Punicic acid from Trichosanthes kirilowii seed oil is rapidly metabolized to conjugated linoleic acid in rats

Journal of Medicinal Food

Volumn 12, Issue 2, 2009, Pages 416-422

  Yuan, Gao Feng ^a,b   Yuan, Jing Qun ^a   Li, Duo ^a,b,c  

^a ZHEJIANG UNIVERSITY   (China)

^b APCNS Centre of Nutrition and Food Safety   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

eleostearic acid; Conjugated linoleic acid; Conjugated linolenic acid; Trichosanthes kirilowii Maxim

Indexed keywords

CONJUGATED LINOLEIC ACID; PUNICIC ACID; TRICHOSANTHES EXTRACT; UNCLASSIFIED DRUG; VEGETABLE OIL;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG ACTIVITY; FATTY ACID BLOOD LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIVER; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; TRICHOSANTHES;

ANIMALS; LINOLEIC ACIDS, CONJUGATED; LINOLENIC ACIDS; MALE; PLANT EXTRACTS; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; SEEDS; TISSUE DISTRIBUTION; TRICHOSANTHES;

RATTUS; TRICHOSANTHES KIRILOWII;

EID: 67649497094     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2007.0541     Document Type: Article

References (30)

1. Iwabuchi M, Kohno-Murase J, Imamura J: Delta 12-oleate desaturase-related enzymes associated with formation of conjugated trans-delta 11, cis-delta 13 double bonds. J Biol Chem 2003;278:4603-4610.
2. Salas-Salvado J, Marquez-Sandoval F, Bullo M: Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 2006;46:479-488.
3. Park Y, Pariza MW: Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Res Int 2007;40:311-323.
4. Lee KW, Lee HJ, Cho HY, Kim YJ: Role of the conjugated linoleic acid in the prevention of cancer. Crit Rev Food Sci Nutr 2005;45:135-144.
5. Suzuki R, Noguchi R, Ota T, Abe M, Miyashita K, Kawada T: Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells. Lipids 2001; 36:477-482.
6. Igarashi M, Miyazawa T: Preparation and fractionation of conjugated trienes from alpha-linolenic acid and their growth-inhibitory effects on human tumor cells and fibroblasts. Lipids 2005;40: 109-113.
7. Yasui Y, Hosokawa M, Sahara T, Suzuki R, Ohgiya S, Kohno H, Tanaka T, Miyashita K: Bitter gourd seed fatty acid rich in 9c, 11t, 13t-conjugated linolenic acid induces apoptosis and up-reg-ulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 2005;73:113-119.
8. Tsuzuki T, Tokuyama Y, Igarashi M, Miyazawa T: Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogene-sis 2004;25:1417-1425.
9. Kohno H, Suzuki R, Noguchi R, Hosokawa M, Miyashita K, Tanaka T: Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Jpn J Cancer Res 2002;93:133-142.
10. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T: Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci 2004;95:481-486.
11. Yamasaki M, Kitagawa T, Koyanagi N, Chujo H, Maeda H, Kohno-Murase J, Imamura J, Tachibana H, Yamada K: Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice. Nutrition 2006;22:54-59.
12. Noguchi R, Yasui Y, Suzuki R, Hosokawa M, Fukunaga K, Miyashita K: Dietary effects of bitter gourd oil on blood and liver lipids of rats. Arch Biochem Biophys 2001;396:207-212.
13. Koba K, Imamura J, Akashoshi A, Kohno-Murase J, Nishizono S, Iwabuchi M, Tanaka K, Sugano M: Genetically modified rape-seed oil containing cis-9,trans-11,cis-13-octadecatrienoic acid affects body fat mass and lipid metabolism in mice. J Agric Food Chem 2007;55:3741-3748.
14. Arao K, Wang YM, Inoue N, Hirata J, Cha JY, Nagao K, Yanagita T: Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hy-perlipidemic OLETF rats. Lipids Health Dis 2004;3:24.
15. Banni S, Petroni A, Blasevich M, Carta G, Cordeddu L, Murru E, Melis MP, Mahon A, Belury MA: Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA. Lipids 2004;39:1143-1146.
16. Fa M, Diana A, Carta G, Cordeddu L, Melis MP, Murru E, So-gos V, Banni S: Incorporation and metabolism of c9,t11 and t10,c12 conjugated linoleic acid (CLA) isomers in rat brain. Biochim Biophys Acta 2005;1736:61-66.
17. Tsuzuki T, Igarashi M, Komai M, Miyazawa T: The metabolic conversion of 9,11,13-eleostearic acid (18:3) to 9,11-conjugated linoleic acid (18:2) in the rat. J Nutr Sci Vitaminol (Tokyo) 2003;49:195-200.
18. Tsuzuki T, Tokuyama Y, Igarashi M, Nakagawa K, Ohsaki Y, Komai M, Miyazawa T: Alpha-eleostearic acid (9Z11E13E-18:3) is quickly converted to conjugated linoleic acid (9Z11E-18:2) in rats. J Nutr 2004;134:2634-2639.
19. Tsuzuki T, Kawakami Y, Abe R, Nakagawa K, Koba K, Imamura J, Iwata T, Ikeda I, Miyazawa T: Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. J Nutr 2006;136:2153-2159.
20. Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachan-dran C, Rabi T, Kaplan B, Lansky E: Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71: 203-217.
21. Hora JJ, Maydew ER, Lansky EP, Dwivedi C: Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food 2003;6:157-161.
22. Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ: Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food 2004;7:274-283.
23. Jeune MA, Kumi-Diaka J, Brown J: Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J Med Food 2005;8:469-475.
24. Lansky EP, Harrison G, Froom P, Jiang WG: Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Ma-trigel. Invest New Drugs 2005;23:121-122.
25. Lansky EP, Jiang W, Mo H, Bravo L, Froom P, Yu W, Harris NM, Neeman I, Campbell MJ: Possible synergistic prostate cancer suppression by anatomically discrete pomeranate fractions. Invest New Drugs 2005;23:11-20.
26. Arao K, Yotsumoto H, Han SY, Nagao K, Yanagita T: The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells. Biosci Biotechnol Biochem 2004;68:2643-2645.
27. Li D, Sinclair A, Wilson A, Nakkote S, Kelly F, Abedin L, Mann N, Turner A: Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. Am J Clin Nutr 1999;69:872-882.
28. Burdge GC, Wright P, Jones AE, Wootton SA: A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr 2000;84:781-787.
29. Christie WW: A simple procedure for rapid transmethylation of glycerolipids and cholesteryl esters. J Lipid Res 1982;23: 1072-1075.
30. Christie WW: Mass spectrometry of fatty acids with methylene-interrupted ene-yne systems. Chem Phys Lipids 1998;94:35- 41.