Transmission dynamics and mechanisms of endemicity of scrapie in the UK sheep population

Epidemiology and Infection

Volumn 137, Issue 6, 2009, Pages 762-774

  Truscott, J E ^a   Ferguson, N M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Modelling; Sheep; TSE; United Kingdom

Indexed keywords

ARTICLE; BREEDING; CONTROLLED STUDY; DISEASE TRANSMISSION; ENDEMIC DISEASE; GENETIC VARIABILITY; MORTALITY; NONHUMAN; PERSISTENT INFECTION; POPULATION STRUCTURE; PREVALENCE; PRION DISEASE; PROBABILITY; SCRAPIE; SHEEP DISEASE; SIMULATION; UNITED KINGDOM; ANIMAL; ANIMAL DISEASE; BIOLOGICAL MODEL; FEMALE; SHEEP;

ANIMALS; ENDEMIC DISEASES; FEMALE; GREAT BRITAIN; MODELS, BIOLOGICAL; PREVALENCE; SCRAPIE; SHEEP;

EID: 67649695197     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268808001052     Document Type: Article

References (25)

1. Foster JD, Hope J, Fraser H. Transmission of bovine spongiform encephalopathy to sheep and goats. Veterinary Record 1993; 14 339-341.
2. Defra. National scrapie plan for Great Britain, 2005. (www.defra.gov.uk/corporate/regulat/forms/Ahealth/nsp/nsp1.pdf). Accessed July 2008.
3. Defra. Compulsory scrapie flocks scheme booklet, August 2006 (http://www.defra.gov.uk/corporate/regulat/forms/Ahealth/nsp/nsp39.pdf). Accessed July 2008.
4. EC. Regulation (EC) No. 999/2001 of the European Parliament and of the Council of 22 May 2001 laying down rules for the prevention, control and eradication of certain transmissible spongiform encephalopathies. Official Journal of the European Union 2001; L147: 1-40.
5. EC. Commission decision of 13 February 2003 laying down minimum requirements for the establishment of breeding programmes for resistance to transmissible spongiform encephalopathies in sheep. Official Journal of the European Union 2003; L41: 41-45.
6. EC. Commission regulation (EC) No. 1915/2003 of 30 October 2003 amending annexes vii, viii and ix to regulation (EC) no. 999/2001 of the European Parliament and of the Council as regards the trade and import of ovine and caprine animals and the measures following the confirmation of transmissible spongiform encephalopathies in bovine, ovine and caprine animals. Official Journal of the European Union 2003; L283: 29-33.
7. Hagenaars TJ, et al. Dynamics of a scrapie outbreak in a flock of Romanov sheep - estimation of transmission parameters. Epidemiology and Infection 2003; 2: 1015-1022.
8. Hagenaars TJ, et al. The transmission dynamics of the aetiological agent of scrapie in a sheep flock. Mathematical Biosciences 2000; 2: 117-135.
9. Pollott G, Stone D. The breeding structure of the British sheep industry, 2003. Defra, 2006 (http://www.defra.gov.uk/animalh/bse/ othertses/scrapie/nsp/publicatsrpts/pollott2003.pdf). Accessed July 2008.
10. Eglin RD, et al. Frequencies of PrP genotypes in 38 breeds of sheep sampled in the national scrapie plan for Great Britain. Veterinary Record 2005; 14: 433-437.
11. Defra. Animal health and welfare : BSE - GB weekly cumulative statistics. Defra, 2007 (http://www.defra.gov.uk/animalh/bse/statistics/ pdf/weekly.pdf). Accessed July 2008.
12. Jeffrey M, et al. Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies. Journal of Comparative Pathology 2001; 1: 48-57.
13. van Keulen LJM, Vromans MEW, Van Zijderveld FG. Early and late pathogenesis of natural scrapie infection in sheep. APMIS 2002; 1: 23-32.
14. Del Rio Vilas V, et al. Analysis of data from the passive surveillance of scrapie in Great Britain between 1993 and 2002. Veterinary Record 2006; 24: 799-804.
15. Hoinville LJ, et al. Descriptive epidemiology of scrapie in Great Britain : Results of a postal survey. Veterinary Record 2000; 16: 455-461.
16. Sivam SK, et al. Descriptive analysis of the results of an anonymous postal survey of the occurence of scrapie in Great Britain in 2002. Veterinary Record 2006; 15: 501-506.
17. Gubbins S. A modelling framework to describe the spread of scrapie between sheep flocks in Great Britain. Preventive Veterinary Medicine 2005; 67: 143-156.
18. Gubbins S, Roden JA. Breeding programmes for TSE resistance in British sheep - II. Assessing the impact on the prevalence and incidence of scrapie. Preventive Veterinary Medicine 2006; 1: 17-31.
19. Kiss I, Green D, Kao R. The network of sheep movements within Great Britain : Network properties and their implications for infectious disease spread. Journal of the Royal Society Interface 2006; 10 669-677.
20. Ferguson NM, et al. Estimating the human health risk from possible BSE infection of the British sheep flock. Nature 2002; 6870: 420-424.
21. McLean AR, et al. Scrapie transmission in Britain : A recipe for a mathematical model. Proceedings of the Royal Society of London, Series B: Biological Sciences 1999; 1437: 2531-2538.
22. St Rose SG, et al. Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies. BMC Infectious Diseases 2006; 6 (5).
23. Baylis M, et al. Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology 2004; 85: 2735-2740.
24. Diekmann O, Heesterbeek JAP. Mathematical Epidemiology of Infectious Diseases : Model Building, Analysis and Interpretation (Mathematical and Computational Biology series). Wiley, 2000.
25. Kao RR, Gravenor MB, McLean AR. Modelling the national scrapie eradication programme in the UK. Mathematical Biosciences 2001; 2: 61-76.