Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity

Biochemical and Biophysical Research Communications

Volumn 386, Issue 2, 2009, Pages 351-355

  Su, Hua ^a   Gunter, Jennifer H ^a   de Vries, Melissa ^b   Connor, Tim ^b   Wanyonyi, Stephen ^b   Newell, Felicity S ^a   Segal, David ^b   Molero, Juan Carlos ^b   Reizes, Ofer ^c   Prins, Johannes B ^a   Hutley, Louise J ^a   Walder, Ken ^b,d   Whitehead, Jonathan P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Verva Pharmaceuticals Ltd   (Australia)

Author keywords

Adipocyte; Guanine nucleotides; IMPDH; Obesity

Indexed keywords

ADIPONECTIN; CHOLESTEROL; FAT DROPLET; GLUCOSE; GUANOSINE; GUANOSINE TRIPHOSPHATE; INOSINATE DEHYDROGENASE; INSULIN; LEPTIN; LIPID; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; CELL COUNT; CELL DIFFERENTIATION; CELL SIZE; CELL STRAIN 3T3; CONTROLLED STUDY; DIET; DRUG EFFECT; DRUG SPECIFICITY; ENZYME ACTIVITY; ENZYME INHIBITION; EPIDIDYMIS FAT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; LIPID COMPOSITION; LIVER; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; RETROPERITONEAL FAT; SKELETAL MUSCLE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; DIET; ENZYME INHIBITORS; GUANOSINE; IMP DEHYDROGENASE; MALE; MICE; MICE, INBRED C57BL; MYCOPHENOLIC ACID; OBESITY; WEIGHT LOSS;

MUS;

EID: 67649422585     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.040     Document Type: Article

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