Identification of Hsp70 modulators through modeling of the substrate binding domain

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3828-3831

  Haney, Conor M ^a   Schneider, Corinne ^a   Beck, Barbara ^a   Brodsky, Jeffrey L ^a   Dömling, Alexander ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

HSP 70; Isocyanide; Modulator; Multi component reaction; Peptide recognition site; Protein protein interaction; Ugi reaction

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CYANIDE; HEAT SHOCK PROTEIN 70; PEPTIDE;

ARTICLE; BIGINELLI REACTION; BINDING SITE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR LIBRARY; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE RECOGNITION SITE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SYNTHESIS; UGI MULTICOMPONENT REACTION; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HSP70 HEAT-SHOCK PROTEINS; MODELS, CHEMICAL; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 67649660115     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.062     Document Type: Article

References (27)

1. Bukau B., and Horwich A.L. Cell 92 (1998) 351
2. Brodsky J.L., and Chiosis G. Curr. Top. Med. Chem. 6 (2006) 1215
3. Rohde M., Daugaard M., Jensen K.H., Nylandsted J., and Jäättelä M. Genes Dev. 19 (2005) 57
4. Yaglom J.A., Gabai V.L., and Sherman M.Y. Cancer Res. 67 (2007) 2373
5. Vargas-Roig L.M., Gago F.E., Tello O., Aznar J.C., and Ciocca D.R. Int. J. Cancer 79 (1998) 468
6. van der Weerd L., Lythgoe M.F., Badin R.A., Valentim L.M., Akbar M.T., de Belleroche J.S., Latchman D.S., and Gadian D.G. Exp. Neurol. 195 (2005) 257
7. Sherman M.Y., and Goldberg A.L. Neuron 29 (2001) 15
8. Fewell S.W., Smith C.M., Lyon M.A., Dumitrescu T.P., Wipf P., Day B.W., and Brodsky J.L. J. Biol. Chem. 279 (2004) 51131
9. Wright C.M., Chovatiya R.J., Jameson N.E., Turner D.M., Zhu G., Werner S., Huryn D.M., Pipas J.M., Day B.W., Wipf P., and Brodsky J.L. Bioorg. Med. Chem. 16 (2008) 3291
10. Wright C.M., et al. Virus Res. 141 (2009) 71
11. Shonhai A., Boshoff A., and Blatch G.L. Protein Sci. 16 (2007) 1803
12. Chiang A.N., Valderramos J.C., Balachandran R., Chovatiya R.J., Mead B.P., Schneider C., Bell S.L., Klein M.G., Huryn D.M., Chen X.S., Day B.W., Fidock D.A., Wipf P., and Brodsky J.L. Bioorg. Med. Chem. 17 (2009) 1527
13. Otvos L., Insug O., Rogers M., Consolvo P.J., Condie B.A., Lovas S., Bulet P., and Blaszczyk-Thurin M. Biochemistry 39 (2000) 14150
14. Mayer M.P., and Bukau B. Cell Mol. Life Sci. 62 (2005) 670
15. Han W., and Christen P. FEBS Lett. 563 (2004) 146
16. Han W., and Christen P. J. Biol. Chem. 278 (2003) 19038
17. Zhu X., Zhao X., Burkholder W.F., Gragerov A., Ogata C.M., Gottesman M.E., and Hendrickson W.A. Science 272 (1996) 1606
18. Kang Y., Taldone T., Clement C.C., Fewell S.W., Aguirre J., Brodsky J.L., and Chiosis G. Bioorg. Med. Chem. Lett. 18 (2008) 3749
19. Kabani M., Kelley S.S., Morrow M.W., Montgomery D.L., Sivendran R., Rose M.D., Gierasch L.M., and Brodsky J.L. Mol. Biol. Cell 14 (2003) 3437
20. Montgomery D.L., Morimoto R.I., and Gierasch L.M. J. Mol. Biol. 3 (1999) 915
21. Rudiger S., Germeroth L., Schneider-Mergener J., and Bukau B. EMBO J. 16 (1997) 1501
22. Dömling A., and Ugi I. Angew. Chem., Int. Ed. 39 (2000) 3168
23. Dömling A. Chem. Rev. 106 (2006) 17
24. Gerber P.R., and Muller J.K. Comput. Aided Mol. Design 9 (1995) 251
25. Sabot C., Kumar K.A., Meunier S., and Mioskowski C. Tetrahedron Lett. 48 (2007) 3863
26. Wang, W., Dömling, J. Comb. Chem., 2009, 11, doi:10.1021/cc9000136.
27. Goeckeler J.L., Petruso A.P., Aguirre J., Clement C.C., Chiosis G., and Brodsky J.L. FEBS Lett. 582 (2008) 2393