Fetal exposure to oral pathogens and subsequent risk for neonatal intensive care admission

Journal of Periodontology

Volumn 80, Issue 6, 2009, Pages 878-883

  Jared, Heather ^a,e   Boggess, Kim A ^b   Moss, Kevin ^a   Bose, Carl ^b   Auten, Richard ^c   Beck, James ^a   Offenbacheri, Steven ^d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e NONE   (United States)

Author keywords

Fetus; Medicine; Periodontitis; Pregnancy

Indexed keywords

EID: 67649970950     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.080642     Document Type: Article

References (22)

1. Jeffcoat MK, Geurs NC, Reddy MS, Cliver SP, Goldenberg RL, Hauth JC. Periodontal infection and preterm birth: Results of a prospective study. J Am Dent Assoc 2001;132:875-880.
2. Lieff S, Boggess KA, Murtha AP, et al. The oral conditions and pregnancy study: Periodontal status of a cohort of pregnant women. J Periodontol 2004; 75:116-126.
3. Spahr A, Klein E, Khuseyinova N, et al. Periodontal infections and coronary heart disease: Role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. Arch Intern Med 2006;166:554- 559.
4. Jansson H, Lindholm E, Lindh C, Groop L, Bratthall G. Type 2 diabetes and risk for periodontal disease: A role for dental health awareness. J Clin Periodontol 2006;33:408-414.
5. Boggess KA, Lieff S, Murtha AP, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol 2003;101:227-231.
6. Offenbacher S, Boggess KA, Murtha AP, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol 2006;107:29-36.
7. Lin D, Smith MA, Champagne C, Elter J, Beck J, Offenbacher S. Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infect Immun 2003;71:5156-5162.
8. Boggess KA, Madianos PN, Preisser JS, Moise KJ Jr., Offenbacher S. Chronic maternal and fetal Porphyromonas gingivalis exposure during pregnancy in rabbits. Am J Obstet Gynecol 2005;192:554-557.
9. Han YW, Redline RW, Li M, Yin L, Hill GB, McCormick TS. Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: Implication of oral bacteria in preterm birth. Infect Immun 2004;72:2272- 2279.
10. Bearfield C, Davenport ES, Sivapathasundaram V, Allaker RP. Possible association between amniotic fluid micro-organism infection and microflora in the mouth. BJOG 2002;109:527-533.
11. Madianos PN, Lieff S, Murtha AP, et al. Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Ann Periodontol 2001;6:175-182.
12. Boggess KA, Moss K, Madianos P, Murtha AP, Beck J, Offenbacher S. Fetal immune response to oral pathogens and risk of preterm birth. Am J Obstet Gynecol 2005;193:1121-1126.
13. Sakellari D, Socransky SS, Dibart S, Eftimiadi C, Taubman MA. Estimation of serum antibody to subgingival species using checkerboard immunoblotting. Oral Microbiol Immunol 1997;12:303-310.
14. Boggess KA, Lieff S, Murtha AP, et al. Maternal serum C-reactive protein concentration early in pregnancy and subsequent pregnancy loss. Am J Perinatol 2005; 22:299-304.
15. Boggess KA, Moss K, Murtha A, Offenbacher S, Beck JD. Antepartum vaginal bleeding, fetal exposure to oral pathogens, and risk for preterm birth at <35 weeks of gestation. Am J Obstet Gynecol 2006;194:954-960.
16. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202.
17. Yoon BH, Romero R, Shim JY, Shim SS, Kim CJ, Jun JK. C-reactive protein in umbilical cord blood: A simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. J Matern Fetal Neonatal Med 2003;14:85-90.
18. Goepfert AR, Jeffcoat MK, Andrews WW, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004;104:777-783.
19. Holst E, Goffeng AR, Andersch B. Bacterial vaginosis and vaginal microorganisms in idiopathic premature labor and association with pregnancy outcome. J Clin Microbiol 1994;32:176-186.
20. Hill GB. Preterm birth: Associations with genital and possibly oral microflora. Ann Periodontol 1998;3:222-232.
21. Conway SP, Dear PR, Smith I. Immunoglobulin profile of the preterm baby. Arch Dis Child 1985;60:208-212.
22. Mahulja-Stamenković V, Beleznay O, Stamenković M, Samardźija R, Makis J. IgG, IgM, and IgA umbilical blood concentrations in normal singleton vaginal deliveries with stinking amniotic fluid or intrapartal maternal febrility > or = 38 degrees C or duration of delivery > 12 hours. Zentralbl Gynakol 1993;115:33-35.