6-Mercaptopurine as an alternative to azathioprine in azathioprine-induced hepatoxicity

Inflammatory Bowel Diseases

Volumn 15, Issue 2, 2009, Pages 318-319

  Kiefer, Krystina ^a   El Matary, Wael ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE; PREDNISONE;

ABDOMINAL PAIN; ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; CASE REPORT; CHILD; CROHN DISEASE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; HUMAN; INFLAMMATORY INFILTRATE; LETHARGY; LETTER; LIVER TOXICITY; MALE; NAUSEA; PRIORITY JOURNAL; SCHOOL CHILD; SIDE EFFECT; WEIGHT REDUCTION;

6-MERCAPTOPURINE; ADOLESCENT; AZATHIOPRINE; CHILD; CROHN DISEASE; HEPATITIS, TOXIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; TREATMENT OUTCOME;

EID: 67649675036     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20603     Document Type: Letter

References (8)

1. Gisbert J, Gonzalez-Lama Y, Mate J. Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review. Am J Gastroenterol. 2007;102:1518-1527.
2. Su C, Lichtenstein G. Treatment of inflammatory bowel disease with azathioprine and 6-mercaptopurine. Gastroenterol Clin N Am. 2004;33:209-234.
3. Bowen D, Selby W. Use of 6-mercaptopurine in patients with inflammatory bowel disease previously intolerant of azathioprine. Dig Dis Sci. 2000;45:1810-1813.
4. Boulton-Jones J, Pritchard K, Mahmoud A. The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy. Aliment Pharmacol Ther. 2000;14:1561-1565.
5. Lees C, Maan A, Hansoti B, et al. Tolerability Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2008;27:220-227.
6. Gearry R, Barclay M. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J Gastroenerol Hepatol. 2005;20:1149-1157.
7. Ooi C, Bohane T, Lee D, et al. Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Aliment Pharmacol Ther. 2007;25:941-947.
8. McGovern D, Travis S, Duley J, et al. Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity. Gastroenterology. 2002;122:838-839.