Soluble HLA/peptide monomers cross-linked with co-stimulatory antibodies onto a streptavidin core molecule efficiently stimulate antigen-specific T cell responses

Cancer Immunology, Immunotherapy

Volumn 58, Issue 9, 2009, Pages 1459-1470

  Rusakiewicz, Sylvie ^a,c   Aubert, Geraldine ^a,d   Clark, Richard E ^b   Madrigal, Alejandro J ^a   Dodi, Anthony I ^a   Travers, Paul J ^a,e  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Antigen specific T cells activation; BCR ABL; HLA peptide co stimulatory antibody complexes; Human

Indexed keywords

CD 27 ANTIBODY; CD 28 ANTIBODY; CELL ANTIBODY; HLA A ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; STREPTAVIDIN; TETRAMER; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL DEATH; CELL ISOLATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXIC T LYMPHOCYTE; HLA SYSTEM; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD27; ANTIGENS, CD28; CELL PROLIFERATION; DENDRITIC CELLS; FLOW CYTOMETRY; FUSION PROTEINS, BCR-ABL; HLA-A ANTIGENS; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTES; PEPTIDE FRAGMENTS; STREPTAVIDIN; T-LYMPHOCYTES;

EID: 67649639120     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-009-0711-x     Document Type: Article

References (37)

1. JD Altman PA Moss PJ Goulder DH Barouch MG McHeyzer-Williams JI Bell AJ McMichael MM Davis 1996 Phenotypic analysis of antigen-specific T lymphocytes Science 274 5284 94 96 (Pubitemid 26332731)
2. SR Bennett FR Carbone F Karamalis RA Flavell JF Miller WR Heath 1998 Help for cytotoxic-T-cell responses is mediated by CD40 signalling Nature 393 6684 478 480
3. M Bocchia PA Wentworth S Southwood J Sidney K McGraw DA Scheinberg A Sette 1995 Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules Blood 85 10 2680 2684
4. M Bocchia T Korontsvit Q Xu S Mackinnon SY Yang A Sette DA Scheinberg 1996 Specific human cellular immunity to bcr-abl oncogene-derived peptides Blood 87 9 3587 3592 (Pubitemid 26129585)
5. JJ Boniface JD Rabinowitz C Wulfing J Hampl Z Reich JD Altman RM Kantor C Beeson HM McConnell MM Davis 1998 Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected] Immunity 9 4 459 466 (Pubitemid 28499197)
6. A Buzyn M Ostankovitch A Zerbib M Kemula F Connan B Varet JG Guillet J Choppin 1997 Peptides derived from the whole sequence of BCR-ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytes Eur J Immunol 27 8 2066 2072 (Pubitemid 27346025)
7. JL Cannons P Lau B Ghumman MA DeBenedette H Yagita K Okumura TH Watts 2001 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy J Immunol 167 3 1313 1324 (Pubitemid 32703127)
8. M Cebecauer P Guillaume P Hozak S Mark H Everett P Schneider IF Luescher 2005 Soluble MHC-peptide complexes induce rapid death of CD8+ CTL J Immunol 174 11 6809 6819
9. RE Clark IA Dodi SC Hill JR Lill G Aubert AR Macintyre J Rojas A Bourdon PL Bonner L Wang SE Christmas PJ Travers CS Creaser RC Rees JA Madrigal 2001 Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein Blood 98 10 2887 2893
10. B Couderc L Zitvogel V Douin-Echinard L Djennane H Tahara G Favre MT Lotze PD Robbins 1998 Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells Cancer Gene Ther 5 3 163 175 (Pubitemid 128640003)
11. J Dal Porto TE Johansen B Catipovic DJ Parfiit D Tuveson U Gether S Kozlowski DT Fearon JP Schneck 1993 A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations Proc Natl Acad Sci USA 90 14 6671 6675
12. L Diehl AT den Boer SP Schoenberger EI van der Voort TN Schumacher CJ Melief R Offringa RE Toes 1999 CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy Nat Med 5 7 774 779 (Pubitemid 29318611)
13. JF Fonteneau M Larsson S Somersan C Sanders C Munz WW Kwok N Bhardwaj F Jotereau 2001 Generation of high quantities of viral and tumor-specific human CD4+ and CD8+ T-cell clones using peptide pulsed mature dendritic cells J Immunol Methods 258 1-2 111 126 (Pubitemid 33016531)
14. RR French HT Chan AL Tutt MJ Glennie 1999 CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help Nat Med 5 5 548 553 (Pubitemid 29220214)
15. C Guelly Z Kupcu D Zalusky M Karner M Zehetner T Schweighoffer 2002 Activation requirements of circulating antigen-specific human CD8(+) memory T cells probed with insect cell-based artificial antigen-presenting cells Eur J Immunol 32 1 182 192 (Pubitemid 34092836)
16. RQ Hintzen SM Lens K Lammers H Kuiper MP Beckmann RA van Lier 1995 Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation J Immunol 154 6 2612 2623
17. JC Hurtado YJ Kim BS Kwon 1997 Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death J Immunol 158 6 2600 2609 (Pubitemid 127470516)
18. JB Latouche M Sadelain 2000 Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells Nat Biotechnol 18 4 405 409 (Pubitemid 30217527)
19. Li J, Bowen G, Murphy JJ, Davies H, Hollingsworth S, Mufti G (1997) Induction of human T cell responses to tumour-associated neoantigens and virus antigens using cultured dendritic cells. Biochem Soc Trans 25(2): 204S (Pubitemid 27260964)
20. MG Lorenz JA Kantor J Schlom JW Hodge 1999 Anti-tumor immunity elicited by a recombinant vaccinia virus expressing CD70 (CD27L) Hum Gene Ther 10 7 1095 1103 (Pubitemid 29231854)
21. R Maile B Wang W Schooler A Meyer EJ Collins JA Frelinger 2001 Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers J Immunol 167 7 3708 3714 (Pubitemid 32910815)
22. MV Maus JL Riley WW Kwok GT Nepom CH June 2003 HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells Clin Immunol 106 1 16 22 (Pubitemid 36263297)
23. MV Maus AK Thomas DG Leonard D Allman K Addya K Schlienger JL Riley CH June 2002 Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB Nat Biotechnol 20 2 143 148 (Pubitemid 34158029)
24. M Nieda A Nicol A Kikuchi K Kashiwase K Taylor K Suzuki K Tadokoro T Juji 1998 Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia Blood 91 3 977 983 (Pubitemid 28078301)
25. SM O'Herrin JE Slansky Q Tang MA Markiewicz TF Gajewski DM Pardoll JP Schneck JA Bluestone 2001 Antigen-specific blockade of T cells in vivo using dimeric MHC peptide J Immunol 167 5 2555 2560 (Pubitemid 32768882)
26. M Oelke MV Maus D Didiano CH June A Mackensen JP Schneck 2003 Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells Nat Med 9 5 619 624 (Pubitemid 36597110)
27. M Oelke U Moehrle JL Chen D Behringer V Cerundolo A Lindemann A Mackensen 2000 Generation and purification of CD8+ melan-A-specific cytotoxic T lymphocytes for adoptive transfer in tumor immunotherapy Clin Cancer Res 6 5 1997 2005 (Pubitemid 30306176)
28. LE Oosten E Blokland AG van Halteren J Curtsinger MF Mescher JH Falkenburg T Mutis E Goulmy 2004 Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes Blood 104 1 224 226 (Pubitemid 38879861)
29. Y Osman M Takahashi Z Zheng T Koike K Toba A Liu T Furukawa S Aoki Y Aizawa 1999 Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients Leukemia 13 2 166 174 (Pubitemid 29092648)
30. GA Papanicolaou JB Latouche C Tan J Dupont J Stiles EG Pamer M Sadelain 2003 Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele Blood 102 7 2498 2505 (Pubitemid 37193588)
31. EF Posthuma CA van Bergen MG Kester RA de Paus PA van Veelen AH de Ru JW Drijfhout EG Lurvink R Willemze JH Falkenburg 2004 Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated Haematologica 89 9 1062 1071 (Pubitemid 39295477)
32. Schilbach K, Kerst G, Walter S, Eyrich M, Wernet D, Handgretinger R, Xie W, Rammensee HG, Muller I, Buhring HJ, Niethammer D (2005) Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction. Blood 106(1):144-149 (Pubitemid 40967186)
33. SP Schoenberger RE Toes EI van der Voort R Offringa CJ Melief 1998 T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions Nature 393 6684 480 483
34. WW Shuford K Klussman DD Tritchler DT Loo J Chalupny AW Siadak TJ Brown J Emswiler H Raecho CP Larsen TC Pearson JA Ledbetter A Aruffo RS Mittler 1997 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses J Exp Med 186 1 47 55 (Pubitemid 27304846)
35. A Solache CL Morgan AI Dodi C Morte I Scott C Baboonian B Zal J Goldman JE Grundy JA Madrigal 1999 Identification of three HLA-A*0201-restricted cytotoxic T cell epitopes in the cytomegalovirus protein pp65 that are conserved between eight strains of the virus J Immunol 163 10 5512 5518
36. S Walter L Herrgen O Schoor G Jung D Wernet HJ Buhring HG Rammensee S Stevanovic 2003 Cutting edge: predetermined avidity of human CD8 T cells expanded on calibrated MHC/anti-CD28-coated microspheres J Immunol 171 10 4974 4978 (Pubitemid 37432775)
37. MR Wills AJ Carmichael K Mynard X Jin MP Weekes B Plachter JG Sissons 1996 The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL J Virol 70 11 7569 7579 (Pubitemid 26340108)