l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury

Toxicology Letters

Volumn 189, Issue 3, 2009, Pages 200-205

  Piacenza, Francesco ^a   Malavolta, Marco ^b   Cipriano, Catia ^b   Costarelli, Laura ^b   Giacconi, Robertina ^b   Muti, Elisa ^b   Tesei, Silvia ^b   Pierpaoli, Sara ^b   Basso, Andrea ^b   Bracci, Massimo ^a   Bonacucina, Viviana ^a   Santarelli, Lory ^a   Mocchegiani, Eugenio ^b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b INRCA   (Italy)

Author keywords

Inorganic mercury; Kidney; l Arginine; Metallothioneins; Nitric oxide synthase; Zinc

Indexed keywords

ARGININE; COPPER; CREATININE; INDUCIBLE NITRIC OXIDE SYNTHASE; MERCURY CHLORIDE; MESSENGER RNA; METALLOTHIONEIN; NITRIC OXIDE SYNTHASE; PROTEIN; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; KIDNEY INJURY; KIDNEY PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; TISSUE DISTRIBUTION; URINARY EXCRETION; ZINC METABOLISM;

ANIMALS; ARGININE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; CREATININE; KIDNEY; MALE; MASS SPECTROMETRY; MERCURIC CHLORIDE; MERCURY; MERCURY POISONING; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN BINDING; PROTEINURIA; RNA, MESSENGER; TISSUE DISTRIBUTION;

MUS;

EID: 67650064597     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.05.021     Document Type: Article

References (40)

1. Barregard L. Exposure to inorganic mercury: from dental amalgam to artisanal gold mining. Environ. Res. 107 (2008) 4-5
2. Baum C.R. Treatment of mercury intoxication. Curr. Opin. Pediatr. 11 (1999) 265-268
3. Bracci M., Tomasetti M., Malavolta M., Bonacucina V., Mocchegiani E., and Santarelli L. l-Arginine reduces mercury accumulation in thymus of mercury-exposed mice: role of nitric oxide synthase activity and metallothioneins. Ind. Health 46 (2008) 567-574
4. Brandford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
5. Carmignani M., and Boscolo P. Cardiovascular homeostasis in rats chronically exposed to mercuric chloride. Arch. Toxicol. Suppl. 7 (1984) 383-388
6. Chatterjee P.K., Patel N.S., Kvale E.O., Cuzzocrea S., Brown P.A., Stewart K.N., Mota-Filipe H., and Thiemermann C. Inhibition of inducible nitric oxide synthase reduces renal ischemia-reperfusion injury. Kidney Int. 61 (2002) 862-871
7. Clarkson T.W., and Magos L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 37 (2007) 537-549
8. Clifton J.C. Mercury exposure and public health. Pediatr. Clin. North. Am. 54 (2007) 237-269
9. Fabris N., and Mocchegiani E. Arginine-containing compounds and thymic endocrine activity. Thymus 19 (1992) 21-30
10. Funk A.E., Day F.A., and Brady F.O. Displacement of zinc and copper from copper-induced metallothionein by cadmium and by mercury: in vivo and ex vivo studies. Comp. Biochem. Physiol. C 86 (1987) 1-6
11. Ganote C.E., Reimer K.A., and Jennings R.B. Acute mercuric chloride nephrotoxicity: an electron microscopic and metabolic study. Lab. Invest. 31 (1974) 633-647
12. Griem P., Scholz E., Turfeld M., Zander D., Wiesner U., Dunemann L., and Gleichmann E. Strain differences in tissue concentrations of mercury in inbred mice treated with mercuric chloride. Toxicol. Appl. Pharmacol. 144 (1997) 163-170
13. Malavolta M., Piacenza F., Costarelli L., Giacconi R., Muti E., Cipriano C., Tesei S., Spezia S., and Mocchegiani E. Combining UHR-SEC-HPLC-ICP-MS with flow cytometry to quantify metallothioneins and to study zinc homeostasis in human PBMC. J. Anal. Atom. Spectrom. 22 (2007) 1193-1198
14. Mittal C.K., Harrell W.B., and Mehta C.S. Interaction of heavy metal toxicants with brain constitutive nitric oxide synthase. Mol. Cell. Biochem. 149-150 (1995) 263-265
15. Mocchegiani E., Muzzioli M., Santarelli L., and Fabris N. Restoring effect of oral supplementation of zinc and arginine on thymic endocrine activity and peripheral immune functions in aged mice. Arch. Gerontol. Geriatr. Suppl. 3 (1992) 267-276
16. Mocchegiani E., Nistico G., Santarelli L., and Fabris N. Effect of l-arginine on thymic function. Possible role of Larginine: nitric oxide (no) pathway. Arch. Gerontol. Geriatr. 1 (1994) 163-170
17. Mocchegiani E., Muzzioli M., and Giacconi R. Zinc and immunoresistance to infection in aging: new biological tools. Trends Pharmacol. Sci. 21 (2000) 205-208
18. Mocchegiani E., Santarelli L., Costarelli L., Cipriano C., Muti E., Giacconi R., and Malavolta M. Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine. Ageing Res. Rev. 5 (2006) 281-309
19. Orloff K.G., Ulirsch G., Wilder L., Block A., Fagliano J., and Pasqualo J. Human exposure to elemental mercury in a contaminated residential building. Arch. Environ. Health 52 (1997) 169-172
20. Peters H., Border W.A., and Noble N.A. From rats to man: a perspective on dietary l-arginine supplementation in human renal disease. Nephrol. Dial. Transplant. 14 (1999) 1640-1650
21. Rao M.R., Olinde K.D., and Markov A.K. In vitro induction of nitric oxide by fructose-1,6-diphosphate in the cardiovascular system of rats. Mol. Cell Biochem. 185 (1998) 171-175
22. Reckelhoff J.F., Kellum Jr. J.A., Racusen L.C., and Hildebrandt D.A. Long-term dietary supplementation with l-arginine prevents age-related reduction in renal function. Am. J. Physiol. 272 (1997) 1768-1774
23. Reus I.S., Bando I., Andrés D., and Cascales M. Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats. J. Biochem. Mol. Toxicol. 17 (2003) 161-168
24. Reyes A.A., Karl I.E., Kissane J., and Klahr S. l-Arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J. Am. Soc. Nephrol. 4 (1993) 1039-1045
25. Reyes A.A., Purkerson M.L., Karl I., and Klahr S. Dietary supplementation with l-arginine ameliorates the progression of renal disease in rats with subtotal nephrectomy. Am. J. Kidney Dis. 20 (1992) 168-176
26. Risher J.F., and De Rosa C.T. Inorganic: the other mercury. J. Environ. Health 70 (2007) 9-16
27. Risher J.F., and Amler S.N. Mercury exposure: evaluation and intervention the inappropriate use of chelating agents in the diagnosis and treatment of putative mercury poisoning. Neurotoxicology 26 (2005) 691-699
28. Rodríguez-Martín E., Casarejos M.J., Canals S., de Bernardo S., and Mena M.A. Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures. Neuropharmacology 43 (2002) 877-888
29. Sällsten G., and Barregård L. Urinary excretion of mercury, copper and zinc in subjects exposed to mercury vapour. Biometals 10 (1997) 357-361
30. Santarelli L., Bracci M., and Mocchegiani E. In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-γ, IL-6): Role of the nitric oxide-l-arginine pathway. Int. Immunopharmacol. 6 (2006) 376-389
31. Sasso F.S., Ferraluolo R., Garetano G., Gursky E., Fagliano J., Pasqualo J., Salkie R., and Rotola J. Mercury exposure among residents of a building formerly used for industrial purposes-New Jersey. Morbid. Mortal. Week. Rep. 45 (1996) 422-424
32. Satarug S., Baker J.R., Reilly P.E., Esumi H., and Moore M.R. Evidence for a synergistic interaction between cadmium and endotoxin toxicity and for nitric oxide and cadmium displacement of metals in the kidney. Nitric Oxide 4 (2000) 431-440
33. Schäfer S.C., Wallerath T., Closs E.I., Schmidt C., Schwarz P.M., Förstermann U., and Lehr H.A. Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H436-H444
34. Society of Toxicology. Guiding principles in the use of animals in toxicology. Adopted by the Society of Toxicology in July 1989. Toxicol. Appl. Pharmacol. 178 (2002) 4 pp.
35. Stacchiotti A., Ricci F., Rezzani R., Li Volti G., Borsani E., Lavazza A., Bianchi R., and Rodella L.F. Tubular stress proteins and nitric oxide synthase expression in rat kidney exposed to mercuric chloride and melatonin. J. Histochem. Cytochem. 54 (2006) 1149-1157
36. Tian L., and Lawrence D.A. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel, and cobalt utilize different mechanisms. Toxicol. Appl. Pharmacol. 141 (1996) 540-547
37. Weinberg J.B., Granger D.L., Pisetsky D.S., Seldin M.F., Misukonis M.A., Mason S.N., Pippen A.M., Ruiz P., Wood E.R., and Gilkeson G.S. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-l-arginine. J. Exp. Med. 179 (1994) 651-660
38. Yanagisawa H., Nodera M., and Wada O. Inducible nitric oxide synthase expression in mercury chloride-induced acute tubular necrosis. Ind. Health 36 (1998) 324-330
39. Yeates K.O., and Mortensen M.E. Acute and chronic neuropsychological consequences of mercury vapor poisoning in two early adolescents. J. Clin. Exp. Neuropsychol. 16 (1994) 209-222
40. Zangger K., Oz G., Haslinger E., Kunert O., and Armitage I.M. Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: potential role at inflammatory sites. FASEB J. 15 (2001) 1303-1305