Combined homology modelling and evolutionary significance evaluation of missense mutations in blood clotting factor VIII to highlight aspects of structure and function

Haemophilia

Volumn 15, Issue 4, 2009, Pages 932-941

  Markoff, Arseni ^a   Gerke, V ^a   Bogdanova, N ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

FVIII; Grantham Matrix Score; Haemophilia A; Homology modelling; Missense mutations; SNP

Indexed keywords

AMINO ACID; BLOOD CLOTTING FACTOR 8; VON WILLEBRAND FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; HEMOPHILIA A; HUMAN; MISSENSE MUTATION; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOLECULAR STABILITY; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PREDICTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

EID: 67649855137     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2009.02009.x     Document Type: Article

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