Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer

Archiv der Pharmazie

Volumn 342, Issue 7, 2009, Pages 420-427

  Krasavin, Mikhail ^a   Karapetian, Ruben ^a   Konstantinov, Igor ^a   Gezentsvey, Yuri ^a   Bukhryakov, Konstantin ^a   Godovykh, Elena ^a   Soldatkina, Olga ^a   Lavrovsky, Yan ^a   Sosnov, Andrei V ^a   Gakh, Andrei A ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

Antiproliferative activity; Cytotoxicity; Drug likeness; Prostate cancer; Small molecules

Indexed keywords

3 (2 FURYL) N [5 (4 METHOXYBENZYL) 1,3 THIAZOL 2 YL]ACRYLAMIDE; 4 (4 BROMOPHENOXY) N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL]BUTANAMIDE; 4 (4 CHLOROPHENOXY) N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL]BUTANAMIDE; 5 (4 ISOPROPYLBENZYL) 1,3 THIAZOL 2 AMINE; 5 [2 CHLORO 5 (TRIFLUOROMETHYL)BENZYL] 1,3 THIAZOL 2 AMINE; 5 [4 CHLORO 3 (TRIFLUOROMETHYL)BENZYL] 1,3 THIAZOL 2 AMINE; ANTINEOPLASTIC AGENT; DIGITONIN; N (5 BENZYL 1,3 THIAZOL 2 YL)CHROMANE 3 CARBOXAMIDE; N [5 (4 CHLOROBENZYL) 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 (4 ETHYLBENZYL) 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 3 (2 FURYL)ACRYLAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 3 (3 METHYLPHENYL)ACRYLAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 3 (5 METHYL 2 FURYL)ACRYLAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 3 [5 [TRANS 2 METHYLCYCLOPROPYL] 2 FURYL]PROPANAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 3,4 DIMETHOXYBENZAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL] 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE 3 CARBOXAMIDE; N [5 (4 FLUOROBENZYL) 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 (4 ISOPROPYLBENZYL) 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 (4 METHOXYBENZYL) 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 (4 METHYLBENZYL) 1,3 THIAZOL 2 YL]CHROMANE CARBOXAMIDE; N [5 [2 CHLORO 5 (TRIFLUOROMETHYL)BENZYL] 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; N [5 [4 CHLORO 3 (TRIFLUOROMETHYL)BENZYL] 1,3 THIAZOL 2 YL]CHROMANE 3 CARBOXAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 67650046130     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800201     Document Type: Article

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