Cellular immune response to hepatitis C virus (HCV) in nonviremic blood donors with indeterminate anti-HCV reactivity

Transfusion

Volumn 49, Issue 7, 2009, Pages 1306-1313

  Roggendorf, Michael ^a   Hitziger, Tobias ^b   Schmidt, Michael ^b   Schottstedt, Volkmar ^b   Hennig, Holger ^b   Schumann, Alexandra ^b   Ross, Stefan ^b   Lu, Mengji ^b   Seifried, Erhard ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; VIRUS ANTIBODY; VIRUS PROTEIN;

ANTIBODY RESPONSE; ANTIGEN ANTIBODY REACTION; ARTICLE; BLOOD DONOR; CELL PROLIFERATION; CELLULAR IMMUNITY; CORRELATION ANALYSIS; COUNSELING; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; HEPATITIS C VIRUS; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNOBLOTTING; SCREENING TEST; SEROLOGY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS CORE;

BLOOD DONORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPACIVIRUS; HEPATITIS C ANTIBODIES; HEPATITIS C ANTIGENS; HUMANS; IMMUNITY, CELLULAR; VIRAL CORE PROTEINS;

EID: 67650001477     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2009.02113.x     Document Type: Article

References (20)

1. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989 244 : 359 62.
2. Abe K, Inchauspe G, Shikata T, Prince AM. Three different patterns of hepatitis C virus infection in chimpanzees. Hepatology 1992 15 : 690 5.
3. Alter HJ, Sanchez-Pescador R, Urdea MS, Wilber JC, Lagier RJ, Di Bisceglie AM, Shih JW, Neuwald PD. Evaluation of branched DNA signal amplification for the detection of hepatitis C virus RNA. J Viral Hepat 1995 2 : 121 32.
4. Beach MJ, Meeks EL, Mimms LT, Vallari D, DuCharme L, Spelbring J, Taskar S, Schleicher JB, Krawczynski K, Bradley DW. Temporal relationships of hepatitis C virus RNA and antibody responses following experimental infection of chimpanzees. J Med Virol 1992 36 : 226 37.
5. Pawlotsky JM. Diagnostic tests for hepatitis C. J Hepatol 1999 31 (Suppl 1 71 9.
6. Hoofnagle JH. Course and outcome of hepatitis C. Hepatology 2002 36 : S21 9.
7. Takaki A, Wiese M, Maertens G, Depla E, Seifert U, Liebetrau A, Miller JL, Manns MP, Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000 6 : 578 82.
8. Zibert A, Meisel H, Kraas W, Schulz A, Jung G, Roggendorf M. Early antibody response against hypervariable region 1 is associated with acute self-limiting infections of hepatitis C virus. Hepatology 1997 25 : 1245 9.
9. Dittmann S, Roggendorf M, Dürkop J, Wiese M, Lorbeer B, Deinhardt F. Long-term persistence of hepatitis C virus antibodies in a single source outbreak. J Hepatol 1991 13 : 323 7.
10. Lemaire JM, Courouce AM, Defer C, Bouchardeau F, Coste J, Agulles O, Cantaloube JF, Barlet V, Barin F. HCV RNA in blood donors with isolated reactivities by third-generation RIBA. Transfusion 2000 40 : 867 70.
11. Semmo N, Barnes E, Taylor C, Kurtz J, Harcourt G, Smith N, Klenerman P. T-cell responses and previous exposure to hepatitis C virus in indeterminate blood donors. Lancet 2005 365 : 327 9.
12. Day CL, Lauer GM, Robbins GK, McGovern B, Wurcel AG, Gandhi RT, Chung RT, Walker BD. Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection. J Virol 2002 76 : 12584 95.
13. Diepolder HM, Zachoval R, Hoffmann RM, Wierenga EA, Santantonio T, Jung MC, Eichenlaub D, Pape GR. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995 346 : 1006 7.
14. Gerlach JT, Diepolder HM, Jung MC, Gruener NH, Schraut WW, Zachoval R, Hoffmann R, Schirren CA, Santantonio T, Pape GR. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 1999 117 : 933 41.
15. Goodell V, dela Rosa C, Slota M, MacLeod B, Disis ML. Sensitivity and specificity of tritiated thymidine incorporation and ELISPOT assays in identifying antigen specific T cell immune responses. BMC Immunol 2007 8 : 21.
16. Fuchs K, Motz M, Schreier E, Zachoval R, Deinhardt F, Roggendorf M. Characterization of nucleotide sequences from European hepatitis C virus isolates. Gene 1991 103 : 163 9.
17. Pawlotsky JM. Use and interpretation of hepatitis C virus diagnostic assays. Clin Liver Dis 2003 7 : 127 37.
18. Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol 2005 175 : 3603 13.
19. Ross RS, Viazov S, Renzing-Kohler K, Roggendorf M. Changes in the epidemiology of hepatitis C infection in Germany: shift in the predominance of hepatitis C subtypes. J Med Virol 2000 60 : 122 5.
20. Gerlach JT, Ulsenheimer A, Grüner NH, Jung MC, Schraut W, Schirren CA, Heeg M, Scholz S, Witter K, Zahn R, Vogler A, Zachoval R, Pape GR, Diepolder HM. Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins. J Virol 2005 79 : 12425 33.