Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation

Experimental and Molecular Pathology

Volumn 87, Issue 1, 2009, Pages 36-41

  Baral, Rathindranath ^a   Bose, Anamika ^a   Ray, Chinmoyee ^a   Paul, Sonali ^a   Pal, Smarajit ^a   Haque, Enamul ^a   Mishra, Bhagawan ^a   Pal, Debolina ^a   Nagpal, Jatin Kumar ^b   Panda, Chinmay Kumar ^a   Das, Bibhu Ranjan ^b  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b Molecular Diagnostics   (India)

Author keywords

Apoptosis; Bcl2; Caspase 3; Colorectal carcinoma; CRC cells; Cyclin D1; Peripheral blood mononuclear cells; STAT3

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CASPASE 3; CYCLIN D1; ENZYME ANTIBODY; PROTEIN BCL 2; STAT3 PROTEIN;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL; CANCER PATIENT; CELL PROTECTION; CLINICAL ARTICLE; COLON; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DATA ANALYSIS; EARLY DIAGNOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INDIAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION;

ADULT; APOPTOSIS; CARCINOEMBRYONIC ANTIGEN; CASPASE 3; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR CELLS, CULTURED; YOUNG ADULT;

EID: 67649668469     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.03.002     Document Type: Article

References (40)

1. Alvarez J.V., Febbo P.G., Ramaswamy S., Loda M., Richardson A., and Frank D.A. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 65 (2005) 5054-5062
2. Atreya R., and Neurath M.F. Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin. Rev. Allergy Immunol. 28 (2008) 187-196
3. Atreya R., and Neurath M.F. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr. Drug Targets 9 (2008) 369-374
4. Baral R.N. Tumor vaccine: current trends in antigen specific immunotherapy. Ind. J. Exp. Biol. 43 (2005) 389-406
5. Baral R.N., Sherrat A., Das R., Foon K.A., and Bhattacharya-Chatterjee M. Murine monoclonal anti-idiotype antibody as a surrogate antigen for human Her2/neu. Int. J. Cancer 92 (2001) 88-95
6. Barton B.E., Murphy T.F., Shu P., Huang H.F., Meyenhofen M., and Barton A. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol. Cancer Ther. 3 (2004) 1183-1191
7. Benchimol S., Fuks A., Jothy S., Becauchemin N., Shirota K., and Stanners C.P. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57 (1989) 327-334
8. Berinstein N.L. Carcinoembryonic antigen as a target for therapeutic anticancer vaccines: a review. J. Clin. Oncol. 20 (2002) 2197-2207
9. Bromberg J.F., Wrzeszczynska M.H., Devgan G., Zhao Y., Pestell R.G., and Albanese C. Stat3 as an oncogene. Cell 98 (1999) 295-303
10. Duffy S.A., Taylor J.M., Terrell J.E., Islam M., Li Y., Fowler K.E., Wolf G.T., and Teknos T.N. Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer 113 (2008) 671-673
11. Ferrand A., Bertrand C., Portolan G., Cui G., Carlson J., and Pradayrol L. Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors. Cancer Res. 65 (2005) 2770-2777
12. Foon K.A., Yannelli J., and Bhattacharya-Chatterjee M. Colorectal cancer as a model for immunotherapy. Clin. Cancer Res. 5 (1999) 225-236
13. Gangadharan P. Population based cancer registries-no. of cases and age adjusted rates. Cancer Registry Abstract, News Letter of the National Cancer Registry Programme - Vol VIII, No. 1, ICMR, New Delhi, New Delhi (2001) 59 2001
14. Garcia R., Bowman T.L., Niu G., Minton S., Muro-Caco C.A., and Cox C.E. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20 (2001) 2499-2513
15. Gordon J.N., Sabatino A.D., and Macdonald T.T. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr. Opin. Gastroenterol. 21 (2005) 431-437
16. Grandis J.R., Drenning S.D., Zeng Q., Watkins S.C., Melhem M.F., and Endo S. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4227-4232
17. Ishii M. Limitation of clinical usefulness of tumor marker. Gan To Kagaku Ryoho 22 (1995) 1139-1145
18. Itzkowitz S.H., and Present D.H. Consensus conference: colorectal cancer screening and surveillance in inflammatory bowel disease. Inflamm. Bowel Dis. 11 (2005) 314-321
19. Jing N., and Tweardy D.J. Targeting Stat3 in cancer therapy. Anticancer Drugs 16 (2005) 601-607
20. Landis S.H., Murray T., Bolden S., and Wingo P.A. Cancer strategies. CA. Cancer J. Clin. 48 (1998) 6-29
21. Leonard W.J., and O'Shea J.J. JAKs and STATs: biological implications. Ann. Rev. Immunol. 16 (1998) 293-322
22. Leu C.M., Wong F.H., Chang C., Huang S.F., and Hu C.P. Interleukin-6 acts as an antiapoptotic factor in human esophageal carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways. Oncogene 22 (2003) 7809-7818
23. Lee B.S., Park M., Cha H.Y., and Lee J.H. Hepatocyte growth factor induces delayed STAT3 phosphorylation through interleukin 6 expression. Cell Signal (2008) 2008 Nov 30. [Epub ahead of print]
24. Lovato P., Brender C., Agnholt J., Kelsen J., Kaltoft K., and Svejgaard A. Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278 (2003) 16777-16781
25. Martinez M.E. Primary prevention of colorectal cancer: lifestyle, nutrition, exercise, recent results. Cancer Res. 166 (2005) 177-211
26. Masuda M., Suzui M., Yasumatu R., Nakashima T., Kuratomi Y., and Azuma K. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res. 62 (2002) 3351-3355
27. Ma X.T., Wang S., Ye Y.J., Du R.Y., and Cui Z.R. Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma. Ai Zheng 22 (2003) 1135-1139
28. Ma X.T., Wang S., Ye Y.J., Du R.Y., Cui Z.R., and Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J. Gastroenterol. 10 (2004) 1569-1573
29. Mora L.B., Buettner R., Seigne J., Diaz J., Ahmad N., and Garcia R. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 62 (2002) 6659-6666
30. Nagpal J.K., Mishra R.K., and Das B.R. Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. Cancer 94 (2002) 2393-2400
31. Ordonez C., Screaton R.A., Ilantzis C., and Stanners C.P. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res. 60 (2000) 3419-3424
32. Park H.J., Kim Y.J., Leem K., Park S.J., Seo J.C., and Kim H.K. Coptis japonica root extract induces apoptosis through caspase3 activation in SNU-668 human gastric cancer cells. Phytother. Res. 19 (2005) 189-192
33. Pedranzini L., Leitch A., and Bromberg J. Stat3 is required for the development of skin cancer. J. Clin. Invest. 114 (2004) 720-728
34. Sinicrope F.A., Ruan S.B., Cleary K.R., Stephens L.C., Lee J.J., and Levin B. bcl2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55 (1995) 237-241
35. Sriuranpong V., Park J.I., Amornphimoltham P., Patel V., Nelkin B.D., and Gutkind J.S. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 63 (2003) 2948-2956
36. Suh H.N., Lee Y.J., and Han H.J. Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca(2+)/PKC and EGF receptor in primary cultured chicken hepatocytes. J. Cell Physiol. 218 (2008) 643-652
37. Thompson J., Grunert F., and Zimmermann W. CEA gene family: molecular biology and clinical perspectives. J. Clin. Lab. Anal. 5 (1991) 344-366
38. Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Op. Ther. Targets 8 (2004) 409-422
39. Wang T., Niu G., Kortylewski M., Burdelya L., Shain K., and Zhang S. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat. Med. 10 (2004) 48-54
40. Zushi S., Shinomura Y., Kiyohara T., Miyazaki Y., Kondo S., and Sugimachi M. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. Int. J. Cancer 78 (1998) 326-330