Performance of a modified supervised cluster algorithm for extracting reference region input functions from (R)-[11C]PKll195 brain PET studies

IEEE Nuclear Science Symposium Conference Record

Volumn , Issue , 2008, Pages 5400-5402

  Boellaard, Ronald ^a   Turkheimer, Federico E ^b   Hinz, Rainer ^c   Schuitemaker, Alie ^a   Scheltens, Phillip ^a   Van Berckel, B N M ^a   Lammertsma, Adriaan A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

(R) 11C PKll195; Alzheimer's disease; Positron emission tomography; Supervised cluster algorithm

Indexed keywords

(R)-[ 11C]PKLL195; ACCURACY AND PRECISION; ALZHEIMER'S DISEASE; ARTERIAL BLOOD SAMPLING; BLOOD VOLUMES; BRAIN TISSUE; CLUSTER ALGORITHMS; HEALTHY CONTROLS; INPUT FUNCTIONS; INPUT MODELS; KINETIC ANALYSIS; MICROGLIA; REFERENCE TISSUE MODEL; REGION OF INTEREST; SPECIFIC BINDING; SUPERVISED CLUSTER ALGORITHM; TARGET REGIONS; TIME-ACTIVITY CURVES;

ALGORITHMS; BLOOD; BRAIN; CLUSTER ANALYSIS; HEMODYNAMICS; PLASMAS; POSITRON ANNIHILATION SPECTROSCOPY; POSITRONS; TISSUE; TITRATION; TRACKING RADAR;

POSITRON EMISSION TOMOGRAPHY;

EID: 67649235111     PISSN: 10957863     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/NSSMIC.2008.4774453     Document Type: Conference Paper

References (6)

1. M. A. Kropholler, R. Boellaard, B. N. M. van Berckel, A. Schuitemaker, R. W. Kloet, M. J. Lubberink, C. Jonker, P. Scheltens, and A. A. Lammertsma, "Evaluation of reference regions for (R)-[(l 1)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment," J Cereb Blood Flow Metab, vol.27, no. 12, pp. 1965-1974, 2007. (Pubitemid 350129158)
2. J. Ashburner, J. Haslam, C. Taylor, V. J. Cunningham, and T. Jones, "A cluster analysis approach for the characterization of dynamic PET data," R. Myers, V. J. Cunningham, D. L. Bailey, and T. Jones, Eds. San Diego: Academic Press, 1996, ch. 59, pp. 301-306.
3. F. E. Turkheimer, P. Edison, N. Pavese. F. Roncaroli, A. N. Anderson, A. Hammers, A. Gerhard, R. Hinz, Y. F. Tai, and D. J. Brooks, "Reference and target region modeling of [11C]-(R)-PK11195 brain studies," J Nucl Med, vol.48, no. 1, pp. 158-167, 2007. (Pubitemid 47555390)
4. A. A. Lammertsma and S. P. Hume, "Simplified reference tissue model for PET receptor studies," Neurolmage, vol.4, pp. 153-158, 1996.
5. R. N. Gunn, P. A. Sargent, C. J. Bench, E. A. Rabiner, S. Osman, V. W. Pike, S. P. Hume, P. M. Grasby, and A. A. Lammertsma, "Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET" Neurolmage, vol.8, no. 4, pp. 426-440, 1998. (Pubitemid 28545940)
6. G. Tomasi, P. Edison, A. Bertoldo, F. Roncaroli, P. Singh, A. Gerhard, C. Cobelli, D. J. Brooks, and F. E. Turkheimer, "Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with alzheimer's disease," J Nucl Med, vol.49, no. 8, pp. 1249-1256,2008.