Steroid-free immunosuppression in pediatric renal transplantation: Rationale outcomes following conversion to steroid based therapy

Transplantation

Volumn 87, Issue 11, 2009, Pages 1744-1748

  Sutherland, Scott ^a   Li, Li ^a   Concepcion, Waldo ^b   Salvatierra, Oscar ^b   Sarwal, Minnie M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Glomerulonephritis; Renal transplantation; Steroid free

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; DACLIZUMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS;

ACUTE GRAFT REJECTION; ALLOGRAFT; ARTICLE; CHILD; CLINICAL PROTOCOL; DRUG SUBSTITUTION; FEMALE; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT FAILURE; TREATMENT INDICATION;

ADOLESCENT; ADRENAL CORTEX HORMONES; BIOPSY; CADAVER; CHILD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; RECURRENCE; RETROSPECTIVE STUDIES; TIME FACTORS; TISSUE DONORS; TREATMENT OUTCOME;

EID: 67649574146     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181a5df60     Document Type: Article

References (28)

1. Delucchi A, Valenzuela M, Ferrario M, et al. Early steroid withdrawal in pediatric renal transplant on newer immunosuppressive drugs. Pediatr Transplant 2007; 11: 743.
2. Sarwal MM, Yorgin PD, Alexander S, et al. Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. Transplantation 2001; 72: 13.
3. Ibrahim H, Rogers T, Casingal V, et al. Graft loss from recurrent glomerulonephritis is not increased with a rapid steroid discontinuation protocol. Transplantation 2006; 81: 214.
4. Matas AJ, Kandaswamy R, Gillingham KJ, et al. Prednisone-free maintenance immunosuppression-A 5-year experience. Am J Transplant2005; 5: 2473.
5. Fine RN, Ho M, Tejani A. The contribution of renal transplantation to final adult height: A report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Pediatr Nephrol 2001; 16: 951.
6. Vidhun JR, Sarwal MM. Corticosteroid avoidance in pediatric renal transplantation. Pediatr Nephrol 2005; 20: 418.
7. Pascual J, Quereda C, Zamora J, et al. Steroid withdrawal in renal transplant patients on triple therapy with a calcineurin inhibitor and mycophenolate mofetil: A meta-analysis of randomized, controlled trials. Transplantation 2004; 78: 1548.
8. Tönshoff B, Höcker B, Weber LT. Steroid withdrawal in pediatric and adult renal transplant recipients. Pediatr Nephrol 2005; 20: 409.
9. Vincenti F, Schena FP, Paraskevas S, et al. A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients. Am J Transplant 2008; 8: 307.
10. Höcker B, John U, Plank C, et al. Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: Results after four years. Transplantation2004; 78: 228.
11. Birkeland SA. Steroid-free immunosuppression in renal transplantation: A long-term follow-up of 100 consecutive patients. Transplantation2001; 71: 1089.
12. Khwaja K, Asolati M, Harmon J, et al. Outcome at 3 years with a prednisone-free maintenance regimen: A single-center experience with 349 kidney transplant recipients. Am J Transplant 2004; 4: 980.
13. ter Meulen CG, van Riemsdijk I, Hene' RJ, et al. Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: A prospective, randomized, multicenter study. Am J Transplant2004; 4: 803.
14. Kumar MS, Heifets M, Moritz MJ, et al. Safety and efficacy of steroid withdrawal two days after kidney transplantation: Analysis of results at three years. Transplantation 2006; 81: 832.
15. SarwalMM,VidhunJR, Alexander SR, et al. Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation. Transplantation 2003; 76: 1331.
16. Gallon L, Perico N, Dimitrov BD, et al. Long-term renal allograft function on a tacrolimus-based, pred-free maintenance immunosuppression comparing sirolimus vs. MMF. Am J Transplant 2006; 6: 1617.
17. Kaufman DB, Leventhal JR, Axelrod D, et al. Alemtuzumab induction and prednisone-free maintenance immunotherapy in kidney transplantation: Comparison with basiliximab induction-Long-term results. Am J Transplant 2005; 5: 2539.
18. Ellis D, Shapiro R, Moritz M, et al. Renal transplantation in children managed with lymphocyte depleting agents and low-dose maintenance tacrolimus monotherapy. Transplantation 2007; 83: 1563.
19. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
20. Schwartz GJ, Haycock GB, Edelmann CM, et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259.
21. Kandaswamy R, Melancon JK, Dunn T, et al. A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients-An interim analysis. Am J Transplant 2005; 5: 1529.
22. Troppmann C, Gillingham KJ, Benedetti E, et al. Delayed graft function, acute rejection, and outcome after cadaver renal transplantation. The multivariate analysis. Transplantation 1995; 59: 962.
23. Matas AJ. Impact of acute rejection on development of chronic rejection in pediatric renal transplant recipients. Pediatr Transplant2000; 4: 92.
24. Cosio FG, Pelletier RP, Falkenhain ME, et al. Impact of acute rejection and early allograft function on renal allograft survival. Transplantation1997; 63: 1611.
25. Briganti EM, Russ GR, McNeil JJ, et al. Risk of renal allograft loss from recurrent glomerulonephritis. N Eng J Med 2002; 347: 103.
26. Choy BY, Chan TM, Lai KN. Recurrent glomerulonephritis after kidney transplantation. Am J Transplant 2006; 6: 2535.
27. Humar A, Gillingham K, Kandaswamy R, et al. Steroid avoidance regimens: A comparison of outcomes with maintenance steroids versus continued steroid avoidance in recipients having an acute rejection episode. Am J Transplant 2007; 7: 1948.
28. Matas AJ. Recurrent disease after kidney transplantation-It is time to unite to address this problem! Am J Transplant 2006; 6: 2527.