Role of coupled gating between cardiac ryanodine receptors in the genesis of triggered arrhythmias

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Chen, Wei ^a   Wasserstrom, J Andrew ^b   Shiferaw, Y ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Arrhythmia; Calcium; Modeling

Indexed keywords

RYANODINE RECEPTOR;

ARRHYTHMOGENESIS; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHANNEL GATING; HEART ARRHYTHMIA; MATHEMATICAL MODEL; MEMBRANE POTENTIAL; PRIORITY JOURNAL;

ALGORITHMS; ARRHYTHMIAS, CARDIAC; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; ELECTROPHYSIOLOGY; ION CHANNEL GATING; MODELS, STATISTICAL; MYOCARDIUM; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SUBCELLULAR FRACTIONS;

EID: 67650032880     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00098.2009     Document Type: Article

References (23)

1. Bers DM. Cardiac excitation-contraction coupling. Nature 415: 198-205, 2002.
2. Gilmour RF Jr, Moise NS. Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs. J Am Coll Cardiol 27: 1526-1533, 1996.
3. Janse MJ. Electrophysiological changes in heart failure and their relationship to arrhythmogenesis. Cardiovasc Res 61: 208-217, 2004.
4. 2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Circ Res 97: 1173-1181, 2005.
5. 2+ release (SOICR). Proc Natl Acad Sci USA 101: 13062-13067, 2004.
6. Langer GA, Peskoff A. Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell. Biophys J 70: 1169-1182, 1996.
7. 2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest 118: 2230-2245, 2008.
8. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci USA 103: 7906-7910, 2006.
9. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109: 3208-3214, 2004.
10. Liu N, Colombi B, Memmi M, Zissimopoulos S, Rizzi N, Negri S, Imbriani M, Napolitano C, Lai FA, Priori SG. Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res 99: 292-298, 2006.
11. Liu N, Priori SG. Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin. Cardiovasc Res 77: 293-301, 2008.
12. Liu N, Ruan Y, Priori SG. Catecholaminergic polymorphic ventricular tachycardia. Prog Cardiovasc Dis 51: 23-30, 2008.
13. Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J 94: 392-410, 2008.
14. Marx SO, Gaburjakova J, Gaburjakova M, Henrikson C, Ondrias K, Marks AR. Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res 88: 1151-1158, 2001.
15. Moise NS, Gilmour RF Jr, Riccio ML. An animal model of spontaneous arrhythmic death. J Cardiovasc Electrophysiol 8: 98-103, 1997.
16. Pogwizd SM, McKenzie JP, Cain ME. Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation 98: 2404-2414, 1998.
17. Restrepo JG, Weiss JN, Karma A. Calsequestrin-mediated mechanism for cellular calcium transient alternans. Biophys J 95: 3767-3789, 2008.
18. 2+ signal transduction. Trends Pharmacol Sci 24: 167-171, 2003.
19. Stern MD, Song LS, Cheng H, Sham JS, Yang HT, Boheler KR, Rios E. Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors. J Gen Physiol 113: 469-489, 1999.
20. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 113: 829-840, 2003.
21. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu Rev Physiol 67: 69-98, 2005.
22. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science 304: 292-296, 2004.
23. Wit AL, Rosen MR. Pathophysiologic mechanisms of cardiac arrhythmias. Am Heart J 106: 798-811, 1983.