메뉴 건너뛰기




Volumn 47, Issue 2, 2009, Pages 14-18

Thrombolytic therapy with alteplase for ischaemic stroke
[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALTEPLASE; DESMOTEPLASE; PLACEBO; STREPTOKINASE; UROKINASE; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

EID: 67650039772     PISSN: 00126543     EISSN: None     Source Type: Journal    
DOI: 10.1136/dtb.2009.01.0001     Document Type: Article
Times cited : (2)

References (42)
  • 1
    • 77749281347 scopus 로고    scopus 로고
    • DH/ Vascular Programme/ Stroke. A new ambition for stroke. A consultation on a national strategy. London: Department of Health, 2007.
    • DH/ Vascular Programme/ Stroke. A new ambition for stroke. A consultation on a national strategy. London: Department of Health, 2007.
  • 3
    • 77749266334 scopus 로고    scopus 로고
    • Division of Health and Social Care Research, King's College London.Economic burden of stroke in England [online]. Available: http://www.nao.org.uk/system-pages/idoc.ashx?docid=11ed54b8-babf-4c0e-aefc- 2a09b55de4ae&version=-1 [Accessed 23 January 2009].
    • Division of Health and Social Care Research, King's College London.Economic burden of stroke in England [online]. Available: http://www.nao.org.uk/system-pages/idoc.ashx?docid=11ed54b8-babf-4c0e-aefc- 2a09b55de4ae&version=-1 [Accessed 23 January 2009].
  • 4
    • 77749238092 scopus 로고    scopus 로고
    • Hudson J et al. Joining forces to deliver improved stroke care. London: The National Audit Office 2007.
    • Hudson J et al. Joining forces to deliver improved stroke care. London: The National Audit Office 2007.
  • 5
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581-7.
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 6
    • 38949091419 scopus 로고    scopus 로고
    • Acute ischaemic stroke in patients aged 80 years and older
    • Poppe AY, Hill MD. Acute ischaemic stroke in patients aged 80 years and older. Drugs Aging 2008; 25: 95-103.
    • (2008) Drugs Aging , vol.25 , pp. 95-103
    • Poppe, A.Y.1    Hill, M.D.2
  • 7
    • 77749281342 scopus 로고    scopus 로고
    • A practical approach to the management of stroke and transient ischaemic attack
    • Third Edition. Blackwell Publishing: Oxford
    • Warlow C et al. A practical approach to the management of stroke and transient ischaemic attack. Stroke: practical management Third Edition. Blackwell Publishing: Oxford, 2008.
    • (2008) Stroke: Practical management
    • Warlow, C.1
  • 8
    • 0037383268 scopus 로고    scopus 로고
    • Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association
    • Adams HP et al. Guidelines for the early management of patients with ischemic stroke: a scientific statement from the Stroke Council of the American Stroke Association. Stroke 2003; 34: 1056-83.
    • (2003) Stroke , vol.34 , pp. 1056-1083
    • Adams, H.P.1
  • 9
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • Hacke W et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359: 1317-29.
    • (2008) N Engl J Med , vol.359 , pp. 1317-1329
    • Hacke, W.1
  • 10
    • 0034161354 scopus 로고    scopus 로고
    • Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) study
    • Albers GW et al. Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study. JAMA 2000; 283: 1145-50.
    • (2000) JAMA , vol.283 , pp. 1145-1150
    • Albers, G.W.1
  • 11
    • 33846347159 scopus 로고    scopus 로고
    • Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): An observational study
    • Wahlgren N et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007; 369: 275-82.
    • (2007) Lancet , vol.369 , pp. 275-282
    • Wahlgren, N.1
  • 12
    • 84988905804 scopus 로고    scopus 로고
    • Wardlaw JM et al. Thrombolysis for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD000213. DOI: 10.1002/14651858. CD000213 [Date of most recent substantive amendment 14 March 2003].
    • Wardlaw JM et al. Thrombolysis for acute ischaemic stroke. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD000213. DOI: 10.1002/14651858. CD000213 [Date of most recent substantive amendment 14 March 2003].
  • 13
    • 70450195021 scopus 로고
    • Functional evaluation: The Barthel Index
    • Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J 1965; 14: 56-61.
    • (1965) Md State Med J , vol.14 , pp. 56-61
    • Mahoney, F.I.1    Barthel, D.W.2
  • 14
    • 0016475167 scopus 로고
    • Assessment of outcome after severe brain damage: A practical scale
    • Jennett B, Bond M. Assessment of outcome after severe brain damage: a practical scale. Lancet 1975; 1: 480-4.
    • (1975) Lancet , vol.1 , pp. 480-484
    • Jennett, B.1    Bond, M.2
  • 15
    • 33744973270 scopus 로고    scopus 로고
    • Clinical interpretation and use of stroke scales
    • Kasner SE. Clinical interpretation and use of stroke scales. Lancet Neurol 2006; 5: 603-12.
    • (2006) Lancet Neurol , vol.5 , pp. 603-612
    • Kasner, S.E.1
  • 16
    • 33749037692 scopus 로고    scopus 로고
    • Early MRI and outcomes of untreated patients with mild or improving ischemic stroke
    • Rajajee V et al. Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology 2006; 67: 980-4.
    • (2006) Neurology , vol.67 , pp. 980-984
    • Rajajee, V.1
  • 17
    • 33644874026 scopus 로고    scopus 로고
    • Time is brain-quantified
    • Saver JL. Time is brain-quantified. Stroke 2006; 37: 263-6.
    • (2006) Stroke , vol.37 , pp. 263-266
    • Saver, J.L.1
  • 18
    • 26844498114 scopus 로고    scopus 로고
    • The Recognition of Stroke in the Emergency Room (ROSIER) scale: Development and validation of a stroke recognition instrument
    • Nor AM et al. The Recognition of Stroke in the Emergency Room (ROSIER) scale: development and validation of a stroke recognition instrument. Lancet Neurol 2005; 4: 727-34.
    • (2005) Lancet Neurol , vol.4 , pp. 727-734
    • Nor, A.M.1
  • 19
    • 2542561906 scopus 로고    scopus 로고
    • Intra-arterial thrombolysis in acute ischemic stroke: A review of pharmacologic approaches
    • Pettersen JA et al. Intra-arterial thrombolysis in acute ischemic stroke: a review of pharmacologic approaches. Expert Rev Cardiovasc Ther 2004; 2: 285-99.
    • (2004) Expert Rev Cardiovasc Ther , vol.2 , pp. 285-299
    • Pettersen, J.A.1
  • 20
    • 49449090502 scopus 로고    scopus 로고
    • Thrombolysis for acute ischaemic stroke: A new challenge for emergency medicine
    • Kendall J. Thrombolysis for acute ischaemic stroke: a new challenge for emergency medicine. Emerg Med J 2008; 25: 471-5.
    • (2008) Emerg Med J , vol.25 , pp. 471-475
    • Kendall, J.1
  • 21
    • 77749238089 scopus 로고    scopus 로고
    • and Drug Administration Center for Drug Evaluation and Research, online, Available:, Accessed 23 January 2009
    • US Food and Drug Administration Center for Drug Evaluation and Research, 1996. Alteplase. Summary basis of approval [online]. Available: http://www.fda.gov/CDER/biologics/sba/altegen0618965.pdf [Accessed 23 January 2009].
    • (1996) Alteplase. Summary basis of approval
    • Food, U.S.1
  • 22
    • 4944222683 scopus 로고    scopus 로고
    • Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial
    • Ingall TJ et al. Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial. Stroke 2004; 35: 2418-24.
    • (2004) Stroke , vol.35 , pp. 2418-2424
    • Ingall, T.J.1
  • 23
    • 0034120507 scopus 로고    scopus 로고
    • The rt-PA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): Results of a double-blind, placebo-controlled, multicenter study
    • Clark WM et al. The rt-PA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Stroke 2000; 31: 811-6.
    • (2000) Stroke , vol.31 , pp. 811-816
    • Clark, W.M.1
  • 24
    • 0033485522 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset: The ATLANTIS study: A randomized controlled trial
    • Clark WM et al. Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset: the ATLANTIS study: A randomized controlled trial. JAMA 1999; 282: 2019-26.
    • (1999) JAMA , vol.282 , pp. 2019-2026
    • Clark, W.M.1
  • 25
    • 33846605563 scopus 로고    scopus 로고
    • Confirmation of tPA treatment effect by baseline severity-adjusted end point reanalysis of the NINDS-tPA stroke trials
    • Saver JL, Yafeh B. Confirmation of tPA treatment effect by baseline severity-adjusted end point reanalysis of the NINDS-tPA stroke trials. Stroke 2007; 38: 414-6.
    • (2007) Stroke , vol.38 , pp. 414-416
    • Saver, J.L.1    Yafeh, B.2
  • 26
    • 0033542395 scopus 로고    scopus 로고
    • Effects of tissue plasminogen activator for acute ischemic stroke at one year
    • Kwiatkowski TG et al. Effects of tissue plasminogen activator for acute ischemic stroke at one year. N Engl J Med 1999; 340: 1781-7.
    • (1999) N Engl J Med , vol.340 , pp. 1781-1787
    • Kwiatkowski, T.G.1
  • 27
    • 1542315556 scopus 로고    scopus 로고
    • ECASS, and NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    • The ATLANTIS
    • The ATLANTIS, ECASS, and NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004; 363: 768-74.
    • (2004) Lancet , vol.363 , pp. 768-774
  • 28
    • 77749253539 scopus 로고    scopus 로고
    • Summary of product characteristics, EU. Boehringer Ingelheim Limited, April
    • Actilyse. Summary of product characteristics, EU. Boehringer Ingelheim Limited, April 2004.
    • (2004) Actilyse
  • 29
    • 40349090522 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence, online, Available:, Accessed 23 January 2009
    • National Institute for Health and Clinical Excellence, 2007. Alteplase for the treatment of acute ischaemic stroke. NICE technology appraisal guidance 122 [online]. Available: http://http://www.nice.org.uk/nicemedia/pdf/ TA122guidance.pdf guidance.pdf [Accessed 23 January 2009].
    • (2007) Alteplase for the treatment of acute ischaemic stroke. NICE technology appraisal guidance 122
  • 30
    • 77749266332 scopus 로고    scopus 로고
    • online, Available:, Accessed 23 January 2009
    • Scottish Medicines Consortium, 2004. Alteplase (Actilyse). No. 87/04 [online]. Available: http://www.scottishmedicines.org.uk/smc/files/ Alteplase.pdf [Accessed 23 January 2009].
    • (2004) Alteplase (Actilyse). No. 87/04
  • 31
    • 10744221456 scopus 로고    scopus 로고
    • European Stroke Initiative recommendations for stroke management - update 2003
    • The European Stroke Initiative Executive Committee, the EUSI Writing Committee
    • The European Stroke Initiative Executive Committee, the EUSI Writing Committee. European Stroke Initiative recommendations for stroke management - update 2003. Cerebrovasc Dis 2003; 16: 311-37.
    • (2003) Cerebrovasc Dis , vol.16 , pp. 311-337
  • 32
    • 34247844511 scopus 로고    scopus 로고
    • Guidelines for the early management of adults with ischemic stroke: A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups
    • Adams HP et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups. Stroke 2007; 38: 1655-711.
    • (2007) Stroke , vol.38 , pp. 1655-1711
    • Adams, H.P.1
  • 34
    • 19744368662 scopus 로고    scopus 로고
    • Thrombolysis for acute ischemic stroke: Results of the Canadian Alteplase for Stroke Effectiveness Study
    • Hill MD, Buchan AM. Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ 2005; 172: 1307-12.
    • (2005) CMAJ , vol.172 , pp. 1307-1312
    • Hill, M.D.1    Buchan, A.M.2
  • 35
    • 77749281340 scopus 로고    scopus 로고
    • Royal College of Physicians of London 2008. National Sentinel Stroke Audit Phase 1 Organisational audit 2008. Report for England, Wales and Northern Ireland [online]. Available: http://www.rcplondon.ac.uk/Clinical-Standards/ ceeu/Current-work/Documents/Public%organisation%20report2008.pdf [Accessed 23 January 2009].
    • Royal College of Physicians of London 2008. National Sentinel Stroke Audit Phase 1 Organisational audit 2008. Report for England, Wales and Northern Ireland [online]. Available: http://www.rcplondon.ac.uk/Clinical-Standards/ ceeu/Current-work/Documents/Public%organisation%20report2008.pdf [Accessed 23 January 2009].
  • 36
    • 40949161352 scopus 로고    scopus 로고
    • Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial
    • Davis SM et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 2008; 7: 299-309.
    • (2008) Lancet Neurol , vol.7 , pp. 299-309
    • Davis, S.M.1
  • 37
    • 24044498688 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activator for minor strokes: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience
    • The National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group
    • The National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group. Recombinant tissue plasminogen activator for minor strokes: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience. Ann Emerg Med 2005; 46: 243-52.
    • (2005) Ann Emerg Med , vol.46 , pp. 243-252
  • 38
    • 47349115423 scopus 로고    scopus 로고
    • Sandercock P et al. The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials 2008; 9: 37 doi: 10.1186/1745-6215-9-37.
    • Sandercock P et al. The third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials 2008; 9: 37 doi: 10.1186/1745-6215-9-37.
  • 39
    • 16844376360 scopus 로고    scopus 로고
    • Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update. A scientific statement from the Stroke Council of the American Heart Association/American Stroke Association
    • Adams H et al. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update. A scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke 2005; 36: 916-23.
    • (2005) Stroke , vol.36 , pp. 916-923
    • Adams, H.1
  • 40
    • 53249095475 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): An observational study
    • Wahlgren N et al. Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet 2008; 372: 1303-9.
    • (2008) Lancet , vol.372 , pp. 1303-1309
    • Wahlgren, N.1
  • 41
    • 33646687051 scopus 로고    scopus 로고
    • Good outcomes in ischemic stroke patients treated with intravenous thrombolysis despite regressing neurological symptoms
    • Baumann CR et al. Good outcomes in ischemic stroke patients treated with intravenous thrombolysis despite regressing neurological symptoms. Stroke 2006; 37: 1332-3.
    • (2006) Stroke , vol.37 , pp. 1332-1333
    • Baumann, C.R.1
  • 42
    • 34548201773 scopus 로고    scopus 로고
    • Intravenous alteplase for stroke. Beyond the guidelines and in particular clinical situations
    • De Keyser J et al. Intravenous alteplase for stroke. Beyond the guidelines and in particular clinical situations. Stroke 2007; 38: 2612-8.
    • (2007) Stroke , vol.38 , pp. 2612-2618
    • De Keyser, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.