Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Ahmad, Nauman ^a   Wang, Yigang ^a   Ali, Ailia K ^a   Ashraf, Muhammad ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Akt; Preconditioning; Sustained cardiac protection

Indexed keywords

5 HYDROXYDECANOIC ACID; LACTATE DEHYDROGENASE; PHOSPHODIESTERASE V; PROTEIN KINASE B; TADALAFIL; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISCHEMIC PRECONDITIONING; ISOLATED HEART; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOTTING, WESTERN; CARBOLINES; CARDIOTONIC AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; ONCOGENE PROTEIN V-AKT; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; VENTRICULAR FUNCTION, LEFT;

EID: 67650065305     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00169.2009     Document Type: Article

References (25)

1. ATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. Am J Physiol Heart Circ Physiol 290: H2402-H2408, 2006.
2. Boswell-Smith V, Page CP. Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease. Expert Opin Investig Drugs 15: 1105-1113, 2006.
3. Das A, Ockaili R, Salloum F, Kukreja RC. Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits. Am J Physiol Heart Circ Physiol 286: H1455-H1460, 2004.
4. Das A, Smolenski A, Lohmann SM, Kukreja RC. Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte. J Biol Chem 281: 38644-38652, 2006.
5. Gross ER, Hsu AK, Gross GJ. Opioid-induced cardioprotection occurs via glycogen synthase kinase β inhibition during reperfusion in intact rat hearts. Circ Res 94: 960-966, 2004.
6. Gross GJ. Sildenafil and endothelial dysfunction in humans. Circulation 111: 721-723, 2005.
7. Guazzi M, Samaja M. The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development. Curr Med Chem 14: 2181-2191, 2007.
8. Han H, Wang H, Long H, Nattel S, Wang Z. Oxidative preconditioning and apoptosis in L-cells. Roles of protein kinase B and mitogen-activated protein kinases. J Biol Chem 276: 26357-26364, 2001.
9. Kass DA, Champion HC, Beavo JA. Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circ Res 101: 1084-1095, 2007.
10. Kukreja RC, Ockaili R, Salloum F, Yin C, Hawkins J, Das A, Xi L. Cardioprotection with phosphodiesterase-5 inhibition - a novel preconditioning strategy. J Mol Cell Cardiol 36: 165-173, 2004.
11. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104: 330-335, 2001.
12. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.
13. Niagara MI, Haider HKh, Jiang S, Ashraf M. Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart. Circ Res 100: 447-449, 2007.
14. ATP channels in rabbits. Am J Physiol Heart Circ Physiol 283: H1263-H1269, 2002.
15. Peart JN, Gross GJ. Morphine-tolerant mice exhibit a profound and persistent cardioprotective phenotype. Circulation 109: 1219-1222, 2004.
16. Raphael J, Abedat S, Rivo J, Meir K, Beeri R, Pugatsch T, Zuo Z, Gozal Y. Volatile anesthetic preconditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via Akt signaling and modulation of Bcl-2 family proteins. J Pharmacol Exp Ther 318: 186-194, 2006.
17. Salloum F, Yin C, Xi L, Kukreja RC. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ Res 92: 595-597, 2003.
18. Senzaki H, Smith CJ, Juang GJ, Isoda T, Ohler A, Paolocci N, Tomaselli GF, Hare JM, Kass DA. Cardiac phosphodiesterase 5 (cGMP specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J 15: 1718-1726, 2001.
19. Sesti C, Florio V, Johnson EG, Kloner RA. The phosphodiesterase-5 inhibitor tadalafil reduces myocardial infarct size. Int J Impot Res 19: 55-61, 2007.
20. Solenkova NV, Solodushko V, Cohen MV, Downey JM. Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol 290: H441-H449, 2006.
21. Wang L, Gang Zhang Z, Lan Zhang R, Chopp M. Activation of the PI3-K/AKT pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone. J Cereb Blood Flow Metab 25: 1150-1158, 2005.
22. Wang Y, Ahmad N, Kudo M, Ashraf M. Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning. Am J Physiol Heart Circ Physiol 287: H1125-H1131, 2004.
23. Wang Y, Ahmad N, Wang B, Ashraf M. Chronic preconditioning: a novel approach for cardiac protection. Am J Physiol Heart Circ Physiol 292: H2300-H2305, 2007.
24. ATP channel openers produce acute and delayed cardioprotection. Vascul Pharmacol 42: 253-264, 2005.
25. Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, Ronson RS, Guyton RA, Vinten-Johansen J. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res 45: 651-660, 2000.