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Volumn 21, Issue 5, 2009, Pages 709-717

Effect of the conceptus on uterine prostaglandin-F2α and prostaglandin-E2 release and synthesis during the periimplantation period in the pig

Author keywords

Early pregnancy; Prostaglandins; Uterus

Indexed keywords

ESTRADIOL; MESSENGER RNA; PROSTAGLANDIN E2; PROSTAGLANDIN E2 SYNTHASE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

EID: 67649745870     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD08236     Document Type: Article
Times cited : (5)

References (39)
  • 2
    • 33748553382 scopus 로고    scopus 로고
    • Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy
    • doi:10.1095/BIOLREPROD.105.046557
    • Ashworth, M. D., Ross, J. W., Hu, J., White, F. J., Stein, D. R., DeSilva, U., Johnson, G. A., Spencer, T. E., and Geisert, R. D. (2006). Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy. Biol. Reprod. 74, 1007-1015. doi:10.1095/BIOLREPROD.105.046557
    • (2006) Biol. Reprod , vol.74 , pp. 1007-1015
    • Ashworth, M.D.1    Ross, J.W.2    Hu, J.3    White, F.J.4    Stein, D.R.5    DeSilva, U.6    Johnson, G.A.7    Spencer, T.E.8    Geisert, R.D.9
  • 3
    • 0017408217 scopus 로고
    • 2α by uterine endometrium
    • doi:10.1016/0090-6980(77)90185-X
    • 2α by uterine endometrium. Prostaglandins 14, 397-401. doi:10.1016/0090-6980(77)90185-X
    • (1977) Prostaglandins , vol.14 , pp. 397-401
    • Bazer, F.W.1    Thatcher, W.W.2
  • 4
    • 33749610147 scopus 로고    scopus 로고
    • The expression of short form of leptin receptor gene during early pregnancy in the pig examined by quantitative real time RT-PCR
    • Bogacka, I., Przała, J., Siawrys, G., Kamiński, T., and Smolińska, N. (2006). The expression of short form of leptin receptor gene during early pregnancy in the pig examined by quantitative real time RT-PCR. J. Physiol. Pharmacol. 57, 479-489.
    • (2006) J. Physiol. Pharmacol , vol.57 , pp. 479-489
    • Bogacka, I.1    Przała, J.2    Siawrys, G.3    Kamiński, T.4    Smolińska, N.5
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quanti-tation of microgram quantities of protein utilizing the principle of protein-dye binding
    • doi:10.1016/0003-2697(76)90527-3
    • Bradford, M. M. (1976). A rapid and sensitive method for the quanti-tation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254. doi:10.1016/0003-2697(76)90527-3
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 6
    • 0037593996 scopus 로고    scopus 로고
    • Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts
    • Chartrand, R., Matte, J. J., Lessard, M., Chouinard, P. Y., Giguère, A., and Laforest, J. P. (2003). Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts. J. Anim. Sci. 81, 726-734.
    • (2003) J. Anim. Sci , vol.81 , pp. 726-734
    • Chartrand, R.1    Matte, J.J.2    Lessard, M.3    Chouinard, P.Y.4    Giguère, A.5    Laforest, J.P.6
  • 8
    • 0027758914 scopus 로고
    • Studies of uterine secretions and products of primary cultures of endometrial cells in pigs
    • Davis, D. L., and Blair, R. M. (1993). Studies of uterine secretions and products of primary cultures of endometrial cells in pigs. J. Reprod. Fertil. Suppl. 48, 143-155.
    • (1993) J. Reprod. Fertil. Suppl , vol.48 , pp. 143-155
    • Davis, D.L.1    Blair, R.M.2
  • 9
    • 0020955865 scopus 로고
    • Prostaglandins in swine blastocysts
    • doi:10.1095/ BIOLREPROD28.5.1114
    • Davis, D. L., Pakrasi, P. L., and Dey, S. K. (1983). Prostaglandins in swine blastocysts. Biol. Reprod. 28, 1114-1118. doi:10.1095/ BIOLREPROD28.5.1114
    • (1983) Biol. Reprod , vol.28 , pp. 1114-1118
    • Davis, D.L.1    Pakrasi, P.L.2    Dey, S.K.3
  • 10
    • 0029952679 scopus 로고    scopus 로고
    • Identification and distribution of prostaglandin E receptors on porcine luteal cells
    • doi:10.1095/BIOLREPROD54.6.1366
    • Feng, S. M., and Almond, G. W. (1996). Identification and distribution of prostaglandin E receptors on porcine luteal cells. Biol. Reprod. 54, 1366- 1374. doi:10.1095/BIOLREPROD54.6.1366
    • (1996) Biol. Reprod , vol.54 , pp. 1366-1374
    • Feng, S.M.1    Almond, G.W.2
  • 11
    • 0022220239 scopus 로고
    • Steroid metabolism by endometrial and conceptus tissues during early pregnancy and pseudopregnancy in gilts
    • doi:10.1530/ JRF.0.0750069
    • Fischer, H. E., Bazer, F. W., and Fields, M. J. (1985). Steroid metabolism by endometrial and conceptus tissues during early pregnancy and pseudopregnancy in gilts. J. Reprod. Fertil. 75, 69-78. doi:10.1530/ JRF.0.0750069
    • (1985) J. Reprod. Fertil , vol.75 , pp. 69-78
    • Fischer, H.E.1    Bazer, F.W.2    Fields, M.J.3
  • 12
    • 0020041017 scopus 로고
    • Uterine blood flow and uterine arterial, venous and luminal concentrations of estrogen on Days 11, 13 and 15 after estrus in pregnant and nonpregnant sows
    • doi:10.1530/JRF.0.0640185
    • Ford, S. P., Christenson, R. K., and Ford, J. J. (1982). Uterine blood flow and uterine arterial, venous and luminal concentrations of estrogen on Days 11, 13 and 15 after estrus in pregnant and nonpregnant sows. J. Reprod. Fertil. 64, 185-190. doi:10.1530/JRF.0.0640185
    • (1982) J. Reprod. Fertil , vol.64 , pp. 185-190
    • Ford, S.P.1    Christenson, R.K.2    Ford, J.J.3
  • 13
    • 37849048505 scopus 로고    scopus 로고
    • Secretion of estradiol-17β by porcine endometrium and myometrium during early pregnancy and luteolysis
    • doi:10.1016/J.THERIOGENOLOGY. 2007.09.023
    • Franczak, A., and Kotwica, G. (2008). Secretion of estradiol-17β by porcine endometrium and myometrium during early pregnancy and luteolysis. Theriogenology 69, 283-289. doi:10.1016/J.THERIOGENOLOGY. 2007.09.023
    • (2008) Theriogenology , vol.69 , pp. 283-289
    • Franczak, A.1    Kotwica, G.2
  • 14
    • 33747177037 scopus 로고    scopus 로고
    • Expression of enzymes of cyclooxygenase pathway and secretion of prostaglandin E2 and F2α by porcine myometrium during luteolysis and early pregnancy
    • doi:10.1016/J.THERIOGENOLOGY.2006.03.001
    • Franczak, A., Kotwica, G., Kurowicka, B., Oponowicz, A., WocławekPotocka, I., and Petroff, B. K. (2006). Expression of enzymes of cyclooxygenase pathway and secretion of prostaglandin E2 and F2α by porcine myometrium during luteolysis and early pregnancy.Theriogenol-ogy 66, 1049-1056. doi:10.1016/J.THERIOGENOLOGY.2006.03.001
    • (2006) Theriogenol-ogy , vol.66 , pp. 1049-1056
    • Franczak, A.1    Kotwica, G.2    Kurowicka, B.3    Oponowicz, A.4    WocławekPotocka, I.5    Petroff, B.K.6
  • 15
    • 0017621377 scopus 로고
    • A study of prostaglandin F2α as a luteolysin in swine. III. Effects of estradiol valer-ate on prostaglandin F, progestins, estrone and estradiol concentrations in utero-ovarian vein of nonpregnant gilts
    • doi:10.1016/0090-6980(77)90295-7
    • Frank, M., Bazer, F. W., Thatcher,W. W., and Wilcox, C. J. (1977).A study of prostaglandin F2α as a luteolysin in swine. III. Effects of estradiol valer-ate on prostaglandin F, progestins, estrone and estradiol concentrations in utero-ovarian vein of nonpregnant gilts. Prostaglandins 14, 1183-1196. doi:10.1016/0090-6980(77)90295-7
    • (1977) Prostaglandins , vol.14 , pp. 1183-1196
    • Frank, M.1    Bazer, F.W.2    Thatcher, W.W.3    Wilcox, C.J.4
  • 16
    • 0020361030 scopus 로고
    • Establishment of pregnancy in the pig. I. Interrelationships between preimplantation development of the pig blastocyst and uterine endometrial secretion
    • doi:10.1095/ BIOLREPROD27.4.925
    • Geisert, R. D., Renegar, R. H., Thatcher, F. W., Roberts, R. M., and Bazer, F. W. (1982). Establishment of pregnancy in the pig. I. Interrelationships between preimplantation development of the pig blastocyst and uterine endometrial secretion. Biol. Reprod. 27, 925-939. doi:10.1095/ BIOLREPROD27.4.925
    • (1982) Biol. Reprod , vol.27 , pp. 925-939
    • Geisert, R.D.1    Renegar, R.H.2    Thatcher, F.W.3    Roberts, R.M.4    Bazer, F.W.5
  • 18
    • 0015088426 scopus 로고
    • Time course of serum estrogen and luteinising hormone (LH) concentrations during the menstrual cycle of the rhesus monkey
    • Hotchkiss, J., Atkinson, L. E., and Knobil, E. (1971). Time course of serum estrogen and luteinising hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology 89, 177-183.
    • (1971) Endocrinology , vol.89 , pp. 177-183
    • Hotchkiss, J.1    Atkinson, L.E.2    Knobil, E.3
  • 19
    • 0020392360 scopus 로고
    • Uterine secretion of prostaglandin F2α in anaesthetized pigs during the oestrous cycle and early pregnancy
    • doi:10.1051/RND:19820712
    • Hunter, R. H. F., and Poyser, N. L. (1982). Uterine secretion of prostaglandin F2α in anaesthetized pigs during the oestrous cycle and early pregnancy. Reprod. Nutr. Dev. 22, 1013-1023. doi:10.1051/RND:19820712
    • (1982) Reprod. Nutr. Dev , vol.22 , pp. 1013-1023
    • Hunter, R.H.F.1    Poyser, N.L.2
  • 20
    • 0024989196 scopus 로고
    • Uterine and ovarian countercurrent pathways in the control of ovarian function in the pig
    • Krzymowski, T., Kotwica, J., and Stefańczyk-Krzymowska, S. (1990). Uterine and ovarian countercurrent pathways in the control of ovarian function in the pig. J. Reprod. Fertil. Suppl. 40, 179-191.
    • (1990) J. Reprod. Fertil. Suppl , vol.40 , pp. 179-191
    • Krzymowski, T.1    Kotwica, J.2    Stefańczyk-Krzymowska, S.3
  • 21
    • 0026589661 scopus 로고
    • Effect of intrauterine application of oestradiol-17β and prostaglandin E2 on the porcine estrous cycle and uterine endocrinology
    • doi:10.1530/ JRF.0.0940381
    • Laforest, J. P., and King, G. J. (1992). Effect of intrauterine application of oestradiol-17β and prostaglandin E2 on the porcine estrous cycle and uterine endocrinology. J. Reprod. Fertil. 94, 381-394. doi:10.1530/ JRF.0.0940381
    • (1992) J. Reprod. Fertil , vol.94 , pp. 381-394
    • Laforest, J.P.1    King, G.J.2
  • 22
    • 0017622545 scopus 로고
    • A study of prostaglandin F2αas a luteolysin in swine. II. Characterisation and comparison of prostaglandin F, estrogens and progestin concentrations in utero-ovarian vein plasma of nonpreg-nant and pregnant gilts
    • doi:10.1016/0090- 6980(77)90268-4
    • Moeljono, M. P. E., Thatcher, W. W., Bazer, F. W., Frank, M., Owens, L. J., and Wilcox, C. J. (1977). A study of prostaglandin F2αas a luteolysin in swine. II. Characterisation and comparison of prostaglandin F, estrogens and progestin concentrations in utero-ovarian vein plasma of nonpreg-nant and pregnant gilts. Prostaglandins 14, 543-555. doi:10.1016/0090- 6980(77)90268-4
    • (1977) Prostaglandins , vol.14 , pp. 543-555
    • Moeljono, M.P.E.1    Thatcher, W.W.2    Bazer, F.W.3    Frank, M.4    Owens, L.J.5    Wilcox, C.J.6
  • 23
    • 0024415504 scopus 로고
    • Luteal production of steroids and prostaglandins during stimulated early pregnancy in primate: Differential regulation of steroid production by chorionic gonadotropin
    • doi:10.1095/ BIOLREPROD41.3.393
    • Ottobre, J. S., Houmard, B. S., and Ottobre, A. C. (1989). Luteal production of steroids and prostaglandins during stimulated early pregnancy in primate: differential regulation of steroid production by chorionic gonadotropin. Biol. Reprod. 41, 393-400. doi:10.1095/ BIOLREPROD41.3.393
    • (1989) Biol. Reprod , vol.41 , pp. 393-400
    • Ottobre, J.S.1    Houmard, B.S.2    Ottobre, A.C.3
  • 24
    • 0033967971 scopus 로고    scopus 로고
    • Different actions of noradrenaline and nitric oxide on the output of prostaglandins and progesterone in cultured bovine luteal cells
    • doi:10.1016/S0090-6980(99)00046-5
    • Skarżyński, D. J., and Okuda, K. (2000). Different actions of noradrenaline and nitric oxide on the output of prostaglandins and progesterone in cultured bovine luteal cells. Prostaglandins Other Lipid Mediat. 60, 35-47. doi:10.1016/S0090-6980(99)00046-5
    • (2000) Prostaglandins Other Lipid Mediat , vol.60 , pp. 35-47
    • Skarżyński, D.J.1    Okuda, K.2
  • 25
    • 0028094508 scopus 로고
    • Total content of prostaglandin F2α in the endometrium and myometrium from various sections of the porcine uterine horn during the estrous cycle
    • doi:10.1016/0090-6980(94)90088-4
    • Stefańczyk-Krzymowska, S., Szafrańska, B., Kamiński, T., and Krzy-mowski, T. (1994). Total content of prostaglandin F2α in the endometrium and myometrium from various sections of the porcine uterine horn during the estrous cycle. Prostaglandins 48, 99-108. doi:10.1016/0090-6980(94)90088-4
    • (1994) Prostaglandins , vol.48 , pp. 99-108
    • Stefańczyk-Krzymowska, S.1    Szafrańska, B.2    Kamiński, T.3    Krzy-mowski, T.4
  • 26
    • 27844470730 scopus 로고    scopus 로고
    • Local transfer of prostaglandin E2 into the ovary and its retrograde transfer into the uterus in early pregnant sows
    • doi:10.1113/EXPPHYSIOL.2005.031112
    • Stefańczyk-Krzymowska, S., Chłopek, J., Grzegorzewski, W., and Radomski, M. (2005). Local transfer of prostaglandin E2 into the ovary and its retrograde transfer into the uterus in early pregnant sows. Exp. Physiol. 90, 807-814. doi:10.1113/EXPPHYSIOL.2005.031112
    • (2005) Exp. Physiol , vol.90 , pp. 807-814
    • Stefańczyk-Krzymowska, S.1    Chłopek, J.2    Grzegorzewski, W.3    Radomski, M.4
  • 27
    • 0022214379 scopus 로고
    • Steroid hormones in uterine washings and in plasma of gilts between Days 9 and 15 after coitus
    • doi:10.1530/JRF.0.0750209
    • Stone, B. A., and Seamark, R. F. (1985). Steroid hormones in uterine washings and in plasma of gilts between Days 9 and 15 after coitus. J Reprod. Fertil. 75, 209-221. doi:10.1530/JRF.0.0750209
    • (1985) J Reprod. Fertil , vol.75 , pp. 209-221
    • Stone, B.A.1    Seamark, R.F.2
  • 28
    • 0022855653 scopus 로고
    • Production of steroids and release of prostaglandins by spherical pig blastocyst in vitro
    • Stone, B. A., Seamark, R. F., Kelly, R. W., and Deam, S. (1986). Production of steroids and release of prostaglandins by spherical pig blastocyst in vitro. Aust. J. Biol. Sci. 39, 283-293.
    • (1986) Aust. J. Biol. Sci , vol.39 , pp. 283-293
    • Stone, B.A.1    Seamark, R.F.2    Kelly, R.W.3    Deam, S.4
  • 29
    • 0043168774 scopus 로고    scopus 로고
    • Primary antisera-selected steroids or proteins and secondary antisera against γ-globulins - an available tool for studies of reproductive processes
    • Szafrańska, B., Ziȩcik, A. J., and Okrasa, S. (2002). Primary antisera-selected steroids or proteins and secondary antisera against γ-globulins - an available tool for studies of reproductive processes. Reprod. Biol. 2, 187-204.
    • (2002) Reprod. Biol , vol.2 , pp. 187-204
    • Szafrańska, B.1    Ziȩcik, A.J.2    Okrasa, S.3
  • 30
    • 0030987620 scopus 로고    scopus 로고
    • Up-regulation of oxytocin receptors in porcine endometrium by adenosine 3′,5′-monophosphate
    • doi:10.1095/ BIOLREPROD57.4.723
    • Uenoyama, Y., Hattori, S.-I., Miyake, M., and Okuda, K. (1997). Up-regulation of oxytocin receptors in porcine endometrium by adenosine 3′,5′-monophosphate. Biol. Reprod. 57, 723-728. doi:10.1095/ BIOLREPROD57.4.723
    • (1997) Biol. Reprod , vol.57 , pp. 723-728
    • Uenoyama, Y.1    Hattori, S.-I.2    Miyake, M.3    Okuda, K.4
  • 31
    • 34748915209 scopus 로고    scopus 로고
    • Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase/PG 9-ketoreductase in the pig
    • doi:10.1677/JOE-07-0155
    • Wacławik, A., and Ziȩcik, A. (2007). Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase/PG 9-ketoreductase in the pig. J. Endocrinol. 194, 499-510. doi:10.1677/JOE-07-0155
    • (2007) J. Endocrinol , vol.194 , pp. 499-510
    • Wacławik, A.1    Ziȩcik, A.2
  • 32
    • 29344440054 scopus 로고    scopus 로고
    • Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium
    • doi:10.1210/EN.2005-0880
    • Wacławik, A., Rivero-Muller, A., Blitek, A., Kaczmarek, M. M., Brokken, L. S. J., Watanabe, K., Rahman, N. A., andZiȩcik, A. J. (2006). Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium. Endocrinology 147, 210-221. doi:10.1210/EN.2005-0880
    • (2006) Endocrinology , vol.147 , pp. 210-221
    • Wacławik, A.1    Rivero-Muller, A.2    Blitek, A.3    Kaczmarek, M.M.4    Brokken, L.S.J.5    Watanabe, K.6    Rahman, N.A.7    andZiȩcik, A.J.8
  • 33
    • 44849100771 scopus 로고    scopus 로고
    • The influence of embryo presence on prostaglandin synthesis and prostaglandin E2 and F2α content in corpora lutea during periimplantation period in the pig
    • doi:10.1002/MRD.20862
    • Wasielak, M., Głowacz, M., Kamińska, K., Wacławik, A., and Bogacki, M. (2008). The influence of embryo presence on prostaglandin synthesis and prostaglandin E2 and F2α content in corpora lutea during periimplantation period in the pig. Mol. Reprod. Dev. 75, 1208-1216. doi:10.1002/MRD.20862
    • (2008) Mol. Reprod. Dev , vol.75 , pp. 1208-1216
    • Wasielak, M.1    Głowacz, M.2    Kamińska, K.3    Wacławik, A.4    Bogacki, M.5
  • 34
    • 0037124229 scopus 로고    scopus 로고
    • Differential expression of cyclooxygenase-2 around the time of elongation in the pig conceptus
    • doi:10.1016/S0378-4320(02)00029-5
    • Wilson, M. E., Fahrenkrug, S. C, Smith, T. P., Rohrer, G. A., and Ford, S. P. (2002). Differential expression of cyclooxygenase-2 around the time of elongation in the pig conceptus. Anim. Reprod. Sci. 71, 229-237. doi:10.1016/S0378-4320(02)00029-5
    • (2002) Anim. Reprod. Sci , vol.71 , pp. 229-237
    • Wilson, M.E.1    Fahrenkrug, S.C.2    Smith, T.P.3    Rohrer, G.A.4    Ford, S.P.5
  • 35
    • 0030778224 scopus 로고    scopus 로고
    • Ontogeny of elongation and gene expression in the early developing porcine conceptuses
    • doi:10.1095/BIOLREPROD57.5.1256
    • Yelich, J. V., Pomp, D., and Geisert, R. (1997). Ontogeny of elongation and gene expression in the early developing porcine conceptuses. Biol. Reprod. 57, 1256-1265. doi:10.1095/BIOLREPROD57.5.1256
    • (1997) Biol. Reprod , vol.57 , pp. 1256-1265
    • Yelich, J.V.1    Pomp, D.2    Geisert, R.3
  • 36
    • 0019225592 scopus 로고
    • A study of prostaglandin F2α as luteolysisn in swine. V Comparison of prostaglandin F, progestins, estrone and estradiol in uterine flushings from pregnant and non-pregnant gilts
    • doi:10.1016/0090-6980(80)90137-9
    • Zavy, M. T., Bazer, F W, Thatcher, W W, and Wilcox, C. J. (1980). A study of prostaglandin F2α as luteolysisn in swine. V Comparison of prostaglandin F, progestins, estrone and estradiol in uterine flushings from pregnant and non-pregnant gilts. Prostaglandins 20, 837-851. doi:10.1016/0090-6980(80)90137-9
    • (1980) Prostaglandins , vol.20 , pp. 837-851
    • Zavy, M.T.1    Bazer, F.W.2    Thatcher, W.W.3    Wilcox, C.J.4
  • 37
    • 0025917940 scopus 로고
    • Prostaglandin E2 and F2α secretion by glandular and stromal cells of the pig endometrium in vitro: Effects of estradiol-17β, progesterone and day of pregnancy
    • doi:10.1016/0090-6980(91)90074-P
    • Zhang, Z., and Davis, D. L. (1991). Prostaglandin E2 and F2α secretion by glandular and stromal cells of the pig endometrium in vitro: effects of estradiol-17β, progesterone and day of pregnancy. Prostaglandins 42, 151-162. doi:10.1016/0090-6980(91)90074-P
    • (1991) Prostaglandins , vol.42 , pp. 151-162
    • Zhang, Z.1    Davis, D.L.2
  • 38
    • 0036638204 scopus 로고    scopus 로고
    • Old, new and the newest concepts of inhibition of luteolysis during early pregnancy in pig
    • doi:10.1016/S0739-7240(02)00162-5
    • Ziȩcik, A. J. (2002). Old, new and the newest concepts of inhibition of luteolysis during early pregnancy in pig. Domest. Anim. Endocrinol. 23, 265-275. doi:10.1016/S0739-7240(02)00162-5
    • (2002) Domest. Anim. Endocrinol , vol.23 , pp. 265-275
    • Ziȩcik, A.J.1


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