A one-pot method to enhance dissolution rate of low solubility drug molecules using dispersion polymerization in supercritical carbon dioxide

International Journal of Pharmaceutics

Volumn 377, Issue 1-2, 2009, Pages 60-69

  Galia, Alessandro ^a   Scialdone, Onofrio ^a   Filardo, Giuseppe ^a   Spanò, Tiziana ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Dissolution enhancement; Drug release kinetics; Polymer microspheres; Solid dispersion; Supercritical fluid

Indexed keywords

CARBON DIOXIDE; PIROXICAM; POVIDONE;

ARTICLE; DISPERSION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SUPERCRITICAL FLUID; X RAY DIFFRACTION;

CARBON DIOXIDE; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DRUG CARRIERS; DRUG COMPOUNDING; PARTICLE SIZE; PIROXICAM; POLYMERS; PYRROLIDINONES; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 67649979835     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.001     Document Type: Article

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