Potential scorpionate antibiotics: Targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3721-3724

  Bauke Albada, H ^a   Arnusch, Christopher J ^a,b   Branderhorst, Hilbert M ^a   Verel, Anne Marie ^c   Janssen, Wouter T M ^c   Breukink, Eefjan ^b   Kruijff, Ben de ^b   Pieters, Roland J ^a   Liskamp, Rob M J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Antibiotic; Click chemistry; Dendrimer; Hydrolytic enzyme mimic; Vancomycin

Indexed keywords

ANTIBIOTIC AGENT; CYCLOPHANE DERIVATIVE; HISTIDINE; HYDROLASE; MEMBRANE LIPID; SCORPIONATE ANTIBIOTIC; TRIAZACYCLOPHANE; UNCLASSIFIED DRUG; VANCOMYCIN; VANCOMYCIN TACZYME CONJUGATE; ZINC ION; ZINC SULFATE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS; ENZYME ACTIVE SITE; LIPID HYDROLYSIS; LIPID MEMBRANE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; REACTION ANALYSIS; SOLID PHASE SYNTHESIS; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CATALYSIS; CELL MEMBRANE; DENDRIMERS; HYDROLYSIS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID; VANCOMYCIN; ZINC SULFATE;

BACTERIA (MICROORGANISMS);

EID: 67649987661     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.064     Document Type: Article

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