메뉴 건너뛰기




Volumn 106, Issue 4, 2009, Pages 509-515

The effects of sildenafil and acetazolamide on breathing efficiency and ventilatory control during hypoxic exercise

Author keywords

Acetazolamide; Altitude; Breathing; Exercise; Sildenafil; Ventilation

Indexed keywords

ACETAZOLAMIDE; OXYGEN; PLACEBO; SILDENAFIL;

EID: 67649344538     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-009-1042-5     Document Type: Article
Times cited : (17)

References (35)
  • 1
    • 0037183551 scopus 로고    scopus 로고
    • Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: A double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction
    • doi: 10.1161/01.CIR.0000027149.83473.B6
    • Bocchi EA, Guimaraes G, Mocelin A et al (2002) Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: A double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 106:1097-1103. doi: 10.1161/01.CIR.0000027149.83473.B6
    • (2002) Circulation , vol.106 , pp. 1097-1103
    • Bocchi, E.A.1    Guimaraes, G.2    Mocelin, A.3
  • 2
    • 0019951046 scopus 로고
    • Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area
    • Capen RL, Wagner WW Jr (1982) Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area. J Appl Physiol 52:1575-1580
    • (1982) J Appl Physiol , vol.52 , pp. 1575-1580
    • Capen, R.L.1    Wagner Jr., W.W.2
  • 3
    • 0017625156 scopus 로고
    • Pulmonary adaptation to exercise: Effects of exercise type and duration, chronic hypoxia and physical training
    • doi: 10.1111/j.1749-6632.1977.tb38203.x
    • Dempsey JA, Gledhill N, Reddan WG et al (1977) Pulmonary adaptation to exercise: Effects of exercise type and duration, chronic hypoxia and physical training. Ann NY Acad Sci 301:243-261. doi: 10.1111/ j.1749-6632.1977.tb38203.x
    • (1977) Ann NY Acad Sci , vol.301 , pp. 243-261
    • Dempsey, J.A.1    Gledhill, N.2    Reddan, W.G.3
  • 4
    • 35348947437 scopus 로고    scopus 로고
    • Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes
    • doi: 10.1152/japplphysiol.00180.2007
    • Faoro V, Huez S, Giltaire S et al (2007a) Effects of acetazolamide on aerobic exercise capacity and pulmonary hemodynamics at high altitudes. J Appl Physiol 103:1161-1165. doi: 10.1152/japplphysiol.00180.2007
    • (2007) J Appl Physiol , vol.103 , pp. 1161-1165
    • Faoro, V.1    Huez, S.2    Giltaire, S.3
  • 5
    • 34347211800 scopus 로고    scopus 로고
    • Effects of sildenafil on exercise capacity in hypoxic normal subjects
    • doi: 10.1089/ham.2007.1058
    • Faoro V, Lamotte M, Deboeck G et al (2007b) Effects of sildenafil on exercise capacity in hypoxic normal subjects. High Alt Med Biol 8:155-163. doi: 10.1089/ham.2007.1058
    • (2007) High Alt Med Biol , vol.8 , pp. 155-163
    • Faoro, V.1    Lamotte, M.2    Deboeck, G.3
  • 6
    • 0031904847 scopus 로고    scopus 로고
    • Maximal and submaximal exercise performance at altitude
    • Fulco CS, Rock PB, Cymerman A (1998) Maximal and submaximal exercise performance at altitude. Aviat Space Environ Med 69:793-801
    • (1998) Aviat Space Environ Med , vol.69 , pp. 793-801
    • Fulco, C.S.1    Rock, P.B.2    Cymerman, A.3
  • 7
    • 0037369372 scopus 로고    scopus 로고
    • Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions
    • Garske LA, Brown MG, Morrison SC (2003) Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions. J Appl Physiol 94:991-996
    • (2003) J Appl Physiol , vol.94 , pp. 991-996
    • Garske, L.A.1    Brown, M.G.2    Morrison, S.C.3
  • 8
    • 3543120077 scopus 로고    scopus 로고
    • Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: A randomized, double-blind, placebo-controlled crossover trial
    • Ghofrani HA, Reichenberger F, Kohstall MG et al (2004) Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: A randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141:169-177
    • (2004) Ann Intern Med , vol.141 , pp. 169-177
    • Ghofrani, H.A.1    Reichenberger, F.2    Kohstall, M.G.3
  • 9
    • 43549114527 scopus 로고
    • Observations on the composition of alveolar air on Everest, 1933
    • Greene R (1934) Observations on the composition of alveolar air on Everest, 1933. J Physiol 82:481-485
    • (1934) J Physiol , vol.82 , pp. 481-485
    • Greene, R.1
  • 10
    • 10644252927 scopus 로고    scopus 로고
    • The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure
    • doi: 10.1016/j.jacc.2004.09.041
    • Guazzi M, Tumminello G, Di Marco F et al (2004) The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure. J Am Coll Cardiol 44:2339-2348. doi: 10.1016/j.jacc.2004.09.041
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2339-2348
    • Guazzi, M.1    Tumminello, G.2    Di Marco, F.3
  • 11
    • 0035849994 scopus 로고    scopus 로고
    • High-altitude illness
    • doi: 10.1056/NEJM200107123450206
    • Hackett PH, Roach RC (2001) High-altitude illness. N Engl J Med 345:107-114. doi: 10.1056/NEJM200107123450206
    • (2001) N Engl J Med , vol.345 , pp. 107-114
    • Hackett, P.H.1    Roach, R.C.2
  • 12
    • 0023126301 scopus 로고
    • Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide
    • Hackett PH, Roach RC, Harrison GL et al (1987) Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine versus acetazolamide. Am Rev Respir Dis 135:896-898
    • (1987) Am Rev Respir Dis , vol.135 , pp. 896-898
    • Hackett, P.H.1    Roach, R.C.2    Harrison, G.L.3
  • 13
    • 33744916246 scopus 로고    scopus 로고
    • Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia
    • doi: 10.1152/japplphysiol.00806.2005
    • Hsu AR, Barnholt KE, Grundmann NK et al (2006) Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia. J Appl Physiol 100:2031-2040. doi: 10.1152/ japplphysiol.00806.2005
    • (2006) J Appl Physiol , vol.100 , pp. 2031-2040
    • Hsu, A.R.1    Barnholt, K.E.2    Grundmann, N.K.3
  • 14
    • 33947182462 scopus 로고    scopus 로고
    • Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise
    • doi: 10.1113/jphysiol.2006.120949
    • Jonk AM, van den Berg IP, Olfert IM et al (2007) Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise. J Physiol 579:909-921. doi: 10.1113/jphysiol.2006.120949
    • (2007) J Physiol , vol.579 , pp. 909-921
    • Jonk, A.M.1    van den Berg, I.P.2    Olfert, I.M.3
  • 15
    • 36048969731 scopus 로고    scopus 로고
    • Right ventricular function with hypoxic exercise: Effects of sildenafil
    • doi: 10.1007/s00421-007-0560-2
    • Kjaergaard J, Snyder EM, Hassager C et al (2007) Right ventricular function with hypoxic exercise: Effects of sildenafil. Eur J Appl Physiol 102:87-95. doi: 10.1007/s00421-007-0560-2
    • (2007) Eur J Appl Physiol , vol.102 , pp. 87-95
    • Kjaergaard, J.1    Snyder, E.M.2    Hassager, C.3
  • 16
    • 0034691301 scopus 로고    scopus 로고
    • Impairment of ventilatory efficiency in heart failure: Prognostic impact
    • Kleber FX, Vietzke G, Wernecke KD et al (2000) Impairment of ventilatory efficiency in heart failure: Prognostic impact. Circulation 101:2803-2809
    • (2000) Circulation , vol.101 , pp. 2803-2809
    • Kleber, F.X.1    Vietzke, G.2    Wernecke, K.D.3
  • 17
    • 39149125446 scopus 로고    scopus 로고
    • Nitric oxide/cGMP protects endothelial cells from hypoxia-mediated leakiness
    • doi: 10.1016/j.ejcb.2007.10.001
    • Kolluru GK, Tamilarasan KP, Rajkumar AS et al (2008) Nitric oxide/cGMP protects endothelial cells from hypoxia-mediated leakiness. Eur J Cell Biol 87:147-161. doi: 10.1016/j.ejcb.2007.10.001
    • (2008) Eur J Cell Biol , vol.87 , pp. 147-161
    • Kolluru, G.K.1    Tamilarasan, K.P.2    Rajkumar, A.S.3
  • 18
    • 0000166557 scopus 로고
    • Lake Louise consensus on definition and quantification of altitude illness
    • In: Queen City Press, Burlington, Vermont
    • Lake Louise consensus on definition and quantification of altitude illMess. (1992) In: Hypoxia: mountain medicine. Queen City Press, Burlington, Vermont, pp 327-330
    • (1992) Hypoxia: Mountain Medicine , pp. 327-330
  • 19
    • 33846099444 scopus 로고    scopus 로고
    • Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    • doi: 10.1161/CIRCULATIONAHA.106.626226
    • Lewis GD, Lachmann J, Camuso J et al (2007) Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation 115:59-66. doi: 10.1161/CIRCULATIONAHA.106.626226
    • (2007) Circulation , vol.115 , pp. 59-66
    • Lewis, G.D.1    Lachmann, J.2    Camuso, J.3
  • 20
    • 0023902807 scopus 로고
    • Acute altitude exposure and altered acid-base states. I. Effects on the exercise ventilation and blood lactate responses
    • doi: 10.1007/BF00417990
    • McLellan T, Jacobs I, Lewis W (1988) Acute altitude exposure and altered acid-base states. I. Effects on the exercise ventilation and blood lactate responses. Eur J Appl Physiol Occup Physiol 57:435-444. doi: 10.1007/BF00417990
    • (1988) Eur J Appl Physiol Occup Physiol , vol.57 , pp. 435-444
    • McLellan, T.1    Jacobs, I.2    Lewis, W.3
  • 21
    • 0017160071 scopus 로고
    • Drive and timing components of ventilation
    • Milic-Emili J, Grunstein MM (1976) Drive and timing components of ventilation. Chest 70:131-133
    • (1976) Chest , vol.70 , pp. 131-133
    • Milic-Emili, J.1    Grunstein, M.M.2
  • 22
    • 67649326092 scopus 로고
    • Man's respiratory response during acclimatization to high altitude
    • Rahn H, Otis AB (1948) Man's respiratory response during acclimatization to high altitude. Fed Proc 7:96
    • (1948) Fed Proc , vol.7 , pp. 96
    • Rahn, H.1    Otis, A.B.2
  • 23
    • 35248898826 scopus 로고    scopus 로고
    • Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function
    • doi: 10.1016/j.resp.2007.07.005
    • Reichenberger F, Kohstall MG, Seeger T et al (2007) Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function. Respir Physiol Neurobiol 159:196-201. doi: 10.1016/ j.resp.2007.07.005
    • (2007) Respir Physiol Neurobiol , vol.159 , pp. 196-201
    • Reichenberger, F.1    Kohstall, M.G.2    Seeger, T.3
  • 24
    • 17344362498 scopus 로고    scopus 로고
    • Effects of sildenafil on the human response to acute hypoxia and exercise
    • doi: 10.1089/ham.2005.6.43
    • Ricart A, Maristany J, Fort N et al (2005) Effects of sildenafil on the human response to acute hypoxia and exercise. High Alt Med Biol 6:43-49. doi: 10.1089/ham.2005.6.43
    • (2005) High Alt Med Biol , vol.6 , pp. 43-49
    • Ricart, A.1    Maristany, J.2    Fort, N.3
  • 25
    • 12744261229 scopus 로고    scopus 로고
    • Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension
    • Richalet JP, Gratadour P, Robach P, et al (2005) Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 171:275-281
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 275-281
    • Richalet, J.P.1    Gratadour, P.2    Robach, P.3
  • 26
    • 0022598195 scopus 로고
    • Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs
    • Roberts AM, Bhattacharya J, Schultz HD et al (1986) Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs. Circ Res 58:512-522
    • (1986) Circ Res , vol.58 , pp. 512-522
    • Roberts, A.M.1    Bhattacharya, J.2    Schultz, H.D.3
  • 27
    • 0021013212 scopus 로고
    • Effect of acetazolamide on normoxic and hypoxic exercise in humans at sea level
    • Schoene RB, Bates PW, Larson EB et al (1983) Effect of acetazolamide on normoxic and hypoxic exercise in humans at sea level. J Appl Physiol 55:1772-1776
    • (1983) J Appl Physiol , vol.55 , pp. 1772-1776
    • Schoene, R.B.1    Bates, P.W.2    Larson, E.B.3
  • 28
    • 0037741441 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension
    • doi: 10.1161/01.CIR.0000074226.20466.B1
    • Sebkhi A, Strange JW, Phillips SC et al (2003) Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. Circulation 107:3230-3235. doi: 10.1161/01.CIR.0000074226.20466.B1
    • (2003) Circulation , vol.107 , pp. 3230-3235
    • Sebkhi, A.1    Strange, J.W.2    Phillips, S.C.3
  • 30
    • 43149118776 scopus 로고    scopus 로고
    • Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans
    • doi: 10.1007/s00421-008-0735-5
    • Snyder EM, Olson TP, Johnson BD et al (2008) Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans. Eur J Appl Physiol 103:421-430. doi: 10.1007/ s00421-008-0735-5
    • (2008) Eur J Appl Physiol , vol.103 , pp. 421-430
    • Snyder, E.M.1    Olson, T.P.2    Johnson, B.D.3
  • 31
    • 0036893514 scopus 로고    scopus 로고
    • Ventilatory efficiency during exercise in healthy subjects
    • doi: 10.1164/rccm.2202033
    • Sun XG, Hansen JE, Garatachea N et al (2002) Ventilatory efficiency during exercise in healthy subjects. Am J Respir Crit Care Med 166:1443-1448. doi: 10.1164/rccm.2202033
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1443-1448
    • Sun, X.G.1    Hansen, J.E.2    Garatachea, N.3
  • 32
    • 0032408134 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and ventilation: A complex interplay of stimulation and suppression
    • doi: 10.1183/09031936.98.12061242
    • Swenson ER (1998) Carbonic anhydrase inhibitors and ventilation: A complex interplay of stimulation and suppression. Eur Respir J 12:1242-1247. doi: 10.1183/09031936.98.12061242
    • (1998) Eur Respir J , vol.12 , pp. 1242-1247
    • Swenson, E.R.1
  • 33
    • 0014514550 scopus 로고
    • Ventilatory work during steady-state response to exercise
    • Thoden JS, Dempsey JA, Reddan WG et al (1969) Ventilatory work during steady-state response to exercise. Fed Proc 28:1316-1321
    • (1969) Fed Proc , vol.28 , pp. 1316-1321
    • Thoden, J.S.1    Dempsey, J.A.2    Reddan, W.G.3
  • 34
    • 0021143486 scopus 로고
    • Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation
    • Yock PG, Popp RL (1984) Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 70:657-662
    • (1984) Circulation , vol.70 , pp. 657-662
    • Yock, P.G.1    Popp, R.L.2
  • 35
    • 0035942990 scopus 로고    scopus 로고
    • Sildenafil inhibits hypoxia-induced pulmonary hypertension
    • doi: 10.1161/hc2901.093117
    • Zhao L, Mason NA, Morrell NW et al (2001) Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104:424-428. doi: 10.1161/hc2901.093117
    • (2001) Circulation , vol.104 , pp. 424-428
    • Zhao, L.1    Mason, N.A.2    Morrell, N.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.