Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells

Journal of Neuroscience

Volumn 21, Issue 17, 2001, Pages 6666-6672

  Xu Friedman, Matthew A ^a   Harris, Kristen M ^b   Regehr, Wade G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Boston University   (United States)

Author keywords

Climbing fiber; Docked vesicles; Electron microscope; Parallel fiber; Probability of release; Serial reconstruction

Indexed keywords

ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ULTRASTRUCTURE; CEREBELLUM; CLIMBING FIBER; COMPARATIVE ANATOMY; DENSITY; ELECTRON MICROSCOPY; IMAGE RECONSTRUCTION; MITOCHONDRION; MODEL; NERVE CELL PLASTICITY; NERVE FIBER; NEUROANATOMY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

EID: 0035448875     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-17-06666.2001     Document Type: Article

References (41)

1. Depression of transmitter release at the neuromuscular junction of the frog
2. Facilitating and nonfacilitating synapses on pyramidal cells: A correlation between physiology and morphology
3. Stimulation-associated changes in frog neuromuscular junctions. A quantitative ultrastructural comparison of rapid-frozen and chemically fixed nerve terminals
4. Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum
5. Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse
6. Interplay between facilitation, depression, and residual calcium at three presynaptic terminals
7. Heterogeneity of release probability, facilitation, and depletion at central synapses
8. Interaction experiments on the responses evoked in Purkinje cells by climbing fibres
9. A quantitative study of end-plate potentials in isolated human muscle
10. Extending unbiased stereology of brain ultrastructure to three-dimensional volumes
11. Cylindrical diameters method for calibrating section thickness in serial electron microscopy
12. Dendritic spines of rat cerebellar Purkinje cells: Serial electron microscopy with reference to their biophysical characteristics
13. Variation in the number, location, and size of synaptic vesicles provides an anatomical basis for the nonuniform probability of release at hippocampal CAI synapses
14. Presynaptic origin of paired-pulse depression at climbing fibre-Purkinje cell synapses in the rat cerebellum
15. Ultrastructural correlates of naturally occurring differences in transmitter release efficacy in frog motor nerve terminals
16. Synaptic currents in cerebellar Purkinje cells
17. Synaptic vesicle populations in saccular hair cells reconstructed by electron tomography
18. Synaptic structure and transmitter release in crustacean phasic and tonic motor neurons
19. Heterogeneous, release properties of visualized individual hippocampal synapses
20. Inhibitory and excitatory synapses in crayfish stretch receptor organs studied with direct rapid-freezing and freeze-substitution
21. Simulations of synaptic transmission in 3-D reconstructions of cerebellar neuropil
22. Excitatory synaptic currents in Purkinje cells
23. Mammalian rod terminal: Architecture of a binary synapse
24. The rate of aldehyde fixation of the exocytotic machinery in cultured hippocampal synapses
25. Quantitative ultrastructural analysis of hippocampal excitatory synapses
26. Quantitative fine-structural analysis of olfactory cortical synapses
27. Morphological correlates of functionally defined synaptic vesicle populations
28. Three-dimensional structure and composition of CA3→CA1 axons in rat hippocampal slices: Implications for presynaptic connectivity and compartmentalizationcrop
29. Locus of frequencydependent depression identified with multiple-probability fluctuation analysis at rat climbing fibre-Purkinje cell synapses
30. Use of aldehyde fixatives to determine the rate of synaptic transmitter release
31. Estimates for the pool size of releasable quanta at a single central synapse and for the time required to refill the pool
32. Facilitation and depression at single central synapses
33. The synaptic vesicle cycle: A cascade of proteinprotein interactions
34. The long-lasting depression in neuromuscular transmission of frog
35. Three-dimensional relationships between hippocampal synapses and astrocytes
36. Evidence that vesicles on the synaptic ribbon of retinal bipolar neurons can be rapidly released
37. Elevated levels of glutamate at cerebellar synapses
38. Two structural adaptations for regulating transmitter release at lobster neuromuscular synapses