Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies

Analytical Chemistry

Volumn 81, Issue 13, 2009, Pages 5119-5129

  Loo, Ruey Leng ^a   Coen, Muireann ^a   Ebbels, Timothy ^a   Cloarec, Olivier ^a,b   Maibaum, Elaine ^a   Bictash, Magda ^a   Yap, Ivan ^a   Elliott, Paul ^a   Stamler, Jeremiah ^c   Nicholson, Jeremy K ^a   Holmes, Elaine ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COUPLING PATTERN; DRUG METABOLITES; EPIDEMIOLOGIC-STUDY; GLOBAL DATA; IBUPROFEN METABOLITES; INPUT PARAMETER; METABOLIC PROFILING; MONTE CARLO; NMR DATA; ORTHOGONAL PROJECTION; PREDICTION MODEL; PRESENCE/ABSENCE; RESAMPLING; SCREENING METHODS; SCREENING STRATEGY;

BIOMOLECULES; DISCRIMINANT ANALYSIS; METABOLITES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POPULATION STATISTICS; RESONANCE;

METABOLISM;

DRUG METABOLITE; IBUPROFEN; PARACETAMOL;

ADULT; ALGORITHM; ARTICLE; CHINA; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DRUG METABOLISM; EPIDEMIOLOGICAL DATA; FEMALE; HUMAN; HUMAN EXPERIMENT; JAPAN; LATENT STRUCTURE ANALYSIS; MALE; MATHEMATICAL MODEL; MONTE CARLO METHOD; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREDICTIVE VALIDITY; PROTON NUCLEAR MAGNETIC RESONANCE; SCREENING; UNITED KINGDOM; UNITED STATES; URINALYSIS; URINE;

ACETAMINOPHEN; ADULT; ANALGESICS; DISCRIMINANT ANALYSIS; EPIDEMIOLOGIC STUDIES; FEMALE; HUMANS; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; MIDDLE AGED; PREDICTIVE VALUE OF TESTS;

EID: 67649948770     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac900567e     Document Type: Article

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