Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis

Journal of Antibiotics

Volumn 62, Issue 5, 2009, Pages 271-276

  Kawasaki, Takashi ^a   Sakurai, Fumi ^a   Nagatsuka, Shun Ya ^a   Hayakawa, Yoichi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Biosynthesis gene; Prodigiosin; Roseophilin; Streptomyces griseoviridis

Indexed keywords

ANTIBIOTIC AGENT; GENE PRODUCT; GENOMIC DNA; PRODIGIOSIN; ROSEOPHILIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; GENE CLUSTER; GENE DISRUPTION; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RPH GENE CLUSTER; SOUTHERN BLOTTING; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEOVIRIDIS;

ANTI-BACTERIAL AGENTS; BLOTTING, SOUTHERN; CLONING, MOLECULAR; DNA, BACTERIAL; GENES, BACTERIAL; HETEROCYCLIC COMPOUNDS, 3-RING; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; PLASMIDS; PRODIGIOSIN; PYRROLES; STREPTOMYCES;

STREPTOMYCES COELICOLOR; STREPTOMYCES GRISEOVIRIDIS;

EID: 67649998608     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.27     Document Type: Article

References (17)

1. Rapoport, H. & Holden, K. G. The synthesis of prodigiosin. J. Am. Chem. Soc. 84, 635-642 (1962).
2. Gerber, N. N. & Stahly, P. D. Prodiginine (prodigiosin-like) pigments from Streptoverti-cillium rubrireticuli, an organism that causes pink staining of polyvinyl chloride. Appl. Microbiol. 30, 807-810 (1975).
3. Tsao, S-W., Rudd, B. A. M., He, X-G., Chang, C-J. & Floss, H. G. Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives. J. Antibiot. 38, 128-131 (1985).
4. Song, J-M. et al. Purification and characterization of prodigiosin produced by integrated bioreactor from Serratia sp. KH-95. J. Biotechnol. Bioeng. 101, 157-161 (2006).
5. Kawasaki, T., Sakurai, F. & Hayakawa, Y. A prodigiosin from the roseophilin producer Streptomyces griseoviridis. J. Nat. Prod. 71, 1265-1267 (2008).
6. Hayakawa, Y., Kawakami, K., Seto, H. & Furihata, K. Structure of a new antibiotic, roseophilin. Tetrahedron Lett. 33, 2701-2704 (1992).
7. Harris, A. K. P. et al. The Serratia gene cluster encoding biosynthesis of red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation. Microbiology 150, 3547-3560 (2004).
8. Cerdeno, A. M., Bibb, M. J. & Challis, G. L. Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes. Chem. Biol. 8, 817-829 (2001).
9. Kim, D. et al. Analysis of a prodigiosin biosynthetic gene cluster from the marine bacterium Hahella chejuensis KCTC 2396. J. Microbiol. Biotechnol. 16, 1912-1918 (2006).
10. Thomas, M. G., Burkart, M. D. & Walsh, C. T. Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem. Biol. 9, 171-184 (2002).
11. 1 biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. Antimicrob. Agents Chemother. 44, 3040-3048 (2000).
12. Zhang, X. & Parry, R. J. Cloning and characterization of the pyrrolomycin biosynthesis gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065. Antimicrob. Agents Chemother. 51, 946-957 (2007).
13. Mo, S. et al. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chem. Biol. 15, 137-148 (2008).
14. Williamson, N. R. et al. Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl- pyrrol (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodiginine in biosynthesis in Streptomyces. Mol. Microbiol. 56, 971-989 (2005).
15. Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F. & Hopwood, D. A. Practical Streptomyces Genetics 405-420 (The John Innes Foundation, Norwich, 2000).
16. Sambrook, J. & Russell, D. W. Molecular Cloning: A Laboratory Manual 1.1-1.162 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 2001).
17. Meurer, G. & Hutchinson, R. Functional analysis of putative Β-ketoacyl: acyl carrier protein synthase and acyltransferase active site motifs in a type II polyketide synthase of Streptomyces glaucescens. J. Bacteriol. 177, 477-481 (1995).