiology of cluster headache. Curr Pain Head Rep 13 (2009) 155-159
114. Cortelli P., Guaraldi P., Leone M., et al. Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients. Eur J Neurol 14 (2007) 1008-1015
115. Sandor P.S., Irimia P., Jager H.R., Goadsby P.J., and Kaube H. Onset of cluster headache triggered by emotional effect: a case report. J Neurol Neurosurg Psychiatry 77 (2006) 1097-1099