An improved synthesis of (4-{4-hydroxy-3-isopropyl-5-[(4-nitrophenyl) ethynyl] benzyl}-3,5-dimethylphenoxy)acetic acid (NH-3)

Synthesis

Volumn , Issue 9, 2009, Pages 1428-1430

  Gopinathan, Madathil B ^a   Rehder, Kenneth S ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

1 iodo 4 nitrobenzene; Coupling; Hydrolysis; Palladium catalysis; Sonogashira coupling

Indexed keywords

1-IODO-4-NITROBENZENE; CATALYZED COUPLING; ESTER GROUPS; ETHYNYL; HIGH YIELD; METHOXYMETHYL; PALLADIUM CATALYSIS; QUANTITATIVE YIELDS; SONOGASHIRA COUPLING; TRIMETHYLSILYL;

ACETIC ACID; ACETYLENE; ACIDS; CATALYSIS; ESTERS; HYDROLYSIS; LIGHTING; NITROBENZENE; PALLADIUM; PH EFFECTS;

ORGANOMETALLICS;

[4 [3 ISOPROPYL 4 (METHOXYMETHOXY) 5 [(4 NITROPHENYL)ETHYNYL]BENZYL] 3,5 DIMETHYLPHENOXY)ACETIC ACID; [4 [4 HYDROXY 3 ISOPROPYL 5 [(4 NITROPHENYL)ETHYNYL]BENZYL] 3,5 DIMETHYLPHENOXY]ACETIC ACID; ACETIC ACID DERIVATIVE; METHYL [4 [3 ISOPROPYL 4 (METHOXYMETHOXY) 5 [(4 NITROPHENYL)ETHYNYL]BENZYL] 3,5 DIMETHYLPHENOXY]ACETATE; METHYL [4 [3 ISOPROPYL 4 (METHOXYMETHOXY) 5 [(TRIMETHYLSILYL)ETHYNYL]BENZYL] 3,5 DIMETHYLPHENOXY]ACETATE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SONOGASHIRA REACTION; SYNTHESIS; TEMPERATURE MEASUREMENT;

EID: 67650064567     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0028-1088041     Document Type: Article

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