Effect of sildenafil on hypoxia-induced changes in pulmonary circulation and right ventricular function

Respiratory Physiology and Neurobiology

Volumn 159, Issue 2, 2007, Pages 196-201

  Reichenberger, Frank ^a   Kohstall, Markus G ^a   Seeger, Timon ^a   Olschewski, Horst ^b   Grimminger, Friedrich ^a   Seeger, Werner ^a   Ghofrani, Hossein A ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b UNIVERSITY HOSPITAL GRAZ   (Austria)

Author keywords

Echocardiography; Hypoxia; Pulmonary circulation; Right ventricular function; Sildenafil

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; ALTITUDE ACCLIMATIZATION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOPPLER ECHOCARDIOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HEART RIGHT VENTRICLE FUNCTION; HUMAN; HYPOXIA; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG VASOCONSTRICTION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ALTITUDE; ANOXIA; DOUBLE-BLIND METHOD; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MOUNTAINEERING; PIPERAZINES; PULMONARY CIRCULATION; PURINES; SULFONES; VASODILATOR AGENTS; VENTRICULAR FUNCTION, RIGHT;

EID: 35248898826     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.07.005     Document Type: Article

References (31)

1. Allemann Y., Rotter M., Hutter D., Lipp E., Sartori C., Scherrer U., and Seiler C. Impact of acute hypoxic pulmonary hypertension on LV diastolic function in healthy mountaineers at high altitude. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H856-H862
2. Beard J.T., Newman J.H., Loyd J.E., and Byrd B.F. Doppler estimation of changes in pulmonary artery pressure during hypoxic breathing. J. Am. Soc. Echocardiogr. 4 (1991) 121-130
3. Boussuges A., Molenat F., Burnet H., Cauchy E., Gardette B., Sainty J.M., Jammes Y., and Richalet J.P. Operation Everest III (Comex '97): modifications of cardiac function secondary to altitude-induced hypoxia. An echocardiographic and Doppler study. Am. J. Respir. Crit. Care Med. 161 (2000) 264-270
4. Cogo A., Fischer R., and Schoene R. Respiratory diseases and high altitude. High Alt. Med. Biol. 5 (2004) 435-444
5. D'Alonzo G.E., Barst R.J., Ayres S.M., Bergofsky E.H., Brundage B.H., Detre K.M., Fishman A.P., Goldring R.M., Groves B.M., Kernis J.T., et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 115 (1991) 343-349
6. Dorrington K.L., Clar C., Young J.D., Jonas M., Tansley J.G., and Robbins P.A. Time course of the human pulmonary vascular response to 8 h of isocapnic hypoxia. Am. J. Physiol. 273 (1997) H1126-H1134
7. Dorrington K.L., and Talbot N.P. Human pulmonary vascular responses to hypoxia and hypercapnia. Eur. J. Physiol. 449 (2004) 1-15
8. Forfia P.R., Fisher M.R., Mathai S.C., Housten-Harris T., Hemnes A.R., Borlaug B.A., Chamera E., Corretti M.C., Champion H.C., Abraham T.P., Girgis R.E., and Hassoun P.M. Tricuspid annular displacement predicts survival in pulmonary hypertension. Am. J. Respir. Crit. Care Med. 174 (2006) 1034-1041
9. Galie N., Hinderliter A.L., Torbicki A., Fourme T., Simonneau G., Pulido T., Espinola-Zavaleta N., Rocchi G., Manes A., Frantz R., Kurzyna M., Nagueh S.F., Barst R., Channick R., Dujardin K., Kronenberg A., Leconte I., Rainisio M., and Rubin L. Effects of the oral endothelin-receptor antagonist bosentan on echo-cardiographic and Doppler measures in patients with pulmonary arterial hypertension. J. Am. Coll. Cardiol. 41 (2003) 1380-1386
10. Galie N., Seeger W., Naeije R., Simonneau G., and Rubin L.J. Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43 (2004) 81S-88S
11. Galie N., Ghofrani H.A., Torbicki A., Barst R.J., Rubin L.J., Badesch D., Fleming T., Parpia T., Burgess G., Branzi A., Grimminger F., Kurzyna M., and Simonneau G. Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. 353 (2005) 2148-2157
12. Ghofrani H.A., Wiedemann R., Rose F., Olschewski H., Schermuly R.T., Weissmann N., Seeger W., and Grimminger F. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann. Intern. Med. 136 (2002) 515-522
13. Ghofrani H.A., Wiedemann R., Rose F., Schermuly R.T., Olschewski H., Weissmann N., Gunther A., Walmrath D., Seeger W., and Grimminger F. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 360 (2002) 895-900
14. Ghofrani H.A., Schermuly R.T., Rose F., Wiedemann R., Kohstall M.G., Kreckel A., Olschewski H., Weissmann N., Enke B., Ghofrani S., Seeger W., and Grimminger F. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 167 (2003) 1139-1141
15. Ghofrani H.A., Reichenberger F., Kohstall M.G., Mrosek E.H., Seeger T., Olschewski H., Seeger W., and Grimminger F. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann. Intern. Med. 141 (2004) 169-177
16. Ghofrani H.A., Voswinckel R., Reichenberger F., Weissmann N., Schermuly R.T., Seeger W., and Grimminger F. Hypoxia- and non-hypoxia-related pulmonary hypertension-established and new therapies. Cardiovasc. Res. 72 (2006) 30-40
17. Grunig E., Mereles D., Hildebrandt W., Swenson E.R., Kubler W., Kuecherer H., and Bartsch P. Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. J. Am. Coll. Cardiol. 35 (2000) 980-987
18. Grunig E., Janssen B., Mereles D., Barth U., Borst M.M., Vogt I.R., Fischer C., Olschewski H., Kuecherer H.F., and Kubler W. Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene. Circulation 102 (2000) 1145-1150
19. Kaul S., Tei C., Hopkins J.M., and Shah P.M. Assessment of right ventricular function using two-dimensional echocardiography. Am. Heart J. 107 (1984) 526-531
20. Maggiorini M., and Leon-Velarde F. High-altitude pulmonary hypertension: a pathophysiological entity to different diseases. Eur. Respir. J. 22 (2003) 1019-1025
21. Maggiorini M., Brunner-La Rocca H.P., Peth S., Fischler M., Bohm T., Bernheim A., Kiencke S., Bloch K.E., Dehnert C., Naeije R., Lehmann T., Bartsch P., and Mairbaurl H. Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial. Ann. Intern. Med. 145 (2006) 497-506
22. Motley H.L., Cournand A., Werko L., Himmelstein A., and Dresdale D. The influence of short periods of acute anoxia upon pulmonary arterial pressures in man. Am. J. Physiol. 150 (1947) 315-320
23. Nagendran, J., Archer, S.L., Soliman, D., Gurtu, V., Moudgil, R., Haromy, A., St. Aubin, C., Webster, L., Rebeyka, I.M., Ross, D.B., Light, P.E., Dyck, J.R., Michelakis, E.D., 2007. Phosphodiesterase Type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation; Epub ahead of print.
24. Reichenberger F., Mensch O., Enke B., Voswinckel R., Ghofrani H.A., Olschewski H., and Seeger W. Noninvasive assessment of pulmonary circulation in scleroderma patients. Eur. Respir. J. 26 (2005) S49
25. Reichenberger F., Wehner L.E., Voswinckel R., Enke B., Mensch O., Olschewski H., Ghofrani H.A., and Seeger W. Pulmonary hypertension in hereditary haemorrhagic teleangiectasia. Am. J. Respir. Crit. Care. Med. 173 Suppl. (2006) A510
26. Richalet J.-P., Gratadour P., Robach P., Pham I., Déchaux M., Joncquiert-Latajet A., Mollard P., Brugniaux J., and Cornolo J. Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am. J. Respir. Crit. Care Med. 171 (2005) 275-281
27. Tei C., Dujardin K.S., Hodge D.O., Bailey K.R., McGoon M.D., Tajik A.J., and Seward S.B. Doppler echocardiographic index for assessment of global right ventricular function. J. Am. Soc. Echocardiogr. 9 (1996) 838-847
28. Vachiery J.L., McDonagh T., Moraine J.J., Berre J., Naeije R., Dargie H., and Peacock A.J. Doppler assessment of hypoxic pulmonary vasoconstriction and susceptibility to high altitude pulmonary oedema. Thorax 50 (1995) 22-27
29. Weitzenblum E., and Chaouat A. Pulmonary hypertension due to chronic hypoxic lung disease. In: Peacock A.J., and Rubin L.J. (Eds). Pulmonary Circulation. Diseases and Their Treatment. Chapter 15: Pulmonary Hypertension Associated with Disorders of the Respiratory System and/or Hypoxemia (2004), Arnold Publisher, London 374-386
30. Yeo T.C., Dujardin K.S., Tei C., Mahoney D.W., McGoon M.D., and Seward J.B. Value of a Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am. J. Cardiol. 81 (1998) 1157-1161
31. Zhao L., Mason N.A., Morrell N.W., Kojonazarov B., Sadykov A., Maripov A., Mirrakhimov M.M., Aldashev A., and Wilkins M.R. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104 (2001) 424-428