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Xu F, Gee JM, Naleway A, et al. Incidence of neonatal herpes simplex virus infections in two managed care organizations: implications for surveillance. Sex Transm Dis 2008; 35:592-598. Case definition of NHSV very close to that proposed by CDC subcommittee in March 2007. Algorithmic approach to case and probable case, a model for healthcare organizations to use for NHSV incidence assessment.
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Xu F, Markowitz LE, Gottlieb SL, Berman SM. Seroprevalence of herpes simplex virus types 1 and 2 in pregnant women in the United States. Am J Obstet Gynecol 2007; 196:e43e1-e43e6. Current seroprevalence of HSV-1 and 2 at 63 and 22% in female population aged 15-41 years is important information to the obstetrician and gynecologist.
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Xu F, Markowitz LE, Gottlieb SL, Berman SM. Seroprevalence of herpes simplex virus types 1 and 2 in pregnant women in the United States. Am J Obstet Gynecol 2007; 196:e43e1-e43e6. Current seroprevalence of HSV-1 and 2 at 63 and 22% in female population aged 15-41 years is important information to the obstetrician and gynecologist.
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13
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Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students
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14
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Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
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Demonstrates absence of protective effect of HSV-1 antibodies on HSV-2 vertical transmission
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Brown EL, Gardella C, Malm G, et al. Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes. Acta Obstet Gynecol 2007; 86:523-529. Demonstrates absence of protective effect of HSV-1 antibodies on HSV-2 vertical transmission.
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Kroop RY, Wong T, Cormier L, et al. Neonatal herpes simplex virus infections in Canada: results of a 3-year national prospective study. Pediatrics 2006; 117:1955-1962.
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Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians
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Provides cogent understanding of argument for maternal HSV screening
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Gardella C, Barnes J, Margaret AS, et al. Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians. Obstet Gynecol 2007; 110:1364-1370. Provides cogent understanding of argument for maternal HSV screening.
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Tita ATN, Grobman WA, Rouse DJ. Antenatal herpes serologic screening: an appraisal of the evidence. Obstet Gynecol 2006; 108:1247-1253.
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18
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Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
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Could not be more thought provoking than these investigators' findings of more frequent HSV reactivation than previously believed and its implications for permissive HIV infection, and potential subtherapeutic levels of viral suppression in pregnancy
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Mark KE, Wald A, Magaret AS, et al. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis 2008; 198:1141-1149. Could not be more thought provoking than these investigators' findings of more frequent HSV reactivation than previously believed and its implications for permissive HIV infection, and potential subtherapeutic levels of viral suppression in pregnancy.
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Cherpes TL, Melan JA, Kant L, et al. Genital tract shedding of herpes simplex virus type 2 in women: effects of hormonal contraception, bacterial vaginosis, and vaginal group B Streptococcus colonization. Clin Infect Dis 2005; 40:1422-1428.
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+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation
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+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation. J Immunol 2008; 181:969-975.
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Caviness CA, Demmler GJ, Selvyn BJ. Clinical and laboratory features of neonatal herpes simplex virus infection. A case-control study. Pediatr Infect Dis J 2008; 27:425-430.
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Is the current strategy for NHSV as advocated by the AAP correct? Should more utilitarian methodology be employed
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Caviness AC, Demmler GJ, Swint JM, Cantor SB. Cost-effectiveness analysis of herpes simplex virus testing and treatment strategies in febrile neonates. Arch Pediatr Adolesc Med 2008; 162:665-674. Is the current strategy for NHSV as advocated by the AAP correct? Should more utilitarian methodology be employed?
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A basic scientific understanding of how genital HSV might be permissive for HIV-1 transmission
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Sheffield JS, Wendel GD, McIntire DD, Norgard MV. Effect of genital ulcer disease on HIV-1 co receptor expression in the female genital tract. J Infect Dis 2007; 196:1509-1516. A basic scientific understanding of how genital HSV might be permissive for HIV-1 transmission.
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Sheffield, J.S.1
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30
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Provides observational evidence of the permissive role of maternal HSV in HIV-1 transmission
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Cowan FM, Humphrey JH, Ntozini R, et al. Maternal herpes simplex virus type 2 infection, syphilis and risk of intra-partum transmission of HIV-1: results of a case control study. AIDS 2008; 22:193-201. Provides observational evidence of the permissive role of maternal HSV in HIV-1 transmission.
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Cowan, F.M.1
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Gray RH, Wabwire-Mangen F, Kigozi G, et al. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. Am J Obstet Gynecol 2005; 185:1209-1217.
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Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
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This trial provides evidence of reduction of HIV-1 RNA in the genital tract and maternal serum with valacyclovir treatment
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Nagot N, Ouedrago A, Foulongne V, et al. Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. N Engl J Med 2007; 356: 790-799. This trial provides evidence of reduction of HIV-1 RNA in the genital tract and maternal serum with valacyclovir treatment.
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Nagot, N.1
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Tuomala RE, O'Driscoll PT, Brerner JW, et al. Cell-associated genital tract virus and vertical transmission of human immunodeficiency virus type 1 in antiretroviral-experienced women. J Infect Dis 2003; 187: 375-384.
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Watson-Jones D, Weiss HA, Rusizoka M, et al. Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med 2008; 358:1560-1571. The first trial to examine the efficacy of reduction in HIV-1 horizontal transmission with antisuppressive acyclovir therapy in an HIV-1 and HSV-2-prevalent population. Unfortunately, no effect of acyclovir antisuppressive therapy was found.
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Watson-Jones D, Weiss HA, Rusizoka M, et al. Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med 2008; 358:1560-1571. The first trial to examine the efficacy of reduction in HIV-1 horizontal transmission with antisuppressive acyclovir therapy in an HIV-1 and HSV-2-prevalent population. Unfortunately, no effect of acyclovir antisuppressive therapy was found.
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35
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Sheffield JS, Hill JB, Hollier LM, et al. Valacyclovir prophylaxis to prevent recurrent herpes at delivery. A randomized clinical trial. ObstetGynecol 2006; 108:141-147.
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36
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ACOG Practice Bulletin No. 82. American College of Obstetricians and Gynecologists. Management of herpes in pregnancy
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The current recommendations from ACOG are extensive and informative and easily understood. They are also very up-to-date. ACOG Committee on Practice Bulletins
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ACOG Committee on Practice Bulletins. ACOG Practice Bulletin No. 82. American College of Obstetricians and Gynecologists. Management of herpes in pregnancy. Obstet Gynecol 2007; 109:1489-1498. The current recommendations from ACOG are extensive and informative and easily understood. They are also very up-to-date.
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Management of genital herpes in pregnancy. Green-top Guideline No. 30. Royal College of Obstetricians and Gynaecologists. September 2007. Everyone might not think so, but the recommendations from Royal College of Obstetricians and Gynaecologists (RCOG) are an interesting contrast to ACOG in understanding management of maternal HSV in developed nations.
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Management of genital herpes in pregnancy. Green-top Guideline No. 30. Royal College of Obstetricians and Gynaecologists. September 2007. Everyone might not think so, but the recommendations from Royal College of Obstetricians and Gynaecologists (RCOG) are an interesting contrast to ACOG in understanding management of maternal HSV in developed nations.
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