Emblica officinalis protects against alcohol-induced liver mitochondrial dysfunction in rats

Journal of Medicinal Food

Volumn 12, Issue 2, 2009, Pages 327-333

  Damodara Reddy, V ^a   Padmavathi, P ^a   Varadacharyulu, N Ch ^a  

^a SRI KRISHNADEVARAYA UNIVERSITY   (India)

Author keywords

Alcohol; Emblica officinalis; Liver mitochondria; Nitric oxide; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME C OXIDASE; EMBLICA OFFICINALIS EXTRACT; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; EMBLICA OFFICINALIS; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER DYSFUNCTION; LIVER INJURY; LIVER MITOCHONDRION; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RAT;

ANIMALS; ANTIOXIDANTS; ETHANOL; FRUIT; LIPID PEROXIDATION; LIVER DISEASES; MALE; MITOCHONDRIA, LIVER; NITRIC OXIDE; PHYLLANTHUS EMBLICA; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN CARBONYLATION; RATS; RATS, WISTAR;

PHYLLANTHUS EMBLICA; RATTUS;

EID: 67649556146     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2007.0694     Document Type: Article

References (46)

1. Yan M, Zhu P, Liu HM, Zhang HT, Liu L: Ethanol induced mitochondria injury and permeability transition pore opening: role of mitochondria in alcoholic liver disease. World J Gastroenterol 2007;13:2352-2356.
2. Lee JS: Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clin Chim Acta 2006;347:121-128.
3. Lieber CS: Metabolic effects of acetaldehyde. Biochem Soc Trans 1988;16:241-247.
4. Dey A, Cederbaum AI: Alcohol and oxidative liver injury. Hepatology 2006;43(Suppl):S63-S74.
5. Venkatraman A, Shiva S, Wigley A, Ulasova E, Shhieng D, Bailey SM, Darley-Usmar VM: The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. Hepatology 2004;40:565-573.
6. Albano E: Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 2006;65:278-290.
7. Zhou JF, Cai DD, Zhu YG, Yang JL, Peng CH, Yu YH: A study on relationship of nitric oxide, oxidation, per oxidation, lipoper-oxidation with chronic cholecystitis. World J Gastroenterol 2000; 6:501-507.
8. Pacher P, Beckman JS, Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev 2007;87:315-424.
9. Xu BJ, Zheng YN, Sung CK: Natural medicines for alcoholism treatment: a review. Drug Alcohol Rev 2005;24:525-536.
10. Sebastian T, Setty OH: Protective effect of P. fraternus against ethanol-induced mitochondrial dysfunction. Alcohol 1999;17: 29-34.
11. 4 induced hepatic toxicity and DNA synthesis in wistar rats. Indian J Exp Biol 2005;43:430-436.
12. Scartezzini P, Antognoni F, Raggi MA, Poli F, Sabbioni C: Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation Emblica officinalis Gaertn. J Ethnopharmacol 2006;104:113-118.
13. Jose JK, Kuttan R: Hepatoprotective activity of Emblica officinalis and Chyavanaprash. J Ethnopharmacol 2000;72:135-140.
14. Reitman S, Frankel S: A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 1957;28:8-15.
15. Teitz RW: Fundamentals of Clinical Chemistry. W.B. Saunders, Philadelphia, 1976, pp. 602-603.
16. Rosalki SB, Tarlow D: Optimized determination of γ-glutamyl transferase by reaction-rate analysis. Clin Chem 1974;20:1121-1124.
17. Laurence CB, Davies NT: A novel, simple and rapid method for the isolation of mitochondria which exhibit respiratory control, from rat small intestinal mucosa. Biochim Biophys Acta 1986;848:35-40.
18. Sastry KVH, Moudgal RP, Mohan J, Tyagi JS, Rao GS: Spec-trophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal Biochem 2002;306:79-82.
19. Mishra PH, Fridovich I: The role of superoxide anion in the au-toxidation of epinephrine and a simple assay for superoxide dis-mutase. J Biol Chem 1972;247:3170-3175.
20. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG: Selenium: biochemical role as a component of glu-tathione peroxidase. Science 1973;179:588-590.
21. Ellman GL: Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-77.
22. King TE: Preparation of succinate dehydrogenase and reconsti-tution of succinate oxidase. Methods Enzymol 1967;10:322-331.
23. Cooperstein SJ, Lazarow A: A microspectrophotometric method for the determination of cytochrome oxidase. J Biol Chem 1951; 189:665-670.
24. King TE, Howard RL: Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol 1967;10:322-331.
25. 1 and c in mitochondria. Arch Biochem Biophys 1964;107:537-543.
26. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358.
27. Reznick AZ, Packer L: Oxidative damage to proteins: spectro-scopic method for carbonyl assay. Methods Enzymol 1994;233: 357-363.
28. Lowry OH, Rosebrough NJ, Farr AL, Randall R: Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:263-275.
29. Bennet CA, Franklin NL: Statistical Analysis of Chemistry and the Chemical Industry. John Wiley and Sons, London, 1967, pp. 208-227.
30. Rajagopal S, Manickam P, Periyasamy V, Namasivayam N: Activity of Casia auriculata leaf extract in rats with alcoholic liver injury. J Nutr Biochem 2003;14:452-458.
31. Sheela CG, Augusti KT: Antiperoxide effects of S-allyl cys-teine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats. Indian J Exp Biol 1995;33:337-340.
32. Reedy AC, Lokesh BR: Studies on apice principle as an antioxi-dant in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem 1992;111:117-124.
33. Gueeri H: Influence on prolonged ethanol intake on the level and turnover of alcohol and aldehyde dehydrogenase and glutathione. Adv Exp Med Biol 1995;23:12-14.
34. Bhattacharya A, Ghosal S, Bhattacharya SK: Antioxidant activity of tannoid principles of Emblica officinalis (amla) in chronic stress induced changes in rat brain. Indian J Exp Biol 2000;38: 877-880.
35. Berlett BS, Stadtman ER: Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 1997;272:20313-20316.
36. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC: Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res 2001;25:726-733.
37. Wu D, Cederbaum AI: Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 2003;27:277-284.
38. Thampi HBS, Manoj G, Leelamma S, Menon VP: Dietary fiber and lipid peroxidation. Effects of dietary fiber on levels of lipids and lipid peroxides in high fat diet. Indian J Exp Biol 1991;29: 563-567.
39. Joshi MS, Ponthier JL, Lancaster JR: Cellular antioxidant and pro-oxidant actions of nitric oxide. Free Radic Biol Med 1999;27: 1357-1366.
40. Quijano C, Romero N, Radi R: Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic Biol Med 2005;39:728-741.
41. Bernstein JD, Penniall R: Effect of chronic ethanol treatment upon rat liver mitochondria. Biochem Pharmacol 1978;27:2337- 2342.
42. Brown GC: Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 2001;1504:46-57.
43. Thayer WS, Rubin E: Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption. J Biol Chem 1981;256:6090-6097.
44. Paradies G, Ruggiero FM, Petrosillo G, Quagliatiello E: Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats. Biochim Biophys Acta 1994;1225:165-170.
45. Thayer WS, Rubin E: Effects of chronic ethanol consumption on the respiratory chain of rat liver submitochondrial particles. Adv Exp Med Biol 1980;132:385-392.
46. Kumaran A, Karunakaran RJ: Nitric oxide radical scavenging active components from Phyllanthus emblica L. Plant Foods Hum Nutr 2006;61:1-5.