Reduction in hypothalamic1H-MRS metabolite ratios in patients with cluster headache

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 77, Issue 5, 2006, Pages 622-625

  Wang, S J ^a,b   Lirng, J F ^a   Fuh, J L ^a,b   Chen, J J ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID; ASPARTIC ACID; CREATININE; DRUG DERIVATIVE; N-ACETYLASPARTATE;

ADULT; ARTICLE; CLUSTER HEADACHE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; FOLLOW UP; HUMAN; HYPOTHALAMUS; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REMISSION; TRANSFORMED MIGRAINE; CHRONIC DISEASE; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; HEMISPHERIC DOMINANCE; IMAGE PROCESSING; METABOLISM; MIDDLE AGED; MIGRAINE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; REFERENCE VALUE; STATISTICS;

ADULT; ASPARTIC ACID; CHOLINE; CHRONIC DISEASE; CLUSTER HEADACHE; CREATININE; DIAGNOSIS, DIFFERENTIAL; DOMINANCE, CEREBRAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOTHALAMUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MIGRAINE DISORDERS; REFERENCE VALUES; STATISTICS;

EID: 33646901105     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2005.081836     Document Type: Article

References (20)

1. May A, Bahra A, Büchel C, et al. Hypothalamic activation in cluster headache attacks. Lancet 1998;352:275-8.
2. May A, Ashburner J, Büchel C, et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999;5:836-8.
3. Peres MF, Sanchez del Rio M, Seabra ML, et al. Hypothalamic involvement in chronic migraine. J Neurol Neurosurg Psychiatry 2001;71:747-51.
4. Denuelle M, Fabre N, Payoux P, et al. Brainstem and hypothalamic activation in spontaneous migraine attacks: a PET study. Cephalalgia 2004;24:782.
5. Rudkin TM, Arnold DL. Proton magnetic resonance spectroscopy for the diagnosis and management of cerebral disorders. Arch Neurol 1999;56:919-26.
6. Michaelis T, Merboldt KD, Hanicke W, et al. On the identification of cerebral metabolites in localized 1H NMR spectra of human brain in vivo. NMR Biomed 1991;4:90-8.
7. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001;14:260-4.
8. Safriel Y, Pol-Rodriguez MA, Novotny EJ, et al. Reference values for long echo time MR spectroscopy in healthy adults. AJNR Am J Neuroradiol 2005;26:1439-45.
9. Bates TE, Strangward M, Keelan J, et al. Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport 1996;7:1397-400.
10. Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58.
11. Miller BL. A review of chemical issues in 1H NMR spectroscopy: N-acelyl-L-aspartate, creatine and choline. NMR Biomed 1991;4:47-52.
12. Cox IJ. Development and applications of in vivo clinical magnetic resonance spectroscopy. Prog Biophys Mol Biol 1996;65:45-81.
13. Lodi R, Tonon C, Vignattelli L, et al. In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients. Neurology 2004;63:1513-15.
14. Lodi R, Pierangeli G, Tonon C. Hypothalamus metabolism studied in cluster headache patients by proton MR spectroscopy [abstract]. Ann Neurol 2004;56(suppl 8):S52.
15. Lin KH, Wang PJ, Fuh JL, et al. Cluster headache in Taiwanese - A clinic-based study. Cephalalgia 2004;24:631-8.
16. Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. Cephalalgia 2004;24(suppl 1):1-160.
17. Swaab DF, Hofman MA, Lucassen PJ, et al. Functional neuroanatomy and neuropathology of the human hypothalamus. Anat Embryol 1993;187:317-30.
18. Bartsch T, Levy MJ, Knight YE, et al. Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus. Pain 2005;117:30-9.
19. Matharu MS, Levy MJ, Meeran K, et al. Subcutaneous octreotide in cluster headache: randomized placebo-controlled double-blind crossover study. Ann Neurol 2004;56:488-94.
20. Bigal ME, Rapoport AM, Sheftell FD, et al. Chronic migraine is an earlier stage of transformed migraine in adults. Neurology 2005;65:1556-61.