Nanodispersions of taxifolin: Impact of solid-state properties on dissolution behavior

International Journal of Pharmaceutics

Volumn 377, Issue 1-2, 2009, Pages 148-152

  Shikov, Alexander N ^a   Pozharitskaya, Olga N ^a   Miroshnyk, Inna ^b   Mirza, Sabiruddin ^b   Urakova, Irina N ^a   Hirsjärvi, Samuli ^b   Makarov, Valery G ^a   Heinämäki, Jyrki ^b   Yliruusi, Jouko ^b   Hiltunen, Raimo ^b  

^a Saint Petersburg Institute of Pharmacy   (Russian Federation)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Drug release kinetics; Lyophilization; Nanodispersion; Nanoparticles; Solid state properties; Taxifolin

Indexed keywords

NANOPARTICLE; POVIDONE; TAXIFOLIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STRUCTURE; IN VITRO STUDY; MICROSCOPY; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; SOLID STATE; STRUCTURE ANALYSIS; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; FREEZE DRYING; MOLECULAR STRUCTURE; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; POVIDONE; QUERCETIN; TECHNOLOGY, PHARMACEUTICAL;

EID: 67649644730     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.04.044     Document Type: Article

References (29)

1. Authelin J.-R. Thermodynamics of non-stoichiometric pharmaceutical hydrates. Int. J. Pharm. 303 (2005) 37-53
2. Buckton G., Adeniyi A., Saunders M., and Ambarkhane A. HyperDSC studies of amorphous polyvinylpyrrolidone in a model wet granulation system. Int. J. Pharm. 312 (2006) 61-65
3. Chiou W.L., and Riegelman S. Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci. 60 (1971) 1281-1302
4. Craig D.Q.M. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int. J. Pharm. 231 (2002) 131-144
5. Forster A., Rades T., and Hempenstall J. Selection of suitable drug and excipient candidates to prepare glass solutions by melt extrusion for immediate release oral formulations. Pharm. Technol. Eur. 14 (2002) 27-37
6. Gordon M., and Taylor J.S. Ideal copolymers and the second-order transitions of synthetic rubbers. I. Non-crystalline copolymers. J. Appl. Chem. 2 (1952) 493-500
7. In: Harborne B. (Ed). The Flavonoids, Advances in Research Since 1986 (1994), Chapman & Hall, London
8. Hollman P.C., and Katan M.B. Absorption, metabolism and health effects of dietary flavonoids in man. Biomed. Pharmacother. 51 (1997) 305-310
9. Karavas E., Georgarakis M., Docoslis A., and Bikiaris D. Combining SEM, TEM, and micro-Raman techniques to differentiate between the amorphous molecular level dispersions and nanodispersions of a poorly water-soluble drug within a polymer matrix. Int. J. Pharm. 340 (2007) 76-83
10. Landolfi R., Mower R.L., and Steiner M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem. Pharmacol. 33 (1984) 1525-1530
11. Leuner C., and Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm. 50 (2000) 47-60
12. Merisko-Liversidge E., Liversidge G.G., and Cooper E.R. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur. J. Pharm. Sci. 18 (2003) 113-120
13. Miller D.A., DiNunzio J.C., Yang W., McGinity J.W., and Williams III R.O. Targeted intestinal delivery of supersaturated itraconazole for improved oral absorption. Pharm. Res. 25 (2008) 1450-1459
14. Morris K. Structural aspect of hydrates and solvates. In: Britain H.G. (Ed). Polymorphism in Pharmaceutical Solids (1999), Marcel Dekker 125-226
15. Nijeveldt R.J., van Nood E., van Hoorn D.E.C., Boelens P.G., van Norren K., and van Leeuwen P.A.M. Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74 (2001) 418-425
16. Novoa G.A.G., Heinämäki J., Mirza S., Antikainen O., Iraizoz C.A., Suzarte P.A., and Yliruusi J. Physical solid-state properties and dissolution of sustained-release matrices of polyvinylacetate. Eur. J. Pharm. Biopharm. 59 (2005) 343-350
17. Nyamweya N., and Hoag S.W. Assessment of polymer-polymer interactions in blends of HPMC and film forming polymers by modulated temperature differential scanning calorimetry. Pharm. Res. 17 (2000) 625-631
18. Plotnikov M.B., Tjukavkina N.A., and Plotnikova T.M. Medicinal Preparations on the Base of Dihydroquerzetine (2005), Publishing house of Tomsk University, Tomsk
19. Pozharitskaya O.N., Vainshtein V.A., Strelkova L.F., and Kalinina N.A. Study of mechanism of dissolution of nifedipine from solid dispersion system with polyethylene glycol. Farmatsiia-Moskva 2 (1999) 18-20
20. Pozharitskaya O.N., Karlina M.V., Shikov A.N., Kosman V.M., Makarova M.N., and Makarov V.G. Determination and pharmacokinetic study of taxifolin in rabbit plasma by high-performance liquid chromatography. Phytomedicine 16 (2009) 244-251
21. Ruan L.P., Yu B.Y., Fu G.M., and Zhu D.N. Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. J. Pharm. Biomed. Anal. 38 (2005) 457-464
22. Shikov A.N., Pozharitskaya O.N., Miroshnyk I., Mirza S., Karlina M.V., Hirsjärvi S., Makarov V.G., Tikhonov V.P., and Hiltunen R. Nanosystems as a way of improving the bioavailability of natural compounds. Farmatsiia-Moskva 7 (2008) 53-57
23. Stahl P.H., and Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection and Use (2002), Wiley-VCH, Berlin
24. Stephenson A.G., Groleau E.G., Kleeman R.T., Xu W., and Rigsbee D.R. Formation of isomorphic desolvates: creating a molecular vacuum. J. Pharm. Sci. 87 (1998) 536-542
25. Stephenson G.A., and Diseroad D.A. Structural relationship and desolvation behavior of cromolyn disodium, cefazolin and fenoprofen sodium hydrates. Int. J. Pharm. 198 (2000) 177-200
26. Teselkin Yu.O., Babenkova I.V., Kolhir V.K., Baginskaya A.I., Tjukavkina N.A., Kolesnik Yu.A., Selivanova I.A., and Eichholz A.A. Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis. Phytother. Res. 14 (2000) 160-162
27. Tong P., and Zografi G. A study of amorphous molecular dispersions of indomethacin and its sodium salt. J. Pharm. Sci. 90 (2001) 1991-2004
28. Tzen S.H., Ko W., Ko F., and Teng C. Inhibition of platelet aggregation by some flavonoids. Thromb. Res. 64 (1991) 91-100
29. Van den Mooter G., Wuyts M., Blaton N., Busson R., Grobet P., Augustijns P., and Kinget R. Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrolidone K25. Eur. J. Pharm. Sci. 12 (2000) 261-269