Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus

Nephron - Experimental Nephrology

Volumn 113, Issue 2, 2009, Pages

  Katsuyama, Koichi ^a,b   Fujinaka, Hidehiko ^a,b   Yamamoto, Keiko ^a   Nameta, Masaaki ^a   Yaoita, Eishin ^a   Yoshida, Yutaka ^a   Tomizawa, Shuichi ^b   Uchiyama, Makoto ^a   Yamamoto, Tadashi ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b National Hospital Organization Niigata National Hospital   (Japan)

Author keywords

Chemokine; Glomeruli; In situ hybridization; Proteinuria; Puromycin aminonucleoside nephrosis; Western blotting

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; PUROMYCIN AMINONUCLEOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE EXPRESSION; GENE LOCATION; GLOMERULUS; GLOMERULUS FILTRATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY CORTEX; MEMBRANE; NEPHROSIS; NONHUMAN; PHYSIOLOGY; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEINURIA; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CHEMOKINE CX3CL1; FEMALE; KIDNEY GLOMERULUS; PODOCYTES; PROTEINURIA; RATS; RATS, INBRED WKY;

EID: 67649881053     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000228408     Document Type: Article

References (33)

1. Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T: Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol 2008; 84: 215-223.
2. Feng L, Chen S, Garcia GE, Xia Y, Siani MA, Botti P, Wilson CB, Harrison JK, Bacon KB: Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1. Kidney Int 1999; 56: 612-620.
3. Higgins JP, Wang L, Kambham N, Montgomery K, Mason V, Vogelmann SU, Lemley KV, Brown PO, Brooks JD, van de Rijn M: Gene expression in the normal adult human kidney assessed by complementary DNA microarray. Mol Biol Cell 2004; 15: 649-656.
4. Gharaee-Kermani M, Denholm EM, Phan SH: Costimulation of fibroblast collagen and transforming growth factor β1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 1996; 271: 17779-17784.
5. Yamamoto T, Eckes B, Krieg T: Effect of interleukin- 10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor β and monocyte chemoattractant protein-1. Biochem Biophys Res Commun 2001; 281: 200-205.
6. Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, Gutierrez-Ramos JC: RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med 1997; 185: 1371-1380.
7. Chandrasekar B, Mummidi S, Perla RP, Bysani S, Dulin NO, Liu F, Melby PC: Fractalkine (CX3CL1) stimulated by nuclear factor κB-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Biochem J 2003; 373: 547-558.
8. Perros F, Dorfmüller P, Souza R, Durand- Gasselin I, Godot V, Capel F, Adnot S, Eddahibi S, Mazmanian M, Fadel E, Hervé P, Simonneau G, Emilie D, Humbert M: Fractalkine- induced smooth muscle cell proliferation in pulmonary hypertension. Eur Respir J 2007; 29: 937-943.
9. Cuellar LM, Fujinaka H, Yamamoto K, Miyamoto M, Tasaki M, Zhao L, Tamer I, Yaoita E, Yoshida Y, Yamamoto T: Identification and localization of novel genes preferentially expressed in human kidney glomerulus. Nephrology 2009; 14: 94-104.
10. Kawasaki K, Yaoita E, Yamamoto T, Kihara I: Depletion of CD8-positive cells in nephrotoxic serum nephritis of WKY rats. Kidney Int 1992; 41: 1517-1526.
11. Yaoita E, Yamamoto T, Saito M, Kawasaki K, Kihara I: Desmin-positive epithelial cells outgrowing from rat encapsulated glomeruli. Eur J Cell Biol 1991; 54: 140-149.
12. Ka SM, Rifai A, Chen JH, Cheng CW, Shua HA, Lee HS, Lin YF, Hsu LF, Chen A: Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease. Nephrol Dial Transpl 2006; 21: 288-298.
13. Mundel P: Synaptopodin: an actin-associated protein of telencephalic dendrites and of podocytes in the kidney glomerulus. Ann Anat 1998; 180: 391-392.
14. Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ, Raines EW: Tumor necrosis factor-α-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 2001; 276: 37993-38001.
15. Chen YM, Tu CJ, Hung KY, Wu KD, Tsai TJ, Hsieh BS: Inhibition by pentoxifylline of TNF-α-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-κB down-regulation. Br J Pharmacol 2003; 138: 950-958.
16. Chen YM, Hu-Tsai MI, Lin SL, Tsai TJ, Hsieh BS: Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti- Thy1 glomerulonephritis in rats. Nephrol Dial Transpl 2003; 18: 2505-2514.
17. Garcia GE, Truong LD, Li P, Zhang P, Johnson RJ, Wilson CB, Lili Feng L: Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis. Am J Pathol 2007; 170: 1485-1496.
18. Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A: Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. J Immunol 2007; 178: 8064-8072.
19. Yaoita E, Yao J, Yoshida Y, Morioka T, Nameta M, Takata T, Kamiie J, Fujinaka H, Oite T, Yamamoto T: Up-regulation of connexin43 in glomerular podocytes in response to injury. Am J Pathol 2002; 161: 1597-1606.
20. Nagai M, Yaoita E, Yoshida Y, Kuwano R, Nameta M, Ohshiro K, Isome M, Fujinaka H, Suzuki S, Suzuki J, Suzuki H, Yamamoto T: Coxsackievirus and adenovirus receptor, a tight junction membrane protein, is expressed in glomerular podocytes in the kidney. Lab Invest 2003; 83: 901-911.
21. Yaoita E, Kurihara H, Yoshida Y, Inoue T, Matsuki A, Sakai T, Yamamoto T: Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney. Kidney Int 2005; 68: 542-551.
22. Koziolek MJ, Schmid H, Cohen CD, Blaschke S, Hemmerlein B, Zapf A, Müller GA, Strutz F: Potential role of fractalkine receptor expression in human renal fibrogenesis. Kidney Int 2007; 72: 599-607. (Pubitemid 47312792)
23. Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H: Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol 2002; 168: 6244-6252.
24. Segerer S, Nelson PJ, Schlöndorff D: Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000; 11: 152-176.
25. Muehlhoefer A, Saubermann LJ, Gu X, Luedtke- Heckenkamp K, Xavier R, Blumberg RS, Podolsky DK, MacDermott RP, Reinecker HC: Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 2000; 164: 3368-3376.
26. Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR: The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol 2001; 158: 855-866.
27. Han GD, Koike H, Nakatsue T, Suzuki K, Yoneyama H, Narumi S, Kobayashi N, Mundel P, Shimizu F, Kawachi H: IFN-inducible protein- 10 has a differential role in podocyte during Thy 1.1 glomerulonephritis. J Am Soc Nephrol 2003; 14: 3111-3126.
28. Han GD, Suzuki K, Koike H, Suzuki K, Yoneyama H, Narumi S, Shimizu F, Kawachi H: IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. J Am Soc Nephrol 2006; 17: 442-453.
29. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ: A new class of membrane-bound chemokine with a CX3C motif. Nature 1997; 385: 640-644.
30. Rossi DL, Hardiman G, Copeland NG, Gilbert DJ, Jenkins N, Zlotnik A, Bazan JF: Cloning and characterization of a new type of mouse chemokine. Genomics 1998; 47: 163-170.
31. Harrison JK, Jiang Y, Chen S, Xia Y, Maciejewski D, McNamara RK, Streit WJ, Salafranca MN, Adhikari S, Thompson DA, Botti P, Bacon KB, Feng L: Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 1998; 95: 10896-10901.
32. Schwaeble WJ, Stover CM, Schall TJ, Dairaghi DJ, Trinder PK, Linington C, Iglesias A, Schubart A, Lynch NJ, Weihe E, Schafer MK: Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Lett 1998; 439: 203-207.
33. Cook DN, Chen SC, Sullivan LM, Manfra DJ, Wiekowski MT, Prosser DM, Vassileva G, Lira SA: Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol 2001; 21: 3159-3165.