CD27 in defining memory B-cell origins in Waldenström's macroglobulinemia

Clinical Lymphoma and Myeloma

Volumn 9, Issue 1, 2009, Pages 33-35

  Sahota, Surinder ^a   Babbage, Gavin ^a   Weston Bell, Nicola ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

CD70; Somatic hypermutation; V genes; Waldenstr m

Indexed keywords

CD27 ANTIGEN; CD70 ANTIGEN; COMPLEMENTARY DNA; CYTIDINE DEAMINASE; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MULTIDRUG RESISTANCE PROTEIN 1;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CELL STRUCTURE; CELL SUBPOPULATION; CHROMOSOME TRANSLOCATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE SWITCHING; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GERMINAL CENTER; GLYCOSYLATION; HAIRY CELL LEUKEMIA; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; INNATE IMMUNITY; MEMORY CELL; MULTIPLE MYELOMA; PATHOGENESIS; PLASMA CELL; PROGENY; SIGNAL TRANSDUCTION; SOMATIC HYPERMUTATION; WALDENSTROEM MACROGLOBULINEMIA; B LYMPHOCYTE; BIOSYNTHESIS; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY;

ANTIGENS, CD27; B-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; WALDENSTROM MACROGLOBULINEMIA;

EID: 67649522710     PISSN: 15579190     EISSN: None     Source Type: Journal    
DOI: 10.3816/CLM.2009.n.007     Document Type: Article

References (28)

1. Berek C. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol Rev 1992; 126:5-19.
2. Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102:553-63.
3. Kobata T, Jacquot S, Kozlowski S, et al. CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci U S A 1995; 92:11249-53.
4. Klein U, Tu Y, Stolovitzky GA, et al. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci U S A 2003; 100:2639-44.
5. Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998; 188:1679-89.
6. Weller S, Braun MC, Tan BK, et al. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004; 104:3647-54.
7. Stevenson FK, Sahota SS, Ottensmeier CH, et al. The occurrence and significance of V gene mutations in B cell-derived human malignancy. Adv Cancer Res 2001; 83:81-116.
8. Radcliffe CM, Arnold JN, Suter DM, et al. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. J Biol Chem 2007; 282:7405-15
9. Kriangkum J, Taylor BJ, Treon SP, et al. Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood. Blood 2004; 104:2134-42.
10. Babbage G, Townsend M, Zojer N, et al. IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo. Leukemia 2007; 21:827-30.
11. Forconi F, Raspadori D, Lenoci M, et al. Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies. Haematologica 2005; 90:266-8.
12. Forconi F, Sozzi E, Rossi D, et al. Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia. Haematologica 2008; 93:697-705.
13. Sahota SS, Forconi F, Ottensmeier CH, et al. Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood 2002; 100:1505-7.
14. Walsh SH, Laurell A, Sundström G, et al. Lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia derives from an extensively hypermutated B cell that lacks ongoing somatic hypermutation. Leuk Res 2005; 29:729-34.
15. Martn-Jiménez P, Garca-Sanz R, Balanzategui A, et al. Molecular characterization of heavy chain immunoglobulin gene rearrangements in Waldenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Haematologica 2007; 92:635-42.
16. Stone MJ, Merlini G, Pascual V. Autoantibody activity in Waldenstrom's macroglobulinemia. Clin Lymphoma 2005; 5:225-9.
17. Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood 2004; 103:4389-95.
18. Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 2004; 64:1546-58.
19. Schop RF, Kuehl WM, Van Wier SA, et al. Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions. Blood 2002; 100:2996-3001.
20. McCann KJ, Johnson PW, Stevenson FK, et al. Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event? Leukemia 2006; 20:530-4.
21. Zhu D, McCarthy H, Ottensmeier CH, et al. Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 2002; 99:2562-8.
22. Wirths S, Lanzavecchia A. ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells. Eur J Immunol 2005; 35:3433-41.
23. Wei C, Anolik J, Cappione A, et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol 2007; 178:6624-33.
24. Fecteau JF, Côté G, Néron S. A new memory CD27-IgG+ B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation. J Immunol 2006; 177:3728-36.
25. Scheeren FA, Nagasawa M, Weijer K, et al. T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med 2008; 205:2033-42.
26. Forconi F, Sahota SS, Raspadori D, et al. Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch. Blood 2004; 104:3312-7.
27. Ho AW, Hatjiharissi E, Ciccarelli BT, et al. CD27-CD70 interactions in the pathogenesis of Waldenstrom's Macroglobulinemia. Blood 2008; 112:4683-9.
28. Takizawa M, Tolarov H, Li Z, et al. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med 2008; 205:1949-57.