Gene fusion in prostate cancer - clinical applications in diagnosis, prognosis and therapy;Eine häufige Genfusion im Prostatakarzinom Klinische Anwendungsmöglichkeiten für Diagnostik, Prognose und Therapie

Deutsche Medizinische Wochenschrift

Volumn 134, Issue , 2009, Pages 1483-1486

  Schmidt, F ^a   Scheble, V ^b   Mertz, K ^c   Perner, S ^b   Rubin, M A ^d  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c Universitatsklinik fur Dermatologie   (Austria)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

biomarker; ERG; gene fusion; prognosis; prostate cancer; TMPRSS2

Indexed keywords

ONCOPROTEIN; TMPRSS2 ETS FUSION PROTEIN, HUMAN; TMPRSS2-ETS FUSION PROTEIN, HUMAN;

GENE FUSION; GENETICS; HUMAN; MALE; PROGNOSIS; PROSTATE TUMOR; REVIEW;

GENE FUSION; HUMANS; MALE; ONCOGENE PROTEINS, FUSION; PROGNOSIS; PROSTATIC NEOPLASMS;

EID: 67649945525     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0029-1225305     Document Type: Review

References (13)

1. Attard G, Clark J, Ambroisine L et al. Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene 2008; 27: 253
2. Cerveira N, Ribeiro FR, Peixoto A et al. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia 2006; 8: 826
3. Demichelis F, Fall K, Perner S et al. TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 2007; 26: 4596
4. Fröhling S, Döhner H. Chromosomal abnormalities in cancer. N Engl J Med 2008; 359: 722
5. Hessels D, Smit FP, Verhaegh GW et al. Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer. Clin Cancer Res 2007; 13: 5103
6. Kumar-Sinha C, Tomlins SA, Chinnaiyan AM. Recurrent gene fusions in prostate cancer. Nat Rev Cancer 2008; 8: 497
7. Laxman B, Tomlins SA, Mehra R et al. Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer. Neoplasia 2006; 8: 885
8. Mehra R, Han B, Tomlins SA et al. Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases. Cancer Res 2007; 67: 7991
9. Mosquera JM, Perner S, Demichelis F et al. Morphological features of TMPRSS2-ERG gene fusion prostate cancer. J Pathol 2007; 212: 91
10. Perner S, Mosquera JM, Demichelis F et al. TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am J Surg Pathol 2007; 31: 882
11. Perner S, Schmidt FH, Hofer MD et al. Die TMPRSS2-ETS-Genfusion bein Prostatakarzinom. Der Urologe Ausg A 2007; 46: 754-760
12. Setlur SR, Mertz KD, Hoshida Y et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst 2008; 100: 815
13. Tomlins SA, Rhodes DR, Perner S et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005; 310: 644